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ARATH:HMDH1

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) HMG1 (synonyms: HMGR1)
Protein Name(s) 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

AtHMGR1 HMG-CoA reductase 1

External Links
UniProt P14891
EMBL X15032
J04537
L19261
AY488113
AC012394
AC015450
CP002684
AF385690
BT000703
BT010468
PIR A32107
RefSeq NP_177775.2
UniGene At.22772
ProteinModelPortal P14891
SMR P14891
PaxDb P14891
PRIDE P14891
EnsemblPlants AT1G76490.1
GeneID 843982
KEGG ath:AT1G76490
TAIR AT1G76490
eggNOG COG1257
HOGENOM HOG000050844
InParanoid P14891
KO K00021
OMA GTRVETQ
PhylomeDB P14891
BioCyc ARA:AT1G76490-MONOMER
MetaCyc:AT1G76490-MONOMER
Reactome REACT_187634
REACT_258444
REACT_261238
UniPathway UPA00058
PRO PR:P14891
Proteomes UP000006548
ExpressionAtlas P14891
Genevestigator P14891
GO GO:0005783
GO:0005789
GO:0016021
GO:0004420
GO:0042282
GO:0050661
GO:0015936
GO:0019287
GO:0008299
GO:0055114
GO:0060964
GO:0016126
Gene3D 1.10.3270.10
3.30.70.420
3.90.770.10
InterPro IPR002202
IPR023074
IPR023076
IPR004554
IPR023282
IPR009023
IPR009029
PANTHER PTHR10572
Pfam PF00368
PRINTS PR00071
SUPFAM SSF55035
SSF56542
TIGRFAMs TIGR00533
PROSITE PS00066
PS00318
PS01192
PS50065

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042282

hydroxymethylglutaryl-CoA reductase activity

PMID:21478440[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042282

hydroxymethylglutaryl-CoA reductase activity

PMID:2649893[2]

ECO:0000250

sequence similarity evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0019287

isopentenyl diphosphate biosynthetic process, mevalonate pathway

PMID:21478440[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016126

sterol biosynthetic process

PMID:14871314[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|part_of

GO:0009536

plastid

PMID:15618432[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008299

isoprenoid biosynthetic process

PMID:8302869[5]

ECO:0000250

sequence similarity evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21478440[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:8302869[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

NOT|part_of

GO:0005777

peroxisome

PMID:15618432[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042282

hydroxymethylglutaryl-CoA reductase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000060346
RGD:2803
TAIR:locus:2011656
UniProtKB:P04035

F

Seeded From UniProt

complete

involved_in

GO:0016126

sterol biosynthetic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000060346
TAIR:locus:2011656
TAIR:locus:2827622

P

Seeded From UniProt

complete

involved_in

GO:0008299

isoprenoid biosynthetic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000060346
RGD:2803

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000060347
SGD:S000004442
SGD:S000004540
TAIR:locus:2011656

C

Seeded From UniProt

complete

part_of

GO:0005778

peroxisomal membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000060347
UniProtKB:P04035

C

Seeded From UniProt

complete

enables

GO:0004420

hydroxymethylglutaryl-CoA reductase (NADPH) activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96159
PANTHER:PTN000060346
PomBase:SPCC162.09c
SGD:S000004442
SGD:S000004540

F

Seeded From UniProt

complete

enables

GO:0004420

hydroxymethylglutaryl-CoA reductase (NADPH) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002202
InterPro:IPR004554
InterPro:IPR023074
InterPro:IPR023076
InterPro:IPR023282

F

Seeded From UniProt

complete

involved_in

GO:0008299

isoprenoid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004554

P

Seeded From UniProt

complete

involved_in

GO:0015936

coenzyme A metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002202
InterPro:IPR009029

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004554

C

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009029

F

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004554

F

Seeded From UniProt

complete

enables

GO:0050662

coenzyme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002202
InterPro:IPR009023
InterPro:IPR009029

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002202
InterPro:IPR004554
InterPro:IPR009029
InterPro:IPR023074
InterPro:IPR023076

P

Seeded From UniProt

complete

enables

GO:0004420

hydroxymethylglutaryl-CoA reductase (NADPH) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.34

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

involved_in

GO:0008299

isoprenoid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0414

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Leivar, P et al. (2011) Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A. Plant Cell 23 1494-511 PubMed GONUTS page
  2. ↑ Learned, RM & Fink, GR (1989) 3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Arabidopsis thaliana is structurally distinct from the yeast and animal enzymes. Proc. Natl. Acad. Sci. U.S.A. 86 2779-83 PubMed GONUTS page
  3. ↑ Suzuki, M et al. (2004) Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. Plant J. 37 750-61 PubMed GONUTS page
  4. ↑ 4.0 4.1 Leivar, P et al. (2005) Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Plant Physiol. 137 57-69 PubMed GONUTS page
  5. ↑ 5.0 5.1 Enjuto, M et al. (1994) Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme. Proc. Natl. Acad. Sci. U.S.A. 91 927-31 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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