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ARATH:DRM2

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) DRM2
Protein Name(s) DNA (cytosine-5)-methyltransferase DRM2

Protein DOMAINS REARRANGED METHYLASE 2

External Links
UniProt Q9M548
EMBL AF240695
AL163792
AL163792
CP002688
AK176138
AK220953
AK229197
PIR T48635
T48636
RefSeq NP_196966.2
UniGene At.5084
ProteinModelPortal Q9M548
SMR Q9M548
BioGrid 16592
DIP DIP-59279N
IntAct Q9M548
STRING 3702.AT5G14620.1-P
REBASE 4601
PaxDb Q9M548
PRIDE Q9M548
EnsemblPlants AT5G14620.1
GeneID 831315
KEGG ath:AT5G14620
TAIR AT5G14620
eggNOG NOG70699
HOGENOM HOG000030355
InParanoid Q9M548
OMA HSSLFYH
PhylomeDB Q9M548
BioCyc ARA:AT5G14620-MONOMER
Proteomes UP000006548
Genevestigator Q9M548
GO GO:0005654
GO:0005634
GO:0003886
GO:0003677
GO:0050832
GO:0006306
GO:0016458
GO:0051567
Gene3D 3.40.50.150
InterPro IPR029063
IPR030380
IPR009060
IPR015940
SMART SM00165
SUPFAM SSF46934
SSF53335
PROSITE PS51680
PS50030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009008

DNA-methyltransferase activity

PMID:21212233[1]

ECO:0000315

F

Figure 2

complete
CACAO 8324

part_of

GO:0005654

nucleoplasm

PMID:20410883[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0009008

DNA-methyltransferase activity

PMID:21212233[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016458

gene silencing

PMID:12121623[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051567

histone H3-K9 methylation

PMID:17239600[4]

ECO:0000316

genetic interaction evidence used in manual assertion

AGI_LocusCode:AT1G69770
AGI_LocusCode:AT5G15380

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:22242006[5]

ECO:0000316

genetic interaction evidence used in manual assertion

AGI_LocusCode:AT5G15380

P

Seeded From UniProt

complete

involved_in

GO:0006306

DNA methylation

PMID:16839879[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006306

DNA methylation

PMID:12151602[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10781108[8]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

involved_in

GO:0090116

C-5 methylation of cytosine

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003886

P

Seeded From UniProt

complete

involved_in

GO:0006306

DNA methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030380

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001525

F

Seeded From UniProt

complete

enables

GO:0003886

DNA (cytosine-5-)-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.37

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Naumann, U et al. (2011) Genetic evidence that DNA methyltransferase DRM2 has a direct catalytic role in RNA-directed DNA methylation in Arabidopsis thaliana. Genetics 187 977-9 PubMed GONUTS page
  2. Gao, Z et al. (2010) An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation. Nature 465 106-9 PubMed GONUTS page
  3. Cao, X & Jacobsen, SE (2002) Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. Curr. Biol. 12 1138-44 PubMed GONUTS page
  4. Johnson, LM et al. (2007) The SRA methyl-cytosine-binding domain links DNA and histone methylation. Curr. Biol. 17 379-84 PubMed GONUTS page
  5. López, A et al. (2011) The RNA silencing enzyme RNA polymerase v is required for plant immunity. PLoS Genet. 7 e1002434 PubMed GONUTS page
  6. Li, CF et al. (2006) An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana. Cell 126 93-106 PubMed GONUTS page
  7. Cao, X & Jacobsen, SE (2002) Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes. Proc. Natl. Acad. Sci. U.S.A. 99 Suppl 4 16491-8 PubMed GONUTS page
  8. Cao, X et al. (2000) Conserved plant genes with similarity to mammalian de novo DNA methyltransferases. Proc. Natl. Acad. Sci. U.S.A. 97 4979-84 PubMed GONUTS page