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PMID:21212233
| Citation |
Naumann, U, Daxinger, L, Kanno, T, Eun, C, Long, Q, Lorkovic, ZJ, Matzke, M and Matzke, AJ (2011) Genetic evidence that DNA methyltransferase DRM2 has a direct catalytic role in RNA-directed DNA methylation in Arabidopsis thaliana. Genetics 187:977-9 |
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| Abstract |
RNA-directed DNA methylation (RdDM) is a small RNA-mediated epigenetic modification in plants. We report here the identification of DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) in a forward screen for mutants defective in RdDM in Arabidopsis thaliana. The finding of a mutation in the presumptive active site argues in favor of direct catalytic activity for DRM2. |
| Links |
PubMed PMC3048785 Online version:10.1534/genetics.110.125401 |
| Keywords |
Amino Acid Sequence; Arabidopsis/genetics; Arabidopsis/metabolism; DNA Methylation/genetics; Methyltransferases/genetics; Methyltransferases/metabolism; Molecular Sequence Data; Point Mutation; RNA/genetics; RNA/metabolism; RNA, Small Interfering/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0009008: DNA-methyltransferase activity |
ECO:0000315: |
F |
Figure 2 |
complete | ||||
|
enables |
GO:0009008: DNA-methyltransferase activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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