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ARATH:2AAA

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) PP2AA1 (synonyms: EER1, RCN1, REGA)
Protein Name(s) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

AtA alpha PP2A, subunit A, alpha isoform PR-65 A Protein ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID 1 Protein enhancer of ethylene-response 1

External Links
UniProt Q38845
EMBL X82001
U21557
U27299
AC079281
CP002684
AY120757
BT000108
AK220793
AK222057
PIR B86385
S51807
S69215
RefSeq NP_173920.1
UniGene At.160
ProteinModelPortal Q38845
SMR Q38845
BioGrid 24372
IntAct Q38845
PaxDb Q38845
PRIDE Q38845
EnsemblPlants AT1G25490.1
GeneID 839135
KEGG ath:AT1G25490
TAIR AT1G25490
eggNOG NOG247268
HOGENOM HOG000078539
InParanoid Q38845
KO K03456
OMA TELRATY
PhylomeDB Q38845
Reactome REACT_187829
REACT_206508
REACT_208246
REACT_245715
REACT_248260
REACT_255447
REACT_260588
REACT_262782
Proteomes UP000006548
Genevestigator Q38845
GO GO:0005618
GO:0005634
GO:0005886
GO:0000159
GO:0008601
GO:0009738
GO:0009926
GO:0009734
GO:0009873
GO:0009789
GO:0050790
GO:0035304
GO:0010119
GO:0009723
Gene3D 1.25.10.10
InterPro IPR011989
IPR016024
IPR021133
SUPFAM SSF48371
PROSITE PS50077

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009737

response to abscisic acid stimulus

PMID:18650210[1]

ECO:0000315

P

Fig.1 ABA-induced stomatal closure was impaired in rcn1 mutant

complete

GO:0090333

regulation of stomatal closure

PMID:18650210[1]

ECO:0000315

P

Fig.1 ABA-induced stomatal closure was impaired in rcn1 mutant

complete

GO:0009738

abscisic acid mediated signaling pathway

PMID:18650210[1]

ECO:0000315

P

Fig.1 Responds to ABA stimulus and drives stomatal movement and ROS production

complete

GO:0009753

response to jasmonic acid stimulus

PMID:18650210[1]

ECO:0000315

P

Fig.1

complete

GO:0080010

regulation of oxygen and reactive oxygen species metabolic process

PMID:18650210[1]

ECO:0000315

P

Fig.1 Neither MeJA nor ABA promoted ROS production in rcn1 guard cells unlike wild-type guard cells.

complete

GO:0009867

jasmonic acid mediated signaling pathway

PMID:18650210[1]

ECO:0000315

P

Fig.2B RCN1 functions upstream of ROS production as a positive transducer of MeJA signaling in guard cells

complete

GO:0006970

response to osmotic stress

PMID:18162590[2]

ECO:0000316

UniProtKB:P31383


P

Fig.1D

complete

GO:0046620

regulation of organ growth

PMID:18162590[2]

ECO:0000315

P

Fig.2B,C complementation of the rcn1 hypocotyl elongation defect

hypocotyls = plant organ

complete

GO:2000067

regulation of root morphogenesis

PMID:18162590[2]

ECO:0000315

P

Fig.3

complete

GO:0016791

phosphatase activity

PMID:18162590[2]

ECO:0000315

F

Fig.4A-D chemical inhibition (cantharidin) of PP activity..disrupts normal root tip development

complete

GO:0048528

post-embryonic root development

PMID:18162590[2]

ECO:0000315

P

Fig.4A-D

complete

GO:0010628

positive regulation of gene expression

PMID:18162590[2]

ECO:0000315

P

Fig.4F-H cantharidin-treated seedling roots; Loss of phosphatase activity; reduced expression of AGL42-GFP (specific to QC)

complete

incorrect (CACAO)

GO:0009926

auxin polar transport

PMID:18162590[2]

ECO:0000315

P

Fig.4H-L Reductions in phosphatase activity (Cantharidin-treated seedlings) reduce auxin conc. around the initial cells

complete

GO:0005737

cytoplasm

PMID:18162590[2]

ECO:0000314

C

Fig.5D-F

complete

GO:0005634

nucleus

PMID:18162590[2]

ECO:0000314

C

Fig.5G-I

complete

GO:0016020

membrane

PMID:18162590[2]

ECO:0000314

C

Fig.5G-L

complete

GO:0006950

response to stress

PMID:18162590[2]

ECO:0000315

P

Fig.7A-D

complete

GO:0006979

response to oxidative stress

PMID:18162590[2]

ECO:0000315

P

Fig.7D Oxidative stress inhibited elongation

complete

GO:0090351

seedling development

PMID:14973165[3]

ECO:0000315

P

table 2

complete

GO:0048826

cotyledon morphogenesis

PMID:14973165[3]

ECO:0000315

P

table 2

complete

involved_in

GO:0035304

regulation of protein dephosphorylation

PMID:22781128[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010119

regulation of stomatal movement

PMID:12417706[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009926

auxin polar transport

PMID:11449059[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009789

positive regulation of abscisic acid-activated signaling pathway

PMID:12417706[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009723

response to ethylene

PMID:11161061[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:17644812[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18162590[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:16287169[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019888

protein phosphatase regulator activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000068596
TAIR:locus:2031165

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000068663
SGD:S000000014
UniProtKB:Q32PI5

C

Seeded From UniProt

complete

contributes_to

GO:0004722

protein serine/threonine phosphatase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1926334
PANTHER:PTN000068596
SGD:S000000014
UniProtKB:Q5ADN1
dictyBase:DDB_G0283601

F

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1926334
PANTHER:PTN000068663
SGD:S000000014
UniProtKB:P30153
WB:WBGene00003901
dictyBase:DDB_G0283601

C

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004722

P

Seeded From UniProt

complete

involved_in

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019888

P

Seeded From UniProt

complete

involved_in

GO:0009738

abscisic acid-activated signaling pathway

PMID:12417706[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000159

protein phosphatase type 2A complex

PMID:8641277[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0611

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0009873

ethylene-activated signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0936

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0009738

abscisic acid-activated signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0938

P

Seeded From UniProt

complete

involved_in

GO:0009734

auxin-activated signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0927

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Saito, N et al. (2008) Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid. Plant Cell Physiol. 49 1396-401 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 Blakeslee, JJ et al. (2008) Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem organization and stress response in roots. Plant Physiol. 146 539-53 PubMed GONUTS page
  3. 3.0 3.1 Zhou, HW et al. (2004) Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A. Plant Cell 16 709-22 PubMed GONUTS page
  4. Demarsy, E et al. (2012) Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor. EMBO J. 31 3457-67 PubMed GONUTS page
  5. 5.0 5.1 5.2 Kwak, JM et al. (2002) Disruption of a guard cell-expressed protein phosphatase 2A regulatory subunit, RCN1, confers abscisic acid insensitivity in Arabidopsis. Plant Cell 14 2849-61 PubMed GONUTS page
  6. Rashotte, AM et al. (2001) Genetic and chemical reductions in protein phosphatase activity alter auxin transport, gravity response, and lateral root growth. Plant Cell 13 1683-97 PubMed GONUTS page
  7. Larsen, PB & Chang, C (2001) The Arabidopsis eer1 mutant has enhanced ethylene responses in the hypocotyl and stem. Plant Physiol. 125 1061-73 PubMed GONUTS page
  8. Marmagne, A et al. (2007) A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Mol. Cell Proteomics 6 1980-96 PubMed GONUTS page
  9. Bayer, EM et al. (2006) Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Proteomics 6 301-11 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  11. Garbers, C et al. (1996) A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. EMBO J. 15 2115-24 PubMed GONUTS page