ARATH:2AAA

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	PP2AA1 (synonyms: EER1, RCN1, REGA)
Protein Name(s)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform AtA alpha PP2A, subunit A, alpha isoform PR-65 A Protein ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID 1 Protein enhancer of ethylene-response 1
External Links
UniProt	Q38845
EMBL	X82001 U21557 U27299 AC079281 CP002684 AY120757 BT000108 AK220793 AK222057
PIR	B86385 S51807 S69215
RefSeq	NP_173920.1
UniGene	At.160
ProteinModelPortal	Q38845
SMR	Q38845
BioGrid	24372
IntAct	Q38845
PaxDb	Q38845
PRIDE	Q38845
EnsemblPlants	AT1G25490.1
GeneID	839135
KEGG	ath:AT1G25490
TAIR	AT1G25490
eggNOG	NOG247268
HOGENOM	HOG000078539
InParanoid	Q38845
KO	K03456
OMA	TELRATY
PhylomeDB	Q38845
Reactome	REACT_187829 REACT_206508 REACT_208246 REACT_245715 REACT_248260 REACT_255447 REACT_260588 REACT_262782
Proteomes	UP000006548
Genevestigator	Q38845
GO	GO:0005618 GO:0005634 GO:0005886 GO:0000159 GO:0008601 GO:0009738 GO:0009926 GO:0009734 GO:0009873 GO:0009789 GO:0050790 GO:0035304 GO:0010119 GO:0009723
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR021133
SUPFAM	SSF48371
PROSITE	PS50077

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0009737	response to abscisic acid stimulus	PMID:18650210^[1]	ECO:0000315			P	Fig.1 ABA-induced stomatal closure was impaired in rcn1 mutant	complete
	GO:0090333	regulation of stomatal closure	PMID:18650210^[1]	ECO:0000315			P	Fig.1 ABA-induced stomatal closure was impaired in rcn1 mutant	complete
	GO:0009738	abscisic acid mediated signaling pathway	PMID:18650210^[1]	ECO:0000315			P	Fig.1 Responds to ABA stimulus and drives stomatal movement and ROS production	complete
	GO:0009753	response to jasmonic acid stimulus	PMID:18650210^[1]	ECO:0000315			P	Fig.1	complete
	GO:0080010	regulation of oxygen and reactive oxygen species metabolic process	PMID:18650210^[1]	ECO:0000315			P	Fig.1 Neither MeJA nor ABA promoted ROS production in rcn1 guard cells unlike wild-type guard cells.	complete
	GO:0009867	jasmonic acid mediated signaling pathway	PMID:18650210^[1]	ECO:0000315			P	Fig.2B RCN1 functions upstream of ROS production as a positive transducer of MeJA signaling in guard cells	complete
	GO:0006970	response to osmotic stress	PMID:18162590^[2]	ECO:0000316		UniProtKB:P31383	P	Fig.1D	complete
	GO:0046620	regulation of organ growth	PMID:18162590^[2]	ECO:0000315			P	Fig.2B,C complementation of the rcn1 hypocotyl elongation defect hypocotyls = plant organ	complete
	GO:2000067	regulation of root morphogenesis	PMID:18162590^[2]	ECO:0000315			P	Fig.3	complete
	GO:0016791	phosphatase activity	PMID:18162590^[2]	ECO:0000315			F	Fig.4A-D chemical inhibition (cantharidin) of PP activity..disrupts normal root tip development	complete
	GO:0048528	post-embryonic root development	PMID:18162590^[2]	ECO:0000315			P	Fig.4A-D	complete
	GO:0010628	positive regulation of gene expression	PMID:18162590^[2]	ECO:0000315			P	Fig.4F-H cantharidin-treated seedling roots; Loss of phosphatase activity; reduced expression of AGL42-GFP (specific to QC)	complete
incorrect (CACAO)	GO:0009926	auxin polar transport	PMID:18162590^[2]	ECO:0000315			P	Fig.4H-L Reductions in phosphatase activity (Cantharidin-treated seedlings) reduce auxin conc. around the initial cells	complete
	GO:0005737	cytoplasm	PMID:18162590^[2]	ECO:0000314			C	Fig.5D-F	complete
	GO:0005634	nucleus	PMID:18162590^[2]	ECO:0000314			C	Fig.5G-I	complete
	GO:0016020	membrane	PMID:18162590^[2]	ECO:0000314			C	Fig.5G-L	complete
	GO:0006950	response to stress	PMID:18162590^[2]	ECO:0000315			P	Fig.7A-D	complete
	GO:0006979	response to oxidative stress	PMID:18162590^[2]	ECO:0000315			P	Fig.7D Oxidative stress inhibited elongation	complete
	GO:0090351	seedling development	PMID:14973165^[3]	ECO:0000315			P	table 2	complete
	GO:0048826	cotyledon morphogenesis	PMID:14973165^[3]	ECO:0000315			P	table 2	complete
involved_in	GO:0035304	regulation of protein dephosphorylation	PMID:22781128^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010119	regulation of stomatal movement	PMID:12417706^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009926	auxin polar transport	PMID:11449059^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009789	positive regulation of abscisic acid-activated signaling pathway	PMID:12417706^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009723	response to ethylene	PMID:11161061^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17644812^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18162590^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005618	cell wall	PMID:16287169^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019888	protein phosphatase regulator activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000068596 TAIR:locus:2031165	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000068663 SGD:S000000014 UniProtKB:Q32PI5	C	Seeded From UniProt	complete
contributes_to	GO:0004722	protein serine/threonine phosphatase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926334 PANTHER:PTN000068596 SGD:S000000014 UniProtKB:Q5ADN1 dictyBase:DDB_G0283601	F	Seeded From UniProt	complete
part_of	GO:0000159	protein phosphatase type 2A complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926334 PANTHER:PTN000068663 SGD:S000000014 UniProtKB:P30153 WB:WBGene00003901 dictyBase:DDB_G0283601	C	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004722	P	Seeded From UniProt	complete
involved_in	GO:0043666	regulation of phosphoprotein phosphatase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019888	P	Seeded From UniProt	complete
involved_in	GO:0009738	abscisic acid-activated signaling pathway	PMID:12417706^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000159	protein phosphatase type 2A complex	PMID:8641277^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0611	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0009873	ethylene-activated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0936	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0009738	abscisic acid-activated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0938	P	Seeded From UniProt	complete
involved_in	GO:0009734	auxin-activated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0927	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Saito, N et al. (2008) Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid. Plant Cell Physiol. 49 1396-401 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Blakeslee, JJ et al. (2008) Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem organization and stress response in roots. Plant Physiol. 146 539-53 PubMed GONUTS page
↑ ^3.0 ^3.1 Zhou, HW et al. (2004) Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A. Plant Cell 16 709-22 PubMed GONUTS page
↑ Demarsy, E et al. (2012) Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor. EMBO J. 31 3457-67 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kwak, JM et al. (2002) Disruption of a guard cell-expressed protein phosphatase 2A regulatory subunit, RCN1, confers abscisic acid insensitivity in Arabidopsis. Plant Cell 14 2849-61 PubMed GONUTS page
↑ Rashotte, AM et al. (2001) Genetic and chemical reductions in protein phosphatase activity alter auxin transport, gravity response, and lateral root growth. Plant Cell 13 1683-97 PubMed GONUTS page
↑ Larsen, PB & Chang, C (2001) The Arabidopsis eer1 mutant has enhanced ethylene responses in the hypocotyl and stem. Plant Physiol. 125 1061-73 PubMed GONUTS page
↑ Marmagne, A et al. (2007) A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Mol. Cell Proteomics 6 1980-96 PubMed GONUTS page
↑ Bayer, EM et al. (2006) Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Proteomics 6 301-11 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Garbers, C et al. (1996) A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. EMBO J. 15 2115-24 PubMed GONUTS page

[PMID:18650210-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Saito, N et al. (2008) Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid. Plant Cell Physiol. 49 1396-401 PubMed GONUTS page

[PMID:18162590-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Blakeslee, JJ et al. (2008) Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem organization and stress response in roots. Plant Physiol. 146 539-53 PubMed GONUTS page

[PMID:14973165-3] 3.0 ^3.1 Zhou, HW et al. (2004) Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A. Plant Cell 16 709-22 PubMed GONUTS page

[PMID:22781128-4] Demarsy, E et al. (2012) Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor. EMBO J. 31 3457-67 PubMed GONUTS page

[PMID:12417706-5] 5.0 ^5.1 ^5.2 Kwak, JM et al. (2002) Disruption of a guard cell-expressed protein phosphatase 2A regulatory subunit, RCN1, confers abscisic acid insensitivity in Arabidopsis. Plant Cell 14 2849-61 PubMed GONUTS page

[PMID:11449059-6] Rashotte, AM et al. (2001) Genetic and chemical reductions in protein phosphatase activity alter auxin transport, gravity response, and lateral root growth. Plant Cell 13 1683-97 PubMed GONUTS page

[PMID:11161061-7] Larsen, PB & Chang, C (2001) The Arabidopsis eer1 mutant has enhanced ethylene responses in the hypocotyl and stem. Plant Physiol. 125 1061-73 PubMed GONUTS page

[PMID:17644812-8] Marmagne, A et al. (2007) A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Mol. Cell Proteomics 6 1980-96 PubMed GONUTS page

[PMID:16287169-9] Bayer, EM et al. (2006) Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Proteomics 6 301-11 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8641277-11] Garbers, C et al. (1996) A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. EMBO J. 15 2115-24 PubMed GONUTS page

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ARATH:2AAA

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