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AEDAE:Q534Q6

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Species (Taxon ID) Aedes aegypti (Yellowfever mosquito) (Culex aegypti). (7159)
Gene Name(s) REL1 (ECO:0000313 with EMBL:AAW67214.1) (synonyms: REL1A (ECO:0000313 with EMBL:EAT40588.1))
Protein Name(s) AAEL007696-PA (ECO:0000313 with EMBL:EAT40588.1)

Dorsal isoform 1-A (ECO:0000313 with EMBL:AAW67214.1)

External Links
UniProt Q534Q6
EMBL AY748242
CH477460
RefSeq XP_001652840.1
UniGene Aae.17343
SMR Q534Q6
EnsemblMetazoa AAEL007696-RA
GeneID 5569526
KEGG aag:AaeL_AAEL007696
VectorBase AAEL007696
HOGENOM HOG000047696
KO K09255
OMA NIVWEEY
OrthoDB EOG725DJG
PhylomeDB Q534Q6
Proteomes UP000008820
GO GO:0005634
GO:0003700
Gene3D 2.60.40.10
2.60.40.340
InterPro IPR011363
IPR013783
IPR014756
IPR002909
IPR000451
IPR008967
IPR011539
Pfam PF00554
PIRSF PIRSF001716
PRINTS PR00057
SMART SM00429
SUPFAM SSF49417
SSF81296
PROSITE PS01204
PS50254

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0002218

activation of innate immune response

PMID:15722339[1]

ECO:0000315

P

Figure 4A shows transfection of REL1A alone can induce expression of Cecropin A and Defensin A in Aag2 cells. Figure 4D shows RNAi knockdown of REL1 decreases fungal infection survival in mosquitoes.

complete
CACAO 10029

involved_in

GO:0002218

activation of innate immune response

PMID:15722339[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011539
InterPro:IPR037059

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011363
InterPro:IPR011539
InterPro:IPR037059

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR011363

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR011363

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000451
InterPro:IPR008967
InterPro:IPR011539
InterPro:IPR037059

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011363

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Shin, SW et al. (2005) REL1, a homologue of Drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito Aedes aegypti. J. Biol. Chem. 280 16499-507 PubMed GONUTS page