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Category:Insulin signaling

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Annotation of human insulin signaling associated proteins started in Feb 2009 as part of the cardiovascular GO annotation initiative, at UCL. For more information please contact r.lovering@ucl.ac.uk

Aspect ID Term HUMAN

INSR

HUMAN

SHC1

HUMAN

IRS1

HUMAN

INS

HUMAN

AKT1

HUMAN

P85A

HUMAN

SRBS1

Biological ProcessGO:0000060protein import into nucleus, translocation IMP
Biological ProcessGO:0000165MAPKKK cascade IDA IDA
Biological ProcessGO:0000187activation of MAPK activity IMP IDA
Biological ProcessGO:0001678cellular glucose homeostasis ISS
Biological ProcessGO:0001934positive regulation of protein phosphorylation IDA IDA
Biological ProcessGO:0001938positive regulation of endothelial cell proliferation IMP
Biological ProcessGO:0002092positive regulation of receptor internalization IDA
Biological ProcessGO:0002674negative regulation of acute inflammatory response IDA
Biological ProcessGO:0003007heart morphogenesis IMP
Biological ProcessGO:0005979regulation of glycogen biosynthetic process IMP
Biological ProcessGO:0006112energy reserve metabolic process TAS
Biological ProcessGO:0006355regulation of transcription, DNA-dependent IMP NAS
Biological ProcessGO:0006367transcription initiation from RNA polymerase II promoter TAS
Biological ProcessGO:0006464protein modification process TAS
Biological ProcessGO:0006468protein phosphorylation IDA
Biological ProcessGO:0006469negative regulation of protein kinase activity IMP  ISS
Biological ProcessGO:0006521regulation of amino acid metabolic process IMP
Biological ProcessGO:0006644phospholipid metabolic process TAS
Biological ProcessGO:0006661phosphatidylinositol biosynthetic process TAS
Biological ProcessGO:0006809nitric oxide biosynthetic process TAS
Biological ProcessGO:0006915apoptosis TAS
Biological ProcessGO:0006916anti-apoptosis TAS
Biological ProcessGO:0006924activated T cell apoptosis IMP
Biological ProcessGO:0006936muscle contraction TAS
Biological ProcessGO:0006953acute-phase response IDA
Biological ProcessGO:0006979response to oxidative stress ISS
Biological ProcessGO:0007160cell-matrix adhesion TAS
Biological ProcessGO:0007165signal transduction TAS TAS
Biological ProcessGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ISS
Biological ProcessGO:0007173epidermal growth factor receptor signaling pathway TAS TAS TAS TAS
Biological ProcessGO:0007176regulation of epidermal growth factor recep... TAS
Biological ProcessGO:0007186G-protein coupled receptor protein signalin... IDA IDA TAS
Biological ProcessGO:0007265Ras protein signal transduction EXP  TAS
Biological ProcessGO:0007267cell-cell signaling IC
Biological ProcessGO:0007596blood coagulation TAS TAS TAS
Biological ProcessGO:0008219cell death NAS
Biological ProcessGO:0008283cell proliferation TAS
Biological ProcessGO:0008284positive regulation of cell proliferation IC  IDA NAS  TAS NAS IDA
Biological ProcessGO:0008286insulin receptor signaling pathway IDA  TAS IBA  ISS  TAS IDA  IMP  IPI  TAS IDA  TAS IMP IBA  IPI  TAS ISS
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathway TAS TAS TAS TAS TAS TAS
Biological ProcessGO:0008629induction of apoptosis by intracellular signals TAS
Biological ProcessGO:0008633activation of pro-apoptotic gene products EXP  TAS
Biological ProcessGO:0009408response to heat TAS
Biological ProcessGO:0009967positive regulation of signal transduction IC  ISS
Biological ProcessGO:0010467gene expression TAS
Biological ProcessGO:0010507negative regulation of autophagy IMP
Biological ProcessGO:0010748negative regulation of plasma membrane long-chain fatty acid transport IMP
Biological ProcessGO:0010907positive regulation of glucose metabolic process IMP IMP
Biological ProcessGO:0010951negative regulation of endopeptidase activity IMP
Biological ProcessGO:0010975regulation of neuron projection development ISS
Biological ProcessGO:0012501programmed cell death TAS
Biological ProcessGO:0014065phosphoinositide 3-kinase cascade IDA IDA IDA
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase cascade IDA
Biological ProcessGO:0015758glucose transport IDA ISS
Biological ProcessGO:0016070RNA metabolic process TAS
Biological ProcessGO:0016071mRNA metabolic process TAS
Biological ProcessGO:0016310phosphorylation IDA
Biological ProcessGO:0018105peptidyl-serine phosphorylation IDA
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylation IDA TAS
Biological ProcessGO:0019087transformation of host cell by virus IMP
Biological ProcessGO:0022898regulation of transmembrane transporter act... IDA
Biological ProcessGO:0030154cell differentiation TAS
Biological ProcessGO:0030168platelet activation TAS TAS TAS
Biological ProcessGO:0030307positive regulation of cell growth NAS IDA
Biological ProcessGO:0030334regulation of cell migration IMP  TAS
Biological ProcessGO:0030335positive regulation of cell migration IMP ISS
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein response TAS
Biological ProcessGO:0031018endocrine pancreas development TAS TAS
Biological ProcessGO:0031295T cell costimulation TAS TAS
Biological ProcessGO:0031659G1/S-specific positive regulation of cyclin... IDA
Biological ProcessGO:0031954positive regulation of protein autophosphorylation ISS
Biological ProcessGO:0031999negative regulation of fatty acid beta-oxidation IMP
Biological ProcessGO:0032000positive regulation of fatty acid beta-oxidation IMP
Biological ProcessGO:0032147activation of protein kinase activity IMP
Biological ProcessGO:0032148activation of protein kinase B activity IDA IDA
Biological ProcessGO:0032270positive regulation of cellular protein met... IMP ISS
Biological ProcessGO:0032460negative regulation of protein oligomerization IDA
Biological ProcessGO:0032583regulation of gene-specific transcription IMP NAS
Biological ProcessGO:0032868response to insulin stimulus IDA
Biological ProcessGO:0032869cellular response to insulin stimulus IDA IMP IMP  ISS ISS ISS
Biological ProcessGO:0032880regulation of protein localization IDA
Biological ProcessGO:0033120positive regulation of RNA splicing IMP
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylation IDA
Biological ProcessGO:0033861negative regulation of NAD(P)H oxidase acti... IDA
Biological ProcessGO:0034405response to fluid shear stress IMP
Biological ProcessGO:0034976response to endoplasmic reticulum stress IDA  ISS
Biological ProcessGO:0035556intracellular signal transduction IDA
Biological ProcessGO:0036498IRE1-mediated unfolded protein response TAS
Biological ProcessGO:0038095Fc-epsilon receptor signaling pathway TAS TAS TAS TAS
Biological ProcessGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Biological ProcessGO:0042060wound healing IDA
Biological ProcessGO:0042177negative regulation of protein catabolic pr... IDA
Biological ProcessGO:0042593glucose homeostasis IMP TAS IMP
Biological ProcessGO:0042993positive regulation of transcription factor import into nucleus IDA  ISS
Biological ProcessGO:0043066negative regulation of apoptosis NAS IDA  NAS IMP
Biological ProcessGO:0043149stress fiber formation ISS
Biological ProcessGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP  ISS
Biological ProcessGO:0043410positive regulation of MAPKKK cascade IDA  IMP IDA
Biological ProcessGO:0043434response to peptide hormone stimulus ISS
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migration IDA
Biological ProcessGO:0043551regulation of phosphatidylinositol 3-kinase activity IBA  ISS
Biological ProcessGO:0043552positive regulation of phosphatidylinositol 3-kinase activity ISS
Biological ProcessGO:0044267cellular protein metabolic process TAS TAS
Biological ProcessGO:0044281small molecule metabolic process TAS TAS TAS
Biological ProcessGO:0045087innate immune response TAS TAS TAS TAS
Biological ProcessGO:0045429positive regulation of nitric oxide biosynt... IMP NAS IMP
Biological ProcessGO:0045597positive regulation of cell differentiation NAS
Biological ProcessGO:0045600positive regulation of fat cell differentiation IMP
Biological ProcessGO:0045721negative regulation of gluconeogenesis NAS
Biological ProcessGO:0045725positive regulation of glycogen biosynthetic process IDA IMP  NAS IDA IMP  NAS ISS
Biological ProcessGO:0045740positive regulation of DNA replication IMP ISS IDA
Biological ProcessGO:0045818negative regulation of glycogen catabolic p... IMP
Biological ProcessGO:0045821positive regulation of glycolysis IMP IDA  IMP
Biological ProcessGO:0045840positive regulation of mitosis IMP NAS IDA
Biological ProcessGO:0045861negative regulation of proteolysis IMP IMP
Biological ProcessGO:0045908negative regulation of vasodilation NAS
Biological ProcessGO:0045909positive regulation of vasodilation NAS
Biological ProcessGO:0045922negative regulation of fatty acid metabolic... IMP
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoter IMP  ISS
Biological ProcessGO:0045995regulation of embryonic development IMP
Biological ProcessGO:0046209nitric oxide metabolic process TAS
Biological ProcessGO:0046326positive regulation of glucose import IDA  NAS IMP IDA IMP ISS ISS
Biological ProcessGO:0046627negative regulation of insulin receptor signaling pathway ISS
Biological ProcessGO:0046628positive regulation of insulin receptor signaling pathway ISS IDA
Biological ProcessGO:0046631alpha-beta T cell activation IDA
Biological ProcessGO:0046676negative regulation of insulin secretion IDA
Biological ProcessGO:0046777protein amino acid autophosphorylation IDA  IMP TAS
Biological ProcessGO:0046854phosphoinositide phosphorylation IBA  ISS
Biological ProcessGO:0046889positive regulation of lipid biosynthetic process NAS IMP ISS
Biological ProcessGO:0048009insulin-like growth factor receptor signali... IPI IMP IDA  IPI
Biological ProcessGO:0048010vascular endothelial growth factor receptor signaling pathway TAS TAS
Biological ProcessGO:0048011nerve growth factor receptor signaling pathway TAS TAS TAS TAS
Biological ProcessGO:0048015phosphatidylinositol-mediated signaling TAS TAS TAS
Biological ProcessGO:0048041focal adhesion formation ISS
Biological ProcessGO:0048639positive regulation of developmental growth IMP
Biological ProcessGO:0050708regulation of protein secretion IDA
Biological ProcessGO:0050709negative regulation of protein secretion IDA
Biological ProcessGO:0050715positive regulation of cytokine secretion IDA
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylation IDA
Biological ProcessGO:0050796regulation of insulin secretion TAS
Biological ProcessGO:0050821protein stabilization IDA
Biological ProcessGO:0050852T cell receptor signaling pathway TAS
Biological ProcessGO:0050900leukocyte migration TAS TAS
Biological ProcessGO:0050995negative regulation of lipid catabolic process IMP  NAS
Biological ProcessGO:0050999regulation of nitric-oxide synthase activity TAS
Biological ProcessGO:0051000positive regulation of nitric-oxide synthas... NAS IMP
Biological ProcessGO:0051091positive regulation of sequence-specific DNA binding transcription factor activity IDA
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activity IDA
Biological ProcessGO:0051290protein heterotetramerization IDA
Biological ProcessGO:0051897positive regulation of protein kinase B signaling cascade IMP IDA
Biological ProcessGO:0055089fatty acid homeostasis IMP
Biological ProcessGO:0060266negative regulation of respiratory burst du... IDA
Biological ProcessGO:0060267positive regulation of respiratory burst IDA IDA  NAS
Biological ProcessGO:0060396growth hormone receptor signaling pathway IDA
Biological ProcessGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway TAS
Biological ProcessGO:0060416response to growth hormone ISS
Biological ProcessGO:0060644mammary gland epithelial cell differentiation TAS
Biological ProcessGO:0061024membrane organization TAS
Biological ProcessGO:0070141response to UV-A IDA
Biological ProcessGO:0090004positive regulation of establishment of protein localization in plasma membrane IMP ISS ISS
Biological ProcessGO:0090201negative regulation of release of cytochrome c from mitochondria ISS
Biological ProcessGO:0090277positive regulation of peptide hormone secretion TAS
Biological ProcessGO:0090336positive regulation of brown fat cell differentiation TAS
Biological ProcessGO:0097017renal protein absorption IDA
Biological ProcessGO:0097193intrinsic apoptotic signaling pathway TAS
Biological ProcessGO:1900103positive regulation of endoplasmic reticulum unfolded protein response IMP
Biological ProcessGO:1900182positive regulation of protein localization to nucleus IDA
Biological ProcessGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Biological ProcessGO:1901143insulin catabolic process IDA
Biological ProcessGO:1901215negative regulation of neuron death NAS
Biological ProcessGO:1901976regulation of cell cycle checkpoint TAS
Biological ProcessGO:1902176negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway NAS NAS
Biological ProcessGO:1990418response to insulin-like growth factor stimulus ISS
Biological ProcessGO:2000252negative regulation of feeding behavior IDA
Biological ProcessGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
Biological ProcessGO:2001275positive regulation of glucose import in response to insulin stimulus IDA ISS
Cellular ComponentGO:0001725stress fiber ISS
Cellular ComponentGO:0005576extracellular region IC  TAS
Cellular ComponentGO:0005615extracellular space IDA
Cellular ComponentGO:0005634nucleus ISS IDA  TAS ISS IDA
Cellular ComponentGO:0005654nucleoplasm EXP  IDA  TAS IDA
Cellular ComponentGO:0005730nucleolusNOT IDA
Cellular ComponentGO:0005737cytoplasm ISS  TAS IDA  ISS  TAS IDA IDA
Cellular ComponentGO:0005788endoplasmic reticulum lumen TAS
Cellular ComponentGO:0005792microsome IDA ISS
Cellular ComponentGO:0005796Golgi lumen TAS
Cellular ComponentGO:0005813centrosome IDA IDA
Cellular ComponentGO:0005829cytosol TAS IBA  TAS EXP  IDA  TAS TAS ISS  TAS
Cellular ComponentGO:0005886plasma membrane IC  TAS IDA  TAS IBA  TAS IDA  TAS TAS IDA
Cellular ComponentGO:0005887integral to plasma membrane IDA
Cellular ComponentGO:0005899insulin receptor complex IMP ISScolocalizes_with IDA
Cellular ComponentGO:0005913cell-cell adherens junction ISS  TAS
Cellular ComponentGO:0005915zonula adherens TAS
Cellular ComponentGO:0005924cell-substrate adherens junction ISS
Cellular ComponentGO:0005925focal adhesion IDA
Cellular ComponentGO:0005942phosphatidylinositol 3-kinase complex IBA  ISS
Cellular ComponentGO:00059431-phosphatidylinositol-4-phosphate 3-kinase... ISS
Cellular ComponentGO:0010008endosome membrane TAS
Cellular ComponentGO:0015630microtubule cytoskeleton IDA
Cellular ComponentGO:0016020membrane IDA IDA
Cellular ComponentGO:0030141stored secretory granule TAS
Cellular ComponentGO:0031904endosome lumen TAS
Cellular ComponentGO:0034774secretory granule lumen TAS
Cellular ComponentGO:0043231intracellular membrane-bounded organelle ISS
Cellular ComponentGO:0043235receptor complex IDA
Cellular ComponentGO:0045121membrane raft ISS
Cellular ComponentGO:0070062extracellular exosome IDA
Cellular ComponentGO:0070435Shc-EGFR complex ISS
Molecular FunctionGO:0002020protease binding IPI
Molecular FunctionGO:0003779actin binding TAS
Molecular FunctionGO:0003985acetyl-CoA C-acetyltransferase activity IDA
Molecular FunctionGO:0004672protein kinase activity TAS
Molecular FunctionGO:0004674protein serine/threonine kinase activity IDA  TAS
Molecular FunctionGO:0004712protein serine/threonine/tyrosine kinase activity IDA
Molecular FunctionGO:0004713protein tyrosine kinase activity IDA  IMP TAS
Molecular FunctionGO:0004716receptor signaling protein tyrosine kinase ... IDA
Molecular FunctionGO:0004871signal transducer activity TAS
Molecular FunctionGO:0005009insulin receptor activity IDA
Molecular FunctionGO:0005068transmembrane receptor protein tyrosine kin... TAS ISS  TAS ISS
Molecular FunctionGO:0005069transmembrane receptor protein tyrosine kin... TAS
Molecular FunctionGO:0005070SH3/SH2 adaptor activity IC  ISS
Molecular FunctionGO:0005080protein kinase C binding ISS
Molecular FunctionGO:0005154epidermal growth factor receptor binding ISS
Molecular FunctionGO:0005158insulin receptor binding IPI IPI IDA  IPI IPI IDA
Molecular FunctionGO:0005159insulin-like growth factor receptor binding IDA IPI IPI IPI IPI
Molecular FunctionGO:0005168neurotrophin TRKA receptor binding IPI IPI
Molecular FunctionGO:0005179hormone activity IC  IMP  NAS
Molecular FunctionGO:0005515protein binding IPI IPI IPI IPI IPI IPI IPI
Molecular FunctionGO:0005520insulin-like growth factor binding IPI
Molecular FunctionGO:0005524ATP binding IDA IC  IDA
Molecular FunctionGO:0005525GTP binding IDA
Molecular FunctionGO:0005543phospholipid binding TAS
Molecular FunctionGO:0005545phosphatidylinositol binding NAS
Molecular FunctionGO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA
Molecular FunctionGO:0008092cytoskeletal protein binding TAS
Molecular FunctionGO:0008134transcription factor binding IPI
Molecular FunctionGO:0016301kinase activity IDA
Molecular FunctionGO:0019899enzyme binding ISS
Molecular FunctionGO:0019901protein kinase binding IBA
Molecular FunctionGO:0019903protein phosphatase binding IPI
Molecular FunctionGO:0019904protein domain specific binding IPI
Molecular FunctionGO:0030235nitric-oxide synthase regulator activity IMP
Molecular FunctionGO:0031994insulin-like growth factor I binding IPI
Molecular FunctionGO:0031995insulin-like growth factor II binding IPI
Molecular FunctionGO:0035014phosphoinositide 3-kinase regulator activity ISS
Molecular FunctionGO:0042169SH2 domain binding IPI ISS
Molecular FunctionGO:0042301phosphate binding IDA
Molecular FunctionGO:0042802identical protein binding IPI IPI
Molecular FunctionGO:0043125ErbB-3 class receptor binding IDA
Molecular FunctionGO:0043325phosphatidylinositol-3,4-bisphosphate binding IDA
Molecular FunctionGO:0043548phosphoinositide 3-kinase binding IPI IPI  ISS ISS
Molecular FunctionGO:0043559insulin binding IDA  IPI IDA
Molecular FunctionGO:0043560insulin receptor substrate binding IPI ISS
Molecular FunctionGO:0046875ephrin receptor binding IPI
Molecular FunctionGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS TAS
Molecular FunctionGO:00469351-phosphatidylinositol-3-kinase regulator activity IBA
Molecular FunctionGO:0051425PTB domain binding IPI
Molecular FunctionGO:007188914-3-3 protein binding IPI
Cellular ComponentGO:0005901caveola IDA IDA

Cellular Component graph



RefGenome graph at MGI.


Molecular Function graph



RefGenome graph at MGI.


Biological Process graph



RefGenome graph at MGI.



Pages in category "Insulin signaling"

The following 7 pages are in this category, out of 7 total.