HUMAN:SHC1

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Species (Taxon ID)	Homo sapiens (9606) - Human
Gene Name(s)	SHC1 (synonyms: SHC, SHCA)
Protein Name(s)	SHC-transforming protein 1
Protein Identifiers from UniProt and NCBI
UniProt Accession	P29353, O15290, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1,
UniProt ID	SHC1_HUMAN,
RefSeq	NP_001123513, NP_003020, NP_892113,
GI Number	119573553, 119573554, 119573555, 15559595, 157831972, 157879339, 157879584, 158257718, 159162898, 164691101, 17380299, 1834515, 1899055, 194239662, 194239664, 194239668, 21706900, 32261324, 36454, 55960110, 55960111, 55960112, 55960113, 55960116,
Genpept Accession	AAB49972, AAH14158, AAH33925, BAF84832, BAF98733, CAA48251, CAA70977, CAI13248, CAI13249, CAI13250, CAI13251, CAI13254, EAW53168, EAW53169, EAW53170,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol				C	Source: Reactome
	GO:0005739	mitochondrion		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0005886	plasma membrane		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005158	insulin receptor binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0005159	insulin-like growth factor receptor binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0005543	phospholipid binding		TAS: Traceable Author Statement		F	Source: UniProtKB
	GO:0005068	transmembrane receptor protein tyrosine kin...		TAS: Traceable Author Statement		F	Source: UniProtKB
	GO:0000187	activation of MAPK activity		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0008284	positive regulation of cell proliferation		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0045840	positive regulation of mitosis		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0007265	Ras protein signal transduction		EXP: Inferred from Experiment		P	Source: Reactome	required field missing
	GO:0001558	regulation of cell growth		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0007176	regulation of epidermal growth factor recep...		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0000165	MAPKKK cascade	PMID:14676841^[1]	IDA: Inferred from Direct Assay		P
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0000187	activation of MAPK activity	PMID:14676841^[1]	IDA: Inferred from Direct Assay		P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0001784	phosphotyrosine binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	F
	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	PMID:14676841^[1]	TAS: Traceable Author Statement		F
	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	PMID:1623525^[2]	TAS: Traceable Author Statement		F
	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	F
	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5M824	F
	GO:0005158	insulin receptor binding	PMID:7537849^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P06213	F
	GO:0005158	insulin receptor binding	PMID:7559478^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P06213	F
	GO:0005159	insulin-like growth factor receptor binding	PMID:7541045^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P08069	F
	GO:0005515	protein binding	PMID:11877420^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P05067	F
	GO:0005515	protein binding	PMID:19172738^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQC2	F
	GO:0005515	protein binding	PMID:20935677^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P03372-4	F
	GO:0005515	protein binding	PMID:21278788^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P00533	F
	GO:0005515	protein binding	PMID:7541045^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P08069	F
	GO:0005515	protein binding	PMID:8491186^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P62993	F
	GO:0005543	phospholipid binding	PMID:14676841^[1]	TAS: Traceable Author Statement		F
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005739	mitochondrion	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0173	C
	GO:0005759	mitochondrial matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0170	C
	GO:0005829	cytosol	Reactome:REACT_106	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12003	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12017	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12402	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12409	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12514	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12580	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12592	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_1411	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_1420	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_176	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_18273	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_2010	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_2015	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21333	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21344	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21357	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_22439	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23782	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23801	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23821	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23828	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23856	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23857	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23874	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23911	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23928	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23971	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_24024	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27150	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_27317	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_596	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	C
	GO:0005886	plasma membrane	PMID:14676841^[1]	IDA: Inferred from Direct Assay		C
	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:1623525^[2]	TAS: Traceable Author Statement		P
	GO:0007173	epidermal growth factor receptor signaling pathway	Reactome:REACT_9417	TAS: Traceable Author Statement		P
	GO:0007176	regulation of epidermal growth factor-activated receptor activity	PMID:1623525^[2]	TAS: Traceable Author Statement		P
	GO:0007265	Ras protein signal transduction	Reactome:REACT_12033	TAS: Traceable Author Statement		P
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0007568	aging	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008284	positive regulation of cell proliferation	PMID:14676841^[1]	NAS: Non-traceable Author Statement		P
	GO:0008284	positive regulation of cell proliferation	PMID:1623525^[2]	TAS: Traceable Author Statement		P
	GO:0008286	insulin receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0008286	insulin receptor signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5M824	P
	GO:0008286	insulin receptor signaling pathway	Reactome:REACT_498	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9470	TAS: Traceable Author Statement		P
	GO:0009636	response to toxin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0010008	endosome membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	C
	GO:0014070	response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0016337	cell-cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0030036	actin cytoskeleton organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0030182	neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0031100	organ regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0031175	neuron projection development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091940	P
	GO:0032403	protein complex binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	F
	GO:0032868	response to insulin stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0035094	response to nicotine	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0035556	intracellular signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006019	P
	GO:0040008	regulation of growth	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0341	P
	GO:0042542	response to hydrogen peroxide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0045740	positive regulation of DNA replication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0045740	positive regulation of DNA replication	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5M824	P
	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0050900	leukocyte migration	Reactome:REACT_12051	TAS: Traceable Author Statement		P
	GO:0051219	phosphoprotein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	F
	GO:0051384	response to glucocorticoid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	P
	GO:0070435	Shc-EGFR complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000028038	C
	GO:0070435	Shc-EGFR complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5M824	C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Carloni V et al. (2004) Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene 23: 1566-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Pelicci G et al. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93-104 PubMed GONUTS page
↑ Gustafson TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell Biol 15: 2500-8 PubMed GONUTS page
↑ He W et al. (1995) Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. J Biol Chem 270: 23258-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Craparo A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem 270: 15639-43 PubMed GONUTS page
↑ Tarr PE et al. (2002) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J Biol Chem 277: 16798-804 PubMed GONUTS page
↑ Brummer T et al. (2008) Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J 27: 2305-16 PubMed GONUTS page
↑ Zhang XT et al. (2011) A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells. Oncogene 30: 770-80 PubMed GONUTS page
↑ Jung J et al. (2011) Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src. Oncogene 30: 2264-74 PubMed GONUTS page
↑ Skolnik EY et al. (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 12: 1929-36 PubMed GONUTS page

[PMID:14676841-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Carloni V et al. (2004) Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. Oncogene 23: 1566-74 PubMed GONUTS page

[PMID:1623525-1] 2.0 ^2.1 ^2.2 ^2.3 Pelicci G et al. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93-104 PubMed GONUTS page

[PMID:7537849-2] Gustafson TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell Biol 15: 2500-8 PubMed GONUTS page

[PMID:7559478-3] He W et al. (1995) Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. J Biol Chem 270: 23258-62 PubMed GONUTS page

[PMID:7541045-4] 5.0 ^5.1 Craparo A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem 270: 15639-43 PubMed GONUTS page

[PMID:11877420-5] Tarr PE et al. (2002) Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J Biol Chem 277: 16798-804 PubMed GONUTS page

[PMID:19172738-6] Brummer T et al. (2008) Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J 27: 2305-16 PubMed GONUTS page

[PMID:20935677-7] Zhang XT et al. (2011) A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells. Oncogene 30: 770-80 PubMed GONUTS page

[PMID:21278788-8] Jung J et al. (2011) Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src. Oncogene 30: 2264-74 PubMed GONUTS page

[PMID:8491186-9] Skolnik EY et al. (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 12: 1929-36 PubMed GONUTS page

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HUMAN:SHC1

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