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HUMAN:SRBS1

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) SORBS1 ( synonyms: KIAA0894, KIAA1296, SH3D5 )
Protein Name(s)
  • Sorbin and SH3 domain-containing protein 1
  • Ponsin
  • SH3 domain protein 5
  • SH3P12
  • c-Cbl-associated protein
  • CAP
External Links
UniProt Identifier SRBS1_HUMAN
UniProt Accessions Q9BX66, A0AED4, A6NEK3, A6NID8, A6NJS4, A7MD40, D3DR42, O43857, Q5T923, Q5T924, Q5T927, Q5T928, Q5T929, Q5T930, Q5T931, Q5T932, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338,
EMBL AF136380, AF356525, AF356526, AF356527, AF330623, AF330624, AF136381, AJ489942, AM260536, AB037717, AL117472, AL158165, AL158165, AL158165, AL158165, AL158165, AL158165, AL158165, AL158165, CH471066, CH471066, BC042612, BC152463, U70668,
PIR T17257,
RefSeq NP_001030126.1, NP_001030127.1, NP_001030128.1, NP_001030129.1, NP_006425.2, NP_056200.1, NP_079267.1,
PDB 2DL3, 2ECZ, 2O2W, 2O31, 2O9S, 2O9V,
IntAct Q9BX66,
Ensembl ENST00000361941, ENST00000371227, ENST00000371247,
Pfam PF00018, PF07653, PF02208,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005924

cell-substrate adherens junction

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

GO:0005737

cytoplasm

IEA

C

Source: UniProtKB-KW

GO:0045121

membrane raft

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

GO:0005634

nucleus

IDA: Inferred from Direct Assay

C

Source: UniProtKB

GO:0001725

stress fiber

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

GO:0005915

zonula adherens

TAS: Traceable Author Statement

C

Source: ProtInc

GO:0003779

actin binding

TAS: Traceable Author Statement

F

Source: ProtInc

GO:0005158

insulin receptor binding

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0048041

focal adhesion formation

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

GO:0015758

glucose transport

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

GO:0008286

insulin receptor signaling pathway

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

GO:0043149

stress fiber formation

ISS: Inferred from Sequence or Structural Similarity

P

Source: UniProtKB

GO:0001725

stress fiber

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000097066

C

GO:0001725

stress fiber

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

C

GO:0003779

actin binding

PMID:10085297[1]

TAS: Traceable Author Statement

F

GO:0005070

SH3/SH2 adaptor activity

PMID:11374898[2]

IC: Inferred by Curator

GO:0005158

F

GO:0005070

SH3/SH2 adaptor activity

PMID:9447983[3]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

F

GO:0005158

insulin receptor binding

PMID:11374898[2]

IDA: Inferred from Direct Assay

F

GO:0005515

protein binding

PMID:11371513[4]

IPI: Inferred from Physical Interaction

UniProtKB:O15265

F

GO:0005515

protein binding

PMID:11374898[2]

IPI: Inferred from Physical Interaction

UniProtKB:P00519

F

GO:0005515

protein binding

PMID:11374898[2]

IPI: Inferred from Physical Interaction

UniProtKB:P00519

F

GO:0005515

protein binding

PMID:11374898[2]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

GO:0005515

protein binding

PMID:11374898[2]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

GO:0005515

protein binding

PMID:12504111[5]

IPI: Inferred from Physical Interaction

UniProtKB:O15357

F

GO:0005515

protein binding

PMID:17353931[6]

IPI: Inferred from Physical Interaction

UniProtKB:P56537

F

GO:0005634

nucleus

PMID:11371513[4]

IDA: Inferred from Direct Assay

C

GO:0005634

nucleus

PMID:18029348[7]

IDA: Inferred from Direct Assay

C

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

GO:0005737

cytoplasm

PMID:18029348[7]

IDA: Inferred from Direct Assay

C

GO:0005813

centrosome

PMID:18029348[7]

IDA: Inferred from Direct Assay

C

GO:0005829

cytosol

PMID:9447983[3]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

C

GO:0005829

cytosol

Reactome:REACT_20548

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_20613

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_20643

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_20663

TAS: Traceable Author Statement

C

GO:0005856

cytoskeleton

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0206

C

GO:0005856

cytoskeleton

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0090

C

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

GO:0005886

plasma membrane

PMID:18029348[7]

IDA: Inferred from Direct Assay

C

GO:0005912

adherens junction

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0009

C

GO:0005913

cell-cell adherens junction

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

C

GO:0005913

cell-cell adherens junction

PMID:10085297[1]

TAS: Traceable Author Statement

C

GO:0005915

zonula adherens

PMID:10085297[1]

TAS: Traceable Author Statement

C

GO:0005924

cell-substrate adherens junction

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

C

GO:0005925

focal adhesion

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0118

C

GO:0005925

focal adhesion

PMID:18029348[7]

IDA: Inferred from Direct Assay

C

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

GO:0006936

muscle contraction

Reactome:REACT_20558

TAS: Traceable Author Statement

P

GO:0007160

cell-matrix adhesion

PMID:10085297[1]

TAS: Traceable Author Statement

P

GO:0008092

cytoskeletal protein binding

PMID:10085297[1]

TAS: Traceable Author Statement

F

GO:0008286

insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0015758

glucose transport

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000097066

F

GO:0030054

cell junction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0965

C

GO:0032869

cellular response to insulin stimulus

PMID:11001060[8]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0043149

stress fiber assembly

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0045121

membrane raft

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

C

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:11001060[8]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0046326

positive regulation of glucose import

PMID:11001060[8]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0046889

positive regulation of lipid biosynthetic process

PMID:11001060[8]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0048041

focal adhesion assembly

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

GO:0090004

positive regulation of establishment of protein localization in plasma membrane

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q62417

P

NOT

GO:0005730

nucleolus

PMID:18029348[7]

IDA: Inferred from Direct Assay

C

colocalizes_with

GO:0005899

insulin receptor complex

PMID:11374898[2]

IDA: Inferred from Direct Assay

C


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Mandai K et al. (1999) Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J Cell Biol 144: 1001-17 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Lin WH et al. (2001) Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. Genomics 74: 12-20 PubMed GONUTS page
  3. ↑ 3.0 3.1 Ribon V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18: 872-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 Lebre AS et al. (2001) Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions. Hum Mol Genet 10: 1201-13 PubMed GONUTS page
  5. ↑ Vandenbroere I et al. (2003) The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2. Biochem Biophys Res Commun 300: 494-500 PubMed GONUTS page
  6. ↑ Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Baumann CA et al. (2000) CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407: 202-7 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/HUMAN:SRBS1"
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