GONUTS has been updated to MW1.29.2. Most things seem to be working but be sure to report problems.

It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:IRS1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IRS1
Protein Name(s) Insulin receptor substrate 1

IRS-1

External Links
UniProt P35568
EMBL S85963
S62539
BC053895
CCDS CCDS2463.1
PIR I53160
RefSeq NP_005535.1
UniGene Hs.471508
PDB 1IRS
1K3A
1QQG
2Z8C
PDBsum 1IRS
1K3A
1QQG
2Z8C
ProteinModelPortal P35568
SMR P35568
BioGrid 109874
DIP DIP-523N
IntAct P35568
MINT MINT-149537
STRING 9606.ENSP00000304895
PhosphoSite P35568
BioMuta IRS1
DMDM 547738
MaxQB P35568
PaxDb P35568
PRIDE P35568
DNASU 3667
Ensembl ENST00000305123
GeneID 3667
KEGG hsa:3667
UCSC uc002voh.4
CTD 3667
GeneCards GC02M227563
HGNC HGNC:6125
HPA CAB005261
HPA046433
HPA050221
MIM 125853
147545
neXtProt NX_P35568
PharmGKB PA203
eggNOG NOG81285
GeneTree ENSGT00530000063420
HOGENOM HOG000113103
HOVERGEN HBG000542
InParanoid P35568
KO K16172
OMA HALPHPK
OrthoDB EOG7XM2X6
PhylomeDB P35568
TreeFam TF325994
Reactome REACT_111133
REACT_12464
REACT_147727
REACT_150203
REACT_169118
REACT_508
REACT_524
REACT_570
REACT_75829
REACT_976
SignaLink P35568
ChiTaRS IRS1
EvolutionaryTrace P35568
GeneWiki IRS1
GenomeRNAi 3667
NextBio 14355
PMAP-CutDB P35568
PRO PR:P35568
Proteomes UP000005640
Bgee P35568
CleanEx HS_IRS1
ExpressionAtlas P35568
Genevisible P35568
GO GO:0005901
GO:0036064
GO:0005737
GO:0005829
GO:0005899
GO:0043231
GO:0005634
GO:0005886
GO:0005158
GO:0005159
GO:0043548
GO:0005080
GO:0042169
GO:0004871
GO:0005068
GO:0032869
GO:0007173
GO:0038095
GO:0008543
GO:0042593
GO:0045087
GO:0008286
GO:0048009
GO:0060397
GO:0016042
GO:0030879
GO:0046627
GO:0046676
GO:0048011
GO:0014065
GO:0048015
GO:0030335
GO:0008284
GO:0032000
GO:0046326
GO:2001275
GO:0010907
GO:0045725
GO:0046628
GO:0002053
GO:0043552
GO:0043491
GO:0034504
GO:0010468
GO:0032868
GO:0043434
GO:0007165
Gene3D 2.30.29.30
InterPro IPR002404
IPR011993
IPR001849
Pfam PF02174
PF00169
PRINTS PR00628
SMART SM00233
SM00310
PROSITE PS51064
PS50003

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005901

caveola

IDA: Inferred from Direct Assay

C

Source: UniProtKB

Missing: reference

GO:0005737

cytoplasm

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

Missing: with/from, reference

GO:0005792

microsome

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

Missing: with/from, reference

GO:0005634

nucleus

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

Missing: with/from, reference

GO:0005158

insulin receptor binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0005159

insulin-like growth factor receptor binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0042301

phosphate binding

IDA: Inferred from Direct Assay

F

Source: UniProtKB

Missing: reference

GO:0043548

phosphoinositide 3-kinase binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0042169

SH2 domain binding

ISS: Inferred from Sequence or Structural Similarity

F

Source: UniProtKB

Missing: with/from, reference

GO:0005069

transmembrane receptor protein tyrosine kin...

TAS: Traceable Author Statement

F

Source: ProtInc

Missing: reference

GO:0008286

insulin receptor signaling pathway

IPI: Inferred from Physical Interaction

P

Source: UniProtKB

Missing: with/from, reference

GO:0048009

insulin-like growth factor receptor signali...

IPI: Inferred from Physical Interaction

P

Source: UniProtKB

Missing: with/from, reference

GO:0014065

phosphoinositide 3-kinase cascade

IDA: Inferred from Direct Assay

P

Source: UniProtKB

Missing: reference

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0004871

signal transducer activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

F

complete

GO:0004871

signal transducer activity

PMID:1311924[1]

TAS: Traceable Author Statement

F

complete

GO:0004871

signal transducer activity

PMID:8513971[2]

TAS: Traceable Author Statement

F

complete

GO:0005010

insulin-like growth factor receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

PMID:1648180[3]

TAS: Traceable Author Statement

F

complete

GO:0005080

protein kinase C binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005080

protein kinase C binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0005158

insulin receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002404

F

complete

GO:0005158

insulin receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005158

insulin receptor binding

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

complete

GO:0005158

insulin receptor binding

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

complete

GO:0005159

insulin-like growth factor receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005159

insulin-like growth factor receptor binding

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

F

complete

GO:0005515

protein binding

PMID:11018022[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q8WWQ0

F

complete

GO:0005515

protein binding

PMID:12679424[8]

IPI: Inferred from Physical Interaction

UniProtKB:P26450

F

complete

GO:0005515

protein binding

PMID:12679424[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q60631

F

complete

GO:0005515

protein binding

PMID:17721511[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q08345-2

F

complete

GO:0005515

protein binding

PMID:8388384[10]

IPI: Inferred from Physical Interaction

UniProtKB:P62993

F

complete

GO:0005515

protein binding

PMID:9295312[11]

IPI: Inferred from Physical Interaction

UniProtKB:O14983

F

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005737

cytoplasm

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

complete

GO:0005737

cytoplasm

PMID:1648180[3]

TAS: Traceable Author Statement

C

complete

GO:0005792

microsome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005792

microsome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005792

microsome

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

complete

GO:0005829

cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005829

cytosol

Reactome:REACT_12384

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_169

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_1810

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_2120

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_244

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_26

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_342

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_537

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_562

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_646

TAS: Traceable Author Statement

C

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005886

plasma membrane

Reactome:REACT_12624

TAS: Traceable Author Statement

C

complete

GO:0005899

insulin receptor complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005899

insulin receptor complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

C

complete

GO:0005901

caveola

PMID:15182363[12]

IDA: Inferred from Direct Assay

C

complete

GO:0007165

signal transduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

P

complete

GO:0007165

signal transduction

PMID:1311924[1]

TAS: Traceable Author Statement

P

complete

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0008284

positive regulation of cell proliferation

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

complete

GO:0008286

insulin receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

complete

GO:0008286

insulin receptor signaling pathway

Reactome:REACT_498

TAS: Traceable Author Statement

P

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_9470

TAS: Traceable Author Statement

P

complete

GO:0010468

regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0010907

positive regulation of glucose metabolic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0014065

phosphatidylinositol 3-kinase cascade

PMID:7782332[16]

IDA: Inferred from Direct Assay

P

complete

GO:0016042

lipid catabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

F

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0019904

protein domain specific binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0030335

positive regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0030879

mammary gland development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0032000

positive regulation of fatty acid beta-oxidation

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0032868

response to insulin stimulus

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

complete

GO:0032869

cellular response to insulin stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0032869

cellular response to insulin stimulus

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042169

SH2 domain binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0042169

SH2 domain binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0042327

positive regulation of phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0042593

glucose homeostasis

PMID:16814735[15]

TAS: Traceable Author Statement

P

complete

GO:0043434

response to peptide hormone stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0043434

response to peptide hormone stimulus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:16043515[17]

IPI: Inferred from Physical Interaction

UniProtKB:P26450

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:7782332[16]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

complete

GO:0046326

positive regulation of glucose import

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0046676

negative regulation of insulin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0046676

negative regulation of insulin secretion

PMID:15572028[18]

IDA: Inferred from Direct Assay

P

complete

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Reactome:REACT_12624

TAS: Traceable Author Statement

F

complete

GO:0048009

insulin-like growth factor receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0048009

insulin-like growth factor receptor signaling pathway

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

P

complete

GO:0048011

nerve growth factor receptor signaling pathway

Reactome:REACT_11061

TAS: Traceable Author Statement

P

complete

GO:0048015

phosphatidylinositol-mediated signaling

Reactome:REACT_12464

TAS: Traceable Author Statement

P

complete

GO:0051291

protein heterooligomerization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0070094

positive regulation of glucagon secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0090275

negative regulation of somatostatin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0004871

signal transducer activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0807

F

Seeded From UniProt

complete

GO:0004871

signal transducer activity

PMID:1311924[1]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004871

signal transducer activity

PMID:8513971[2]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

PMID:1648180[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005080

protein kinase C binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0005158

insulin receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002404

F

Seeded From UniProt

complete

GO:0005158

insulin receptor binding

PMID:7493946[19]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005158

insulin receptor binding

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005159

insulin-like growth factor receptor binding

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11018022[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q8WWQ0

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11403293[20]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11416002[21]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14632132[22]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16230374[23]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16273093[24]

IPI: Inferred from Physical Interaction

UniProtKB:P04626

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16582879[25]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18498745[26]

IPI: Inferred from Physical Interaction

UniProtKB:Q8N3Y1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18952604[27]

IPI: Inferred from Physical Interaction

UniProtKB:P23443

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23643389[28]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23643389[28]

IPI: Inferred from Physical Interaction

UniProtKB:P42336

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23770097[29]

IPI: Inferred from Physical Interaction

UniProtKB:P11940

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:24008843[30]

IPI: Inferred from Physical Interaction

UniProtKB:P03495

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25814554[31]

IPI: Inferred from Physical Interaction

UniProtKB:O75815

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25814554[31]

IPI: Inferred from Physical Interaction

UniProtKB:P27986-2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25814554[31]

IPI: Inferred from Physical Interaction

UniProtKB:Q92569

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7513703[32]

IPI: Inferred from Physical Interaction

UniProtKB:Q06124

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7542742[33]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9PVZ4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7680095[34]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7680644[35]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7935368[36]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:8382612[37]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:8388384[10]

IPI: Inferred from Physical Interaction

UniProtKB:P62993

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9295312[11]

IPI: Inferred from Physical Interaction

UniProtKB:O14983

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:1648180[3]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000064809

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_12384

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169213

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169448

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_1810

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_2120

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_244

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_26

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_342

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_537

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_562

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_646

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000064809

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_12624

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_147781

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_147854

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_150135

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_150315

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005899

insulin receptor complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

C

Seeded From UniProt

complete

GO:0005901

caveola

PMID:15182363[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007165

signal transduction

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

GO:0007165

signal transduction

PMID:1311924[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007173

epidermal growth factor receptor signaling pathway

Reactome:REACT_9417

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008284

positive regulation of cell proliferation

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

Reactome:REACT_498

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_252852

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_355200

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_355289

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_355408

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_9470

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0010468

regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0010907

positive regulation of glucose metabolic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0014065

phosphatidylinositol 3-kinase signaling

PMID:7782332[16]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016042

lipid catabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

F

Seeded From UniProt

complete

GO:0030335

positive regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0030879

mammary gland development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0032000

positive regulation of fatty acid beta-oxidation

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032868

response to insulin

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0032869

cellular response to insulin stimulus

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034504

protein localization to nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0036064

ciliary basal body

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0038095

Fc-epsilon receptor signaling pathway

Reactome:REACT_163936

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042169

SH2 domain binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0042593

glucose homeostasis

PMID:16814735[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

Seeded From UniProt

complete

GO:0043434

response to peptide hormone

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0043491

protein kinase B signaling

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:16043515[17]

IPI: Inferred from Physical Interaction

UniProtKB:P26450

F

Seeded From UniProt

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:7782332[16]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0045087

innate immune response

Reactome:REACT_6802

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046326

positive regulation of glucose import

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0046676

negative regulation of insulin secretion

PMID:15572028[18]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048009

insulin-like growth factor receptor signaling pathway

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

P

Seeded From UniProt

complete

GO:0048011

neurotrophin TRK receptor signaling pathway

Reactome:REACT_11061

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048015

phosphatidylinositol-mediated signaling

Reactome:REACT_12464

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0060397

JAK-STAT cascade involved in growth hormone signaling pathway

Reactome:REACT_111133

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:2001275

positive regulation of glucose import in response to insulin stimulus

PMID:7493946[19]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Nishiyama, M & Wands, JR (1992) Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 183 280-5 PubMed GONUTS page
  2. 2.0 2.1 Araki, E et al. (1993) Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. Diabetes 42 1041-54 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Sun, XJ et al. (1991) Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352 73-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Gustafson, TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15 2500-8 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 He, W et al. (1995) Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. J. Biol. Chem. 270 23258-62 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page
  7. 7.0 7.1 Farhang-Fallah, J et al. (2000) Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J. Biol. Chem. 275 40492-7 PubMed GONUTS page
  8. 8.0 8.1 Esposito, DL et al. (2003) A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. J. Clin. Endocrinol. Metab. 88 1468-75 PubMed GONUTS page
  9. Bantscheff, M et al. (2007) Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat. Biotechnol. 25 1035-44 PubMed GONUTS page
  10. 10.0 10.1 Tobe, K et al. (1993) Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. J. Biol. Chem. 268 11167-71 PubMed GONUTS page
  11. 11.0 11.1 Algenstaedt, P et al. (1997) Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. J. Biol. Chem. 272 23696-702 PubMed GONUTS page
  12. 12.0 12.1 Karlsson, M et al. (2004) Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control. Eur. J. Biochem. 271 2471-9 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Danielsson, A et al. (2006) Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes. Biochem. Biophys. Res. Commun. 342 1183-7 PubMed GONUTS page
  15. 15.00 15.01 15.02 15.03 15.04 15.05 15.06 15.07 15.08 15.09 15.10 15.11 15.12 15.13 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page
  17. 17.0 17.1 Luo, J et al. (2005) The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J. Cell Biol. 170 455-64 PubMed GONUTS page
  18. 18.0 18.1 Mohanty, S et al. (2005) Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. Exp. Cell Res. 303 68-78 PubMed GONUTS page
  19. 19.0 19.1 Kharitonenkov, A et al. (1995) Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. J. Biol. Chem. 270 29189-93 PubMed GONUTS page
  20. Ozawa, T et al. (2001) Split luciferase as an optical probe for detecting protein-protein interactions in mammalian cells based on protein splicing. Anal. Chem. 73 2516-21 PubMed GONUTS page
  21. Esposito, DL et al. (2001) Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 142 2833-40 PubMed GONUTS page
  22. Kaihara, A et al. (2003) Locating a protein-protein interaction in living cells via split Renilla luciferase complementation. Anal. Chem. 75 4176-81 PubMed GONUTS page
  23. Asano, T et al. (2005) Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells. Cancer Res. 65 9164-8 PubMed GONUTS page
  24. Jones, RB et al. (2006) A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439 168-74 PubMed GONUTS page
  25. Nouaille, S et al. (2006) Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO Rep. 7 512-8 PubMed GONUTS page
  26. Xu, X et al. (2008) The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol. Cell 30 403-14 PubMed GONUTS page
  27. Zhang, J et al. (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J. Biol. Chem. 283 35375-82 PubMed GONUTS page
  28. 28.0 28.1 Hao, Y et al. (2013) Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions. Cancer Cell 23 583-93 PubMed GONUTS page
  29. Ozoe, A et al. (2013) Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes. FEBS Lett. 587 2319-24 PubMed GONUTS page
  30. de Chassey, B et al. (2013) Structure homology and interaction redundancy for discovering virus-host protein interactions. EMBO Rep. 14 938-44 PubMed GONUTS page
  31. 31.0 31.1 31.2 Grossmann, A et al. (2015) Phospho-tyrosine dependent protein-protein interaction network. Mol. Syst. Biol. 11 794 PubMed GONUTS page
  32. Sugimoto, S et al. (1994) Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. J. Biol. Chem. 269 13614-22 PubMed GONUTS page
  33. Fei, ZL et al. (1995) Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol. Cell. Biol. 15 4232-39 PubMed GONUTS page
  34. Felder, S et al. (1993) SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Mol. Cell. Biol. 13 1449-55 PubMed GONUTS page
  35. Williams, KP & Shoelson, SE (1993) A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. J. Biol. Chem. 268 5361-4 PubMed GONUTS page
  36. O'Neill, TJ et al. (1994) Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol. Cell. Biol. 14 6433-42 PubMed GONUTS page
  37. Shoelson, SE et al. (1993) Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. EMBO J. 12 795-802 PubMed GONUTS page