Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:IRS1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IRS1
Protein Name(s) Insulin receptor substrate 1

IRS-1

External Links
UniProt P35568
EMBL S85963
S62539
BC053895
CCDS CCDS2463.1
PIR I53160
RefSeq NP_005535.1
UniGene Hs.471508
PDB 1IRS
1K3A
1QQG
2Z8C
PDBsum 1IRS
1K3A
1QQG
2Z8C
ProteinModelPortal P35568
SMR P35568
BioGrid 109874
DIP DIP-523N
IntAct P35568
MINT MINT-149537
STRING 9606.ENSP00000304895
PhosphoSite P35568
BioMuta IRS1
DMDM 547738
MaxQB P35568
PaxDb P35568
PRIDE P35568
DNASU 3667
Ensembl ENST00000305123
GeneID 3667
KEGG hsa:3667
UCSC uc002voh.4
CTD 3667
GeneCards GC02M227563
HGNC HGNC:6125
HPA CAB005261
HPA046433
HPA050221
MIM 125853
147545
neXtProt NX_P35568
PharmGKB PA203
eggNOG NOG81285
GeneTree ENSGT00530000063420
HOGENOM HOG000113103
HOVERGEN HBG000542
InParanoid P35568
KO K16172
OMA HALPHPK
OrthoDB EOG7XM2X6
PhylomeDB P35568
TreeFam TF325994
Reactome REACT_111133
REACT_12464
REACT_147727
REACT_150203
REACT_169118
REACT_508
REACT_524
REACT_570
REACT_75829
REACT_976
SignaLink P35568
ChiTaRS IRS1
EvolutionaryTrace P35568
GeneWiki IRS1
GenomeRNAi 3667
NextBio 14355
PMAP-CutDB P35568
PRO PR:P35568
Proteomes UP000005640
Bgee P35568
CleanEx HS_IRS1
ExpressionAtlas P35568
Genevisible P35568
GO GO:0005901
GO:0036064
GO:0005737
GO:0005829
GO:0005899
GO:0043231
GO:0005634
GO:0005886
GO:0005158
GO:0005159
GO:0043548
GO:0005080
GO:0042169
GO:0004871
GO:0005068
GO:0032869
GO:0007173
GO:0038095
GO:0008543
GO:0042593
GO:0045087
GO:0008286
GO:0048009
GO:0060397
GO:0016042
GO:0030879
GO:0046627
GO:0046676
GO:0048011
GO:0014065
GO:0048015
GO:0030335
GO:0008284
GO:0032000
GO:0046326
GO:2001275
GO:0010907
GO:0045725
GO:0046628
GO:0002053
GO:0043552
GO:0043491
GO:0034504
GO:0010468
GO:0032868
GO:0043434
GO:0007165
Gene3D 2.30.29.30
InterPro IPR002404
IPR011993
IPR001849
Pfam PF02174
PF00169
PRINTS PR00628
SMART SM00233
SM00310
PROSITE PS51064
PS50003

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005901

caveola

IDA: Inferred from Direct Assay

C

Source: UniProtKB

Missing: reference

GO:0005737

cytoplasm

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

Missing: with/from, reference

GO:0005792

microsome

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

Missing: with/from, reference

GO:0005634

nucleus

ISS: Inferred from Sequence or Structural Similarity

C

Source: UniProtKB

Missing: with/from, reference

GO:0005158

insulin receptor binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0005159

insulin-like growth factor receptor binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0042301

phosphate binding

IDA: Inferred from Direct Assay

F

Source: UniProtKB

Missing: reference

GO:0043548

phosphoinositide 3-kinase binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

Missing: with/from, reference

GO:0042169

SH2 domain binding

ISS: Inferred from Sequence or Structural Similarity

F

Source: UniProtKB

Missing: with/from, reference

GO:0005069

transmembrane receptor protein tyrosine kin...

TAS: Traceable Author Statement

F

Source: ProtInc

Missing: reference

GO:0008286

insulin receptor signaling pathway

IPI: Inferred from Physical Interaction

P

Source: UniProtKB

Missing: with/from, reference

GO:0048009

insulin-like growth factor receptor signali...

IPI: Inferred from Physical Interaction

P

Source: UniProtKB

Missing: with/from, reference

GO:0014065

phosphoinositide 3-kinase cascade

IDA: Inferred from Direct Assay

P

Source: UniProtKB

Missing: reference

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0004871

signal transducer activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

F

complete

GO:0004871

signal transducer activity

PMID:1311924[1]

TAS: Traceable Author Statement

F

complete

GO:0004871

signal transducer activity

PMID:8513971[2]

TAS: Traceable Author Statement

F

complete

GO:0005010

insulin-like growth factor receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

PMID:1648180[3]

TAS: Traceable Author Statement

F

complete

GO:0005080

protein kinase C binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005080

protein kinase C binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0005158

insulin receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002404

F

complete

GO:0005158

insulin receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005158

insulin receptor binding

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

complete

GO:0005158

insulin receptor binding

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

complete

GO:0005159

insulin-like growth factor receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0005159

insulin-like growth factor receptor binding

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

F

complete

GO:0005515

protein binding

PMID:11018022[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q8WWQ0

F

complete

GO:0005515

protein binding

PMID:12679424[8]

IPI: Inferred from Physical Interaction

UniProtKB:P26450

F

complete

GO:0005515

protein binding

PMID:12679424[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q60631

F

complete

GO:0005515

protein binding

PMID:17721511[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q08345-2

F

complete

GO:0005515

protein binding

PMID:8388384[10]

IPI: Inferred from Physical Interaction

UniProtKB:P62993

F

complete

GO:0005515

protein binding

PMID:9295312[11]

IPI: Inferred from Physical Interaction

UniProtKB:O14983

F

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005737

cytoplasm

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

complete

GO:0005737

cytoplasm

PMID:1648180[3]

TAS: Traceable Author Statement

C

complete

GO:0005792

microsome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005792

microsome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005792

microsome

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

complete

GO:0005829

cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005829

cytosol

Reactome:REACT_12384

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_169

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_1810

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_2120

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_244

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_26

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_342

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_537

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_562

TAS: Traceable Author Statement

C

complete

GO:0005829

cytosol

Reactome:REACT_646

TAS: Traceable Author Statement

C

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005886

plasma membrane

Reactome:REACT_12624

TAS: Traceable Author Statement

C

complete

GO:0005899

insulin receptor complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

C

complete

GO:0005899

insulin receptor complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

C

complete

GO:0005901

caveola

PMID:15182363[12]

IDA: Inferred from Direct Assay

C

complete

GO:0007165

signal transduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

P

complete

GO:0007165

signal transduction

PMID:1311924[1]

TAS: Traceable Author Statement

P

complete

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0008284

positive regulation of cell proliferation

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

complete

GO:0008286

insulin receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

complete

GO:0008286

insulin receptor signaling pathway

Reactome:REACT_498

TAS: Traceable Author Statement

P

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_9470

TAS: Traceable Author Statement

P

complete

GO:0010468

regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0010907

positive regulation of glucose metabolic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0014065

phosphatidylinositol 3-kinase cascade

PMID:7782332[16]

IDA: Inferred from Direct Assay

P

complete

GO:0016042

lipid catabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

F

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0019904

protein domain specific binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0030335

positive regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0030879

mammary gland development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0032000

positive regulation of fatty acid beta-oxidation

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0032868

response to insulin stimulus

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

complete

GO:0032869

cellular response to insulin stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0032869

cellular response to insulin stimulus

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042169

SH2 domain binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0042169

SH2 domain binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0042327

positive regulation of phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0042593

glucose homeostasis

PMID:16814735[15]

TAS: Traceable Author Statement

P

complete

GO:0043434

response to peptide hormone stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0043434

response to peptide hormone stimulus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:16043515[17]

IPI: Inferred from Physical Interaction

UniProtKB:P26450

F

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:7782332[16]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

complete

GO:0046326

positive regulation of glucose import

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

complete

GO:0046676

negative regulation of insulin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0046676

negative regulation of insulin secretion

PMID:15572028[18]

IDA: Inferred from Direct Assay

P

complete

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Reactome:REACT_12624

TAS: Traceable Author Statement

F

complete

GO:0048009

insulin-like growth factor receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0048009

insulin-like growth factor receptor signaling pathway

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

P

complete

GO:0048011

nerve growth factor receptor signaling pathway

Reactome:REACT_11061

TAS: Traceable Author Statement

P

complete

GO:0048015

phosphatidylinositol-mediated signaling

Reactome:REACT_12464

TAS: Traceable Author Statement

P

complete

GO:0051291

protein heterooligomerization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0070094

positive regulation of glucagon secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0090275

negative regulation of somatostatin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000019579

P

complete

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0004871

signal transducer activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0807

F

Seeded From UniProt

complete

GO:0004871

signal transducer activity

PMID:1311924[1]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0004871

signal transducer activity

PMID:8513971[2]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0005068

transmembrane receptor protein tyrosine kinase adaptor activity

PMID:1648180[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005080

protein kinase C binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0005158

insulin receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002404

F

Seeded From UniProt

complete

GO:0005158

insulin receptor binding

PMID:7493946[19]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005158

insulin receptor binding

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005159

insulin-like growth factor receptor binding

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11018022[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q8WWQ0

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11403293[20]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11416002[21]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14632132[22]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16230374[23]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16273093[24]

IPI: Inferred from Physical Interaction

UniProtKB:P04626

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16582879[25]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18498745[26]

IPI: Inferred from Physical Interaction

UniProtKB:Q8N3Y1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18952604[27]

IPI: Inferred from Physical Interaction

UniProtKB:P23443

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23643389[28]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23643389[28]

IPI: Inferred from Physical Interaction

UniProtKB:P42336

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23770097[29]

IPI: Inferred from Physical Interaction

UniProtKB:P11940

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:24008843[30]

IPI: Inferred from Physical Interaction

UniProtKB:P03495

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25814554[31]

IPI: Inferred from Physical Interaction

UniProtKB:O75815

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25814554[31]

IPI: Inferred from Physical Interaction

UniProtKB:P27986-2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25814554[31]

IPI: Inferred from Physical Interaction

UniProtKB:Q92569

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7513703[32]

IPI: Inferred from Physical Interaction

UniProtKB:Q06124

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7542742[33]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q9PVZ4

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7680095[34]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7680644[35]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7935368[36]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:8382612[37]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:8388384[10]

IPI: Inferred from Physical Interaction

UniProtKB:P62993

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9295312[11]

IPI: Inferred from Physical Interaction

UniProtKB:O14983

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:1648180[3]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000064809

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_12384

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169213

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_169448

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_1810

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_2120

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_244

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_26

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_342

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_537

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_562

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_646

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000064809

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_12624

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_147781

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_147854

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_150135

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

Reactome:REACT_150315

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005899

insulin receptor complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

C

Seeded From UniProt

complete

GO:0005901

caveola

PMID:15182363[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007165

signal transduction

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

GO:0007165

signal transduction

PMID:1311924[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007173

epidermal growth factor receptor signaling pathway

Reactome:REACT_9417

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008284

positive regulation of cell proliferation

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:7537849[4]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:7559478[5]

IPI: Inferred from Physical Interaction

UniProtKB:P06213

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

Reactome:REACT_498

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_252852

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_355200

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_355289

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_355408

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_9470

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0010468

regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0010907

positive regulation of glucose metabolic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0014065

phosphatidylinositol 3-kinase signaling

PMID:7782332[16]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016042

lipid catabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

F

Seeded From UniProt

complete

GO:0030335

positive regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0030879

mammary gland development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0032000

positive regulation of fatty acid beta-oxidation

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032868

response to insulin

PMID:16516141[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0032869

cellular response to insulin stimulus

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034504

protein localization to nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0036064

ciliary basal body

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

C

Seeded From UniProt

complete

GO:0038095

Fc-epsilon receptor signaling pathway

Reactome:REACT_163936

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042169

SH2 domain binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0042593

glucose homeostasis

PMID:16814735[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35569

C

Seeded From UniProt

complete

GO:0043434

response to peptide hormone

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0043491

protein kinase B signaling

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

F

Seeded From UniProt

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:16043515[17]

IPI: Inferred from Physical Interaction

UniProtKB:P26450

F

Seeded From UniProt

complete

GO:0043548

phosphatidylinositol 3-kinase binding

PMID:7782332[16]

IPI: Inferred from Physical Interaction

UniProtKB:P27986

F

Seeded From UniProt

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000063795

P

Seeded From UniProt

complete

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0045087

innate immune response

Reactome:REACT_6802

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045725

positive regulation of glycogen biosynthetic process

PMID:17925406[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046326

positive regulation of glucose import

PMID:16814735[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P35570

P

Seeded From UniProt

complete

GO:0046676

negative regulation of insulin secretion

PMID:15572028[18]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048009

insulin-like growth factor receptor signaling pathway

PMID:7541045[6]

IPI: Inferred from Physical Interaction

UniProtKB:P08069

P

Seeded From UniProt

complete

GO:0048011

neurotrophin TRK receptor signaling pathway

Reactome:REACT_11061

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048015

phosphatidylinositol-mediated signaling

Reactome:REACT_12464

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0060397

JAK-STAT cascade involved in growth hormone signaling pathway

Reactome:REACT_111133

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:2001275

positive regulation of glucose import in response to insulin stimulus

PMID:7493946[19]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Nishiyama, M & Wands, JR (1992) Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 183 280-5 PubMed GONUTS page
  2. 2.0 2.1 Araki, E et al. (1993) Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. Diabetes 42 1041-54 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Sun, XJ et al. (1991) Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352 73-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Gustafson, TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15 2500-8 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 He, W et al. (1995) Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. J. Biol. Chem. 270 23258-62 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page
  7. 7.0 7.1 Farhang-Fallah, J et al. (2000) Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J. Biol. Chem. 275 40492-7 PubMed GONUTS page
  8. 8.0 8.1 Esposito, DL et al. (2003) A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. J. Clin. Endocrinol. Metab. 88 1468-75 PubMed GONUTS page
  9. Bantscheff, M et al. (2007) Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat. Biotechnol. 25 1035-44 PubMed GONUTS page
  10. 10.0 10.1 Tobe, K et al. (1993) Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. J. Biol. Chem. 268 11167-71 PubMed GONUTS page
  11. 11.0 11.1 Algenstaedt, P et al. (1997) Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. J. Biol. Chem. 272 23696-702 PubMed GONUTS page
  12. 12.0 12.1 Karlsson, M et al. (2004) Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control. Eur. J. Biochem. 271 2471-9 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Danielsson, A et al. (2006) Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes. Biochem. Biophys. Res. Commun. 342 1183-7 PubMed GONUTS page
  15. 15.00 15.01 15.02 15.03 15.04 15.05 15.06 15.07 15.08 15.09 15.10 15.11 15.12 15.13 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page
  17. 17.0 17.1 Luo, J et al. (2005) The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J. Cell Biol. 170 455-64 PubMed GONUTS page
  18. 18.0 18.1 Mohanty, S et al. (2005) Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. Exp. Cell Res. 303 68-78 PubMed GONUTS page
  19. 19.0 19.1 Kharitonenkov, A et al. (1995) Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. J. Biol. Chem. 270 29189-93 PubMed GONUTS page
  20. Ozawa, T et al. (2001) Split luciferase as an optical probe for detecting protein-protein interactions in mammalian cells based on protein splicing. Anal. Chem. 73 2516-21 PubMed GONUTS page
  21. Esposito, DL et al. (2001) Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 142 2833-40 PubMed GONUTS page
  22. Kaihara, A et al. (2003) Locating a protein-protein interaction in living cells via split Renilla luciferase complementation. Anal. Chem. 75 4176-81 PubMed GONUTS page
  23. Asano, T et al. (2005) Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells. Cancer Res. 65 9164-8 PubMed GONUTS page
  24. Jones, RB et al. (2006) A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439 168-74 PubMed GONUTS page
  25. Nouaille, S et al. (2006) Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO Rep. 7 512-8 PubMed GONUTS page
  26. Xu, X et al. (2008) The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol. Cell 30 403-14 PubMed GONUTS page
  27. Zhang, J et al. (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J. Biol. Chem. 283 35375-82 PubMed GONUTS page
  28. 28.0 28.1 Hao, Y et al. (2013) Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions. Cancer Cell 23 583-93 PubMed GONUTS page
  29. Ozoe, A et al. (2013) Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes. FEBS Lett. 587 2319-24 PubMed GONUTS page
  30. de Chassey, B et al. (2013) Structure homology and interaction redundancy for discovering virus-host protein interactions. EMBO Rep. 14 938-44 PubMed GONUTS page
  31. 31.0 31.1 31.2 Grossmann, A et al. (2015) Phospho-tyrosine dependent protein-protein interaction network. Mol. Syst. Biol. 11 794 PubMed GONUTS page
  32. Sugimoto, S et al. (1994) Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. J. Biol. Chem. 269 13614-22 PubMed GONUTS page
  33. Fei, ZL et al. (1995) Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Mol. Cell. Biol. 15 4232-39 PubMed GONUTS page
  34. Felder, S et al. (1993) SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Mol. Cell. Biol. 13 1449-55 PubMed GONUTS page
  35. Williams, KP & Shoelson, SE (1993) A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. J. Biol. Chem. 268 5361-4 PubMed GONUTS page
  36. O'Neill, TJ et al. (1994) Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol. Cell. Biol. 14 6433-42 PubMed GONUTS page
  37. Shoelson, SE et al. (1993) Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. EMBO J. 12 795-802 PubMed GONUTS page