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YEAST:YOR22
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Probable phospholipase YOR022C, mitochondrial | |
| External Links | ||
| UniProt | Q12204 | |
| EMBL | X87331 Z74930 BK006948 | |
| PIR | S54628 | |
| RefSeq | NP_014665.1 | |
| ProteinModelPortal | Q12204 | |
| SMR | Q12204 | |
| BioGrid | 34426 | |
| MINT | MINT-4502424 | |
| iPTMnet | Q12204 | |
| MaxQB | Q12204 | |
| PeptideAtlas | Q12204 | |
| EnsemblFungi | YOR022C | |
| GeneID | 854187 | |
| KEGG | sce:YOR022C | |
| EuPathDB | FungiDB:YOR022C | |
| SGD | S000005548 | |
| GeneTree | ENSGT00530000063155 | |
| HOGENOM | HOG000093626 | |
| InParanoid | Q12204 | |
| OMA | ITWRHSI | |
| OrthoDB | EOG7J44G4 | |
| BioCyc | YEAST:G3O-33570-MONOMER | |
| Reactome | [www.reactome.org/content/detail/R-SCE-1483166 R-SCE-1483166] [www.reactome.org/content/detail/R-SCE-204005 R-SCE-204005] | |
| PRO | PR:Q12204 | |
| Proteomes | UP000002311 | |
| GO | GO:0005739 GO:0046872 GO:0004620 GO:0016042 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR004177 | |
| Pfam | PF02862 | |
| SMART | SM01127 | |
| SUPFAM | SSF53474 | |
| PROSITE | PS51043 PS00120 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008970 |
phosphatidylcholine 1-acylhydrolase activity |
ECO:0000314 |
F |
The author used mass spectrometry analysis on Yor022c and three different synthetic phospholipids and found that Yor022c cleaved at specifically the sn-1-position indicating that it is a phosphatidylcholine 1-acylhydrolase (Figure 2). |
complete | |||||
| GO:0005759 |
mitochondrial matrix |
ECO:0000314 |
C |
The author purified mitochondria and created three groups of mitochondria that were left intact, had their outer membranes ruptured, and had their entire membrane dissolved. The author then treated the groups of mitochondria with proteinase K and performed a western blot. It was found from the western blot that the only time Yor022c was degraded by proteinase K was when the entire mitochondrial membrane was dissolved indicating that Yor022c was localized to the mitochondrial matrix (Figure 4b). |
complete | |||||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004620 |
phospholipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:28494)|has_direct_input:(CHEBI:16038)|has_direct_input:(CHEBI:17517) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004620 |
phospholipase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046337 |
phosphatidylethanolamine metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032048 |
cardiolipin metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006644 |
phospholipid metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004620 |
phospholipase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
protein_id:AAC03019.1 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004620 |
phospholipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:64482)|has_direct_input:(CHEBI:16038)|has_direct_input:(CHEBI:16337) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004620 |
phospholipase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0031990 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Urafuji, K & Arioka, M (2016) Yor022c protein is a phospholipase A1 that localizes to the mitochondrial matrix. Biochem. Biophys. Res. Commun. PubMed GONUTS page
- ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
- ↑ Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page
- ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Yadav, PK & Rajasekharan, R (2016) Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast. J. Biol. Chem. 291 18562-81 PubMed GONUTS page
- ↑ Higgs, HN et al. (1998) Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis. J. Biol. Chem. 273 5468-77 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
