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YEAST:XRN1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) XRN1 (synonyms: DST2, KEM1, RAR5, SEP1, SKI1)
Protein Name(s) 5'-3' exoribonuclease 1

DNA strand transfer protein beta STP-beta KAR(-)-enhancing mutation protein Strand exchange protein 1 p175

External Links
UniProt P22147
EMBL M90097
X54717
M58367
M36725
X61181
X84705
Z72695
BK006941
PIR S13743
RefSeq NP_011342.1
ProteinModelPortal P22147
BioGrid 33080
DIP DIP-656N
IntAct P22147
MINT MINT-414332
STRING 4932.YGL173C
MaxQB P22147
PaxDb P22147
PeptideAtlas P22147
EnsemblFungi [example_ID YGL173C]
GeneID 852702
KEGG sce:YGL173C
CYGD YGL173c
SGD S000003141
eggNOG COG5049
GeneTree ENSGT00670000098080
HOGENOM HOG000160331
KO K12618
OMA NIFAYIE
OrthoDB EOG71RXT2
BioCyc YEAST:G3O-30661-MONOMER
Reactome REACT_249345
NextBio 972050
PRO PR:P22147
Proteomes UP000002311
Genevestigator P22147
GO GO:0005737
GO:0000932
GO:0010494
GO:0005829
GO:0005874
GO:0005634
GO:0048471
GO:0004534
GO:0003682
GO:0003723
GO:0000741
GO:0070651
GO:0000956
GO:0000184
GO:0032968
GO:0060261
GO:0090503
GO:0006364
GO:0007089
InterPro IPR027073
IPR016494
IPR004859
PANTHER PTHR12341
Pfam PF03159
PIRSF PIRSF006743

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0003729

mRNA binding

PMID:23222640[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016242

negative regulation of macroautophagy

PMID:29465287[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0006995)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14562095[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:25811606[4]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0033554)

Seeded From UniProt

complete

part_of

GO:0090512

eisosome membrane domain/MCC

PMID:25811606[4]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0042149)

Seeded From UniProt

complete

involved_in

GO:0061157

mRNA destabilization

PMID:24567736[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006364

rRNA processing

PMID:9488433[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006364

rRNA processing

PMID:9488433[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q02792

P

Seeded From UniProt

complete

involved_in

GO:0043144

snoRNA processing

PMID:9488433[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q02792

P

Seeded From UniProt

complete

involved_in

GO:0000956

nuclear-transcribed mRNA catabolic process

PMID:24119399[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070651

nonfunctional rRNA decay

PMID:19481524[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060261

positive regulation of transcription initiation from RNA polymerase II promoter

PMID:23706738[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:23706738[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0010494

cytoplasmic stress granule

PMID:23222640[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0042149)

Seeded From UniProt

complete

involved_in

GO:0007089

traversing start control point of mitotic cell cycle

PMID:16240118[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:23706738[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23706738[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004534

5'-3' exoribonuclease activity

PMID:1979303[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004534

5'-3' exoribonuclease activity

PMID:3545079[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:23706738[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:12730603[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000932

P-body

PMID:12730603[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

PMID:10848586[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004527

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008409

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004527

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

involved_in

GO:0090503

RNA phosphodiester bond hydrolysis, exonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004534

P

Seeded From UniProt

complete

involved_in

GO:0090503

RNA phosphodiester bond hydrolysis, exonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004534

P

Seeded From UniProt

complete

involved_in

GO:0090503

RNA phosphodiester bond hydrolysis, exonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004534

P

Seeded From UniProt

complete

involved_in

GO:0000956

nuclear-transcribed mRNA catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016494

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004859

F

Seeded From UniProt

complete

enables

GO:0004527

exonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004859

F

Seeded From UniProt

complete

enables

GO:0008409

5'-3' exonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016494

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-SCE-429913

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004534

5'-3' exoribonuclease activity

Reactome:R-SCE-429913

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0866

P

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

enables

GO:0004527

exonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0269

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0006364

rRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0698

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

involved_in

GO:0000741

karyogamy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0415

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

part_of

GO:0000932

P-body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0230

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Mitchell, SF et al. (2013) Global analysis of yeast mRNPs. Nat. Struct. Mol. Biol. 20 127-33 PubMed GONUTS page
  2. Delorme-Axford, E et al. (2018) The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Autophagy 14 898-912 PubMed GONUTS page
  3. Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
  4. 4.0 4.1 Grousl, T et al. (2015) Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. PLoS ONE 10 e0122770 PubMed GONUTS page
  5. Medina, DA et al. (2014) Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast. Front Genet 5 1 PubMed GONUTS page
  6. 6.0 6.1 6.2 Petfalski, E et al. (1998) Processing of the precursors to small nucleolar RNAs and rRNAs requires common components. Mol. Cell. Biol. 18 1181-9 PubMed GONUTS page
  7. Sun, M et al. (2013) Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels. Mol. Cell 52 52-62 PubMed GONUTS page
  8. Cole, SE et al. (2009) A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay. Mol. Cell 34 440-50 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Haimovich, G et al. (2013) Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis. Cell 153 1000-11 PubMed GONUTS page
  10. Pathak, R et al. (2005) A role for KEM1 at the START of the cell cycle in Saccharomyces cerevisiae. Curr. Genet. 48 300-9 PubMed GONUTS page
  11. Larimer, FW & Stevens, A (1990) Disruption of the gene XRN1, coding for a 5'----3' exoribonuclease, restricts yeast cell growth. Gene 95 85-90 PubMed GONUTS page
  12. Stevens, A & Maupin, MK (1987) A 5'----3' exoribonuclease of Saccharomyces cerevisiae: size and novel substrate specificity. Arch. Biochem. Biophys. 252 339-47 PubMed GONUTS page
  13. 13.0 13.1 Sheth, U & Parker, R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300 805-8 PubMed GONUTS page
  14. Maderazo, AB et al. (2000) Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p. Mol. Cell. Biol. 20 4591-603 PubMed GONUTS page