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YEAST:XRN1
Contents
Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
Gene Name(s) | XRN1 (synonyms: DST2, KEM1, RAR5, SEP1, SKI1) | |
Protein Name(s) | 5'-3' exoribonuclease 1
DNA strand transfer protein beta STP-beta KAR(-)-enhancing mutation protein Strand exchange protein 1 p175 | |
External Links | ||
UniProt | P22147 | |
EMBL | M90097 X54717 M58367 M36725 X61181 X84705 Z72695 BK006941 | |
PIR | S13743 | |
RefSeq | NP_011342.1 | |
ProteinModelPortal | P22147 | |
BioGrid | 33080 | |
DIP | DIP-656N | |
IntAct | P22147 | |
MINT | MINT-414332 | |
STRING | 4932.YGL173C | |
MaxQB | P22147 | |
PaxDb | P22147 | |
PeptideAtlas | P22147 | |
EnsemblFungi | [example_ID YGL173C] | |
GeneID | 852702 | |
KEGG | sce:YGL173C | |
CYGD | YGL173c | |
SGD | S000003141 | |
eggNOG | COG5049 | |
GeneTree | ENSGT00670000098080 | |
HOGENOM | HOG000160331 | |
KO | K12618 | |
OMA | NIFAYIE | |
OrthoDB | EOG71RXT2 | |
BioCyc | YEAST:G3O-30661-MONOMER | |
Reactome | REACT_249345 | |
NextBio | 972050 | |
PRO | PR:P22147 | |
Proteomes | UP000002311 | |
Genevestigator | P22147 | |
GO | GO:0005737 GO:0000932 GO:0010494 GO:0005829 GO:0005874 GO:0005634 GO:0048471 GO:0004534 GO:0003682 GO:0003723 GO:0000741 GO:0070651 GO:0000956 GO:0000184 GO:0032968 GO:0060261 GO:0090503 GO:0006364 GO:0007089 | |
InterPro | IPR027073 IPR016494 IPR004859 | |
PANTHER | PTHR12341 | |
Pfam | PF03159 | |
PIRSF | PIRSF006743 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0003729 |
mRNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016242 |
negative regulation of macroautophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
part_of:(GO:0006995) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000932 |
P-body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0033554) |
Seeded From UniProt |
complete | ||
part_of |
GO:0090512 |
eisosome membrane domain/MCC |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0042149) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061157 |
mRNA destabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043144 |
snoRNA processing |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000956 |
nuclear-transcribed mRNA catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070651 |
nonfunctional rRNA decay |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060261 |
positive regulation of transcription initiation from RNA polymerase II promoter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0042149) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007089 |
traversing start control point of mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004534 |
5'-3' exoribonuclease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004534 |
5'-3' exoribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000932 |
P-body |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000932 |
P-body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000184 |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004527 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008409 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004527 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004518 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090503 |
RNA phosphodiester bond hydrolysis, exonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004534 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090503 |
RNA phosphodiester bond hydrolysis, exonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004534 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090503 |
RNA phosphodiester bond hydrolysis, exonucleolytic |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004534 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000956 |
nuclear-transcribed mRNA catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004527 |
exonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008409 |
5'-3' exonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
Reactome:R-SCE-429913 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004534 |
5'-3' exoribonuclease activity |
Reactome:R-SCE-429913 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000184 |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004527 |
exonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005874 |
microtubule |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000741 |
karyogamy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000932 |
P-body |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mitchell, SF et al. (2013) Global analysis of yeast mRNPs. Nat. Struct. Mol. Biol. 20 127-33 PubMed GONUTS page
- ↑ Delorme-Axford, E et al. (2018) The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Autophagy 14 898-912 PubMed GONUTS page
- ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
- ↑ 4.0 4.1 Grousl, T et al. (2015) Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. PLoS ONE 10 e0122770 PubMed GONUTS page
- ↑ Medina, DA et al. (2014) Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast. Front Genet 5 1 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Petfalski, E et al. (1998) Processing of the precursors to small nucleolar RNAs and rRNAs requires common components. Mol. Cell. Biol. 18 1181-9 PubMed GONUTS page
- ↑ Sun, M et al. (2013) Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels. Mol. Cell 52 52-62 PubMed GONUTS page
- ↑ Cole, SE et al. (2009) A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay. Mol. Cell 34 440-50 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Haimovich, G et al. (2013) Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis. Cell 153 1000-11 PubMed GONUTS page
- ↑ Pathak, R et al. (2005) A role for KEM1 at the START of the cell cycle in Saccharomyces cerevisiae. Curr. Genet. 48 300-9 PubMed GONUTS page
- ↑ Larimer, FW & Stevens, A (1990) Disruption of the gene XRN1, coding for a 5'----3' exoribonuclease, restricts yeast cell growth. Gene 95 85-90 PubMed GONUTS page
- ↑ Stevens, A & Maupin, MK (1987) A 5'----3' exoribonuclease of Saccharomyces cerevisiae: size and novel substrate specificity. Arch. Biochem. Biophys. 252 339-47 PubMed GONUTS page
- ↑ 13.0 13.1 Sheth, U & Parker, R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300 805-8 PubMed GONUTS page
- ↑ Maderazo, AB et al. (2000) Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p. Mol. Cell. Biol. 20 4591-603 PubMed GONUTS page
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- GO:0016242 ! negative regulation of macroautophagy
- GO:0070651 ! nonfunctional rRNA decay
- GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- GO:0000956 ! nuclear-transcribed mRNA catabolic process
- GO:0004518 ! nuclease activity
- GO:0003676 ! nucleic acid binding
- GO:0005634 ! nucleus
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