YEAST:VAC14

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	VAC14 (synonyms: SVP2)
Protein Name(s)	Vacuole morphology and inheritance protein 14 Swollen vacuole phenotype 2 protein
External Links
UniProt	Q06708
EMBL	U19104 BK006945
PIR	S51473
RefSeq	NP_013490.3
ProteinModelPortal	Q06708
SMR	Q06708
BioGrid	31645
DIP	DIP-1176N
IntAct	Q06708
MINT	MINT-401035
STRING	4932.YLR386W
MaxQB	Q06708
PaxDb	Q06708
PeptideAtlas	Q06708
EnsemblFungi	[example_ID YLR386W]
GeneID	851102
KEGG	sce:YLR386W
CYGD	YLR386w
SGD	S000004378
eggNOG	NOG287585
GeneTree	ENSGT00390000008385
HOGENOM	HOG000216640
InParanoid	Q06708
KO	K15305
OMA	CIEKEED
OrthoDB	EOG70PC63
BioCyc	MetaCyc:MONOMER-15185 YEAST:G3O-32452-MONOMER
Reactome	REACT_188955 REACT_188958 REACT_188968
NextBio	967794
PRO	PR:Q06708
Proteomes	UP000002311
Genevestigator	Q06708
GO	GO:0000306 GO:0000329 GO:0070772 GO:0042802 GO:0030674 GO:0006661 GO:0033674 GO:0015031 GO:0043550
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000357 IPR021133 IPR026825 IPR021841
PANTHER	PTHR16023
Pfam	PF02985 PF11916
SUPFAM	SSF48371
PROSITE	PS50077

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0032947	protein-containing complex scaffold activity	PMID:19037259^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P34756 UniProtKB:P42837 UniProtKB:P43601 UniProtKB:P53950	F		Seeded From UniProt	complete
involved_in	GO:0090218	positive regulation of lipid kinase activity	PMID:14528018^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000004999,SGD:S000005269	P	has_input:(UniProtKB:P34756)	Seeded From UniProt	complete
involved_in	GO:1903778	protein localization to vacuolar membrane	PMID:14528018^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P42837)	Seeded From UniProt	complete
part_of	GO:0070772	PAS complex	PMID:19037259^[1]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000001915 SGD:S000001917 SGD:S000004999 SGD:S000005269	C		Seeded From UniProt	complete
part_of	GO:0070772	PAS complex	PMID:19037259^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090218	positive regulation of lipid kinase activity	PMID:11889142^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001915	P	part_of:(GO:0071474) has_input:(UniProtKB:P34756)	Seeded From UniProt	complete
involved_in	GO:0090218	positive regulation of lipid kinase activity	PMID:11889142^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071474) has_input:(UniProtKB:P34756)	Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:19037259^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:19037259^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	PMID:11889142^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001915	P		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	PMID:11889142^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000329	fungal-type vacuole membrane	PMID:11889142^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000329	fungal-type vacuole membrane	PMID:14528018^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000329	fungal-type vacuole membrane	PMID:23708375^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000306	extrinsic component of vacuolar membrane	PMID:11889142^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070772	PAS complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000410974 SGD:S000004378	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000410974 UniProtKB:Q08AM6	C		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000410974 SGD:S000004378	P		Seeded From UniProt	complete
part_of	GO:0000329	fungal-type vacuole membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001042179 SGD:S000004378	C		Seeded From UniProt	complete
part_of	GO:0000306	extrinsic component of vacuolar membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000410974 SGD:S000004378	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19037259^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06708	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18719252^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06708	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12062051^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q06708	F		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026825	P		Seeded From UniProt	complete
part_of	GO:0070772	PAS complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026825	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005773	vacuole	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0926	C		Seeded From UniProt	complete
part_of	GO:0005774	vacuolar membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0271	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Jin, N et al. (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 27 3221-34 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Rudge, SA et al. (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol. Biol. Cell 15 24-36 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Bonangelino, CJ et al. (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J. Cell Biol. 156 1015-28 PubMed GONUTS page
↑ Matsumoto, R et al. (2013) Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Protoplasma 250 1283-93 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yu, H et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322 104-10 PubMed GONUTS page
↑ Dove, SK et al. (2002) Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body. Curr. Biol. 12 885-93 PubMed GONUTS page

[PMID:19037259-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Jin, N et al. (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 27 3221-34 PubMed GONUTS page

[PMID:14528018-2] 2.0 ^2.1 ^2.2 Rudge, SA et al. (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol. Biol. Cell 15 24-36 PubMed GONUTS page

[PMID:11889142-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Bonangelino, CJ et al. (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J. Cell Biol. 156 1015-28 PubMed GONUTS page

[PMID:23708375-4] Matsumoto, R et al. (2013) Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Protoplasma 250 1283-93 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18719252-6] Yu, H et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322 104-10 PubMed GONUTS page

[PMID:12062051-7] Dove, SK et al. (2002) Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body. Curr. Biol. 12 885-93 PubMed GONUTS page

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YEAST:VAC14

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