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YEAST:UTP18
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | UTP18 | |
| Protein Name(s) | U3 small nucleolar RNA-associated protein 18
U3 snoRNA-associated protein 18 U three protein 18 | |
| External Links | ||
| UniProt | P40362 | |
| EMBL | Z34288 Z49344 X88851 AY692560 BK006943 | |
| PIR | S50802 | |
| RefSeq | NP_012466.1 | |
| ProteinModelPortal | P40362 | |
| SMR | P40362 | |
| BioGrid | 33686 | |
| DIP | DIP-6392N | |
| IntAct | P40362 | |
| MINT | MINT-561650 | |
| iPTMnet | P40362 | |
| MaxQB | P40362 | |
| PeptideAtlas | P40362 | |
| EnsemblFungi | YJL069C | |
| GeneID | 853376 | |
| KEGG | sce:YJL069C | |
| EuPathDB | FungiDB:YJL069C | |
| SGD | S000003605 | |
| GeneTree | ENSGT00440000033919 | |
| HOGENOM | HOG000162649 | |
| InParanoid | P40362 | |
| KO | K14553 | |
| OMA | RTRKCIH | |
| OrthoDB | EOG7JX3DQ | |
| BioCyc | YEAST:G3O-31528-MONOMER | |
| Reactome | [www.reactome.org/content/detail/R-SCE-6790901 R-SCE-6790901] [www.reactome.org/content/detail/R-SCE-6791226 R-SCE-6791226] | |
| PRO | PR:P40362 | |
| Proteomes | UP000002311 | |
| GO | GO:0005730 GO:0005654 GO:0034388 GO:0032040 GO:0000480 GO:0000447 GO:0000472 GO:0031167 | |
| Gene3D | 2.130.10.10 | |
| InterPro | IPR015943 IPR001680 IPR017986 | |
| Pfam | PF00400 | |
| SMART | SM00320 | |
| SUPFAM | SSF50978 | |
| PROSITE | PS50082 PS50294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0000292 |
RNA fragment catabolic process |
ECO:0000315 |
P |
RNA polymerase I produces pre-rRNA that is processed into several fragments, including the 5’-ETS (external transcribed spacer) and 7S pre-rRNA. The RNA exosome is a 3’ to 5’ exonuclease involved in the processing of 7S pre-rRNA into mature 5.8S rRNA and in the degradation of the 5’-ETS. The exosome requires protein cofactors that interact with the Mtr4 helicase for substrate specificity. One of these cofactors is Utp18. The N-terminus of Utp18 is required for binding with the arch domain of Mtr4, and subsequently for presentation of the 5’-ETS substrate to the RNA exosome. Figure 4C shows a northern blot where in lane 5, the N-terminus Utp18 S. cerevisiae mutant accumulates 5’-ETS. The wild type Utp18 strain showed no band for 5’ETS, showing it was degraded. Therefore, Utp18 is involved in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing (Go termGO:0000292). |
complete | |||||
|
part_of |
GO:0030686 |
90S preribosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034388 |
Pwp2p-containing subcomplex of 90S preribosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034388 |
Pwp2p-containing subcomplex of 90S preribosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032040 |
small-subunit processome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000480 |
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000472 |
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000447 |
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034388 |
Pwp2p-containing subcomplex of 90S preribosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000427904 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032040 |
small-subunit processome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000427904 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031167 |
rRNA methylation |
Reactome:R-SCE-6790936 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-SCE-6790936 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042254 |
ribosome biogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006364 |
rRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Thoms, M et al. (2015) The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins. Cell 162 1029-38 PubMed GONUTS page
- ↑ Grandi, P et al. (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol. Cell 10 105-15 PubMed GONUTS page
- ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
- ↑ Dosil, M & Bustelo, XR (2004) Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle. J. Biol. Chem. 279 37385-97 PubMed GONUTS page
- ↑ Pérez-Fernández, J et al. (2007) The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol. Cell. Biol. 27 5414-29 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Bernstein, KA et al. (2004) The small-subunit processome is a ribosome assembly intermediate. Eukaryotic Cell 3 1619-26 PubMed GONUTS page
- ↑ 7.0 7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
d
e
- GO:0000480 ! endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- GO:0000472 ! endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- GO:0000447 ! endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- Eukaryota
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