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YEAST:TRX2
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | TRX2 (synonyms: TRX1) | |
| Protein Name(s) | Thioredoxin-2
Thioredoxin II TR-II Thioredoxin-1 | |
| External Links | ||
| UniProt | P22803 | |
| EMBL | M59168 M62648 U40843 Z49133 Z72994 AY557817 BK006941 | |
| PIR | S15049 | |
| RefSeq | NP_011725.3 | |
| PDB | 2FA4 2HSY 3PIN 4DSS | |
| PDBsum | 2FA4 2HSY 3PIN 4DSS | |
| ProteinModelPortal | P22803 | |
| SMR | P22803 | |
| BioGrid | 33462 | |
| DIP | DIP-5552N | |
| IntAct | P22803 | |
| MINT | MINT-474704 | |
| STRING | 4932.YGR209C | |
| MaxQB | P22803 | |
| PaxDb | P22803 | |
| PeptideAtlas | P22803 | |
| EnsemblFungi | [example_ID YGR209C] | |
| GeneID | 853123 | |
| KEGG | sce:YGR209C | |
| SGD | S000003441 | |
| eggNOG | COG0526 | |
| GeneTree | ENSGT00530000063008 | |
| HOGENOM | HOG000292977 | |
| InParanoid | P22803 | |
| KO | K03671 | |
| OMA | CKMISPH | |
| OrthoDB | EOG71CFZN | |
| BioCyc | YEAST:G3O-30891-MONOMER | |
| Reactome | REACT_188484 REACT_189238 REACT_191152 REACT_238684 | |
| EvolutionaryTrace | P22803 | |
| NextBio | 973163 | |
| Proteomes | UP000002311 | |
| Genevestigator | P22803 | |
| GO | GO:0005829 GO:0000324 GO:0000139 GO:0005634 GO:0015036 GO:0015035 GO:0045454 GO:0009263 GO:0006888 GO:0006749 GO:0006662 GO:0080058 GO:0015031 GO:0006890 GO:0000103 GO:0042144 GO:0000011 | |
| Gene3D | 3.40.30.10 | |
| InterPro | IPR005746 IPR012336 IPR017937 IPR013766 | |
| PANTHER | PTHR10438 | |
| Pfam | PF00085 | |
| PIRSF | PIRSF000077 | |
| SUPFAM | SSF52833 | |
| TIGRFAMs | TIGR01068 | |
| PROSITE | PS00194 PS51352 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000004033 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080058 |
protein deglutathionylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:Q12324) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006749 |
glutathione metabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000006012 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080058 |
protein deglutathionylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000004033 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080058 |
protein deglutathionylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042144 |
vacuole fusion, non-autophagic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015036 |
disulfide oxidoreductase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0000011 |
vacuole inheritance |
ECO:0000315 |
P |
complete | ||||||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000324 |
fungal-type vacuole |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000103 |
sulfate assimilation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000004033 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000011 |
vacuole inheritance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000011 |
vacuole inheritance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006662 |
glycerol ether metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015035 |
protein disulfide oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009263 |
deoxyribonucleotide biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Dardalhon, M et al. () Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes. Free Radic. Biol. Med. 52 2254-65 PubMed GONUTS page
- ↑ Chandel, A et al. (2016) Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines. Mol. Biol. Cell 27 3913-3925 PubMed GONUTS page
- ↑ Morgan, B et al. (2013) Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nat. Chem. Biol. 9 119-25 PubMed GONUTS page
- ↑ 4.0 4.1 Greetham, D et al. (2010) Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae. BMC Biochem. 11 3 PubMed GONUTS page
- ↑ 5.0 5.1 Xu, Z et al. (1998) LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion. Cell 93 1125-34 PubMed GONUTS page
- ↑ Gan, ZR (1991) Yeast thioredoxin genes. J. Biol. Chem. 266 1692-6 PubMed GONUTS page
- ↑ 7.0 7.1 Spang, A & Schekman, R (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J. Cell Biol. 143 589-99 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Xu, Z & Wickner, W (1996) Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae. J. Cell Biol. 132 787-94 PubMed GONUTS page
- ↑ Muller, EG (1991) Thioredoxin deficiency in yeast prolongs S phase and shortens the G1 interval of the cell cycle. J. Biol. Chem. 266 9194-202 PubMed GONUTS page
- ↑ Xu, Z et al. (1997) A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance. J. Cell Biol. 136 299-306 PubMed GONUTS page
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