YEAST:TRM1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	TRM1
Protein Name(s)	tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial tRNA 2,2-dimethylguanosine-26 methyltransferase tRNA(guanine-26,N(2)-N(2)) methyltransferase tRNA(m(2,2)G26)dimethyltransferase
External Links
UniProt	P15565
EMBL	M17193 AF086825 AF086826 Z48758 BK006938
PIR	A28323
RefSeq	NP_010405.3
ProteinModelPortal	P15565
BioGrid	32176
DIP	DIP-5202N
IntAct	P15565
MINT	MINT-475232
iPTMnet	P15565
PRIDE	P15565
EnsemblFungi	YDR120C
GeneID	851698
KEGG	sce:YDR120C
EuPathDB	FungiDB:YDR120C
SGD	S000002527
GeneTree	ENSGT00530000063646
HOGENOM	HOG000177995
InParanoid	P15565
KO	K00555
OMA	VTCIKAW
OrthoDB	EOG092C2Z4E
BioCyc	MetaCyc:G3O-29720-MONOMER YEAST:G3O-29720-MONOMER
BRENDA	2.1.1.216
PRO	PR:P15565
Proteomes	UP000002311
GO	GO:0005739 GO:0005635 GO:0005637 GO:0004809 GO:0000049 GO:0030488 GO:0002940
Gene3D	3.40.50.150
InterPro	IPR029063 IPR002905
PANTHER	PTHR10631
Pfam	PF02005
SUPFAM	SSF53335
TIGRFAMs	TIGR00308
PROSITE	PS51626

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	PMID:2426253^[1]	ECO:0000315			F	Based on Figure 6, the TRM1 gene codes for the structural proteins that causes tRNA M(2,2) guanine- methyltransferase activity, as expressed in the deficient cells seen with the open circle plot in the E. coli cells that were targeted for TRM1 expression. S. Cerevisiae, ATCC 204508 / S288c	complete CACAO 12332
involved_in	GO:0030488	tRNA methylation	PMID:2426253^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:7599275^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:19602197^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:7599275^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:7599275^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	PMID:9801306^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	PMID:9801306^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000066877 UniProtKB:Q5AQM4	C	Seeded From UniProt	complete
enables	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000066877 PomBase:SPBC25D12.05 SGD:S000002527 UniProtKB:Q9NXH9	F	Seeded From UniProt	complete
involved_in	GO:0002940	tRNA N2-guanine methylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000066877 PomBase:SPBC25D12.05	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002905	F	Seeded From UniProt	complete
enables	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002905	F	Seeded From UniProt	complete
involved_in	GO:0008033	tRNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002905	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0000049	tRNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0820	F	Seeded From UniProt	complete
involved_in	GO:0008033	tRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0819	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0179	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ellis, SR et al. (1986) Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae. J. Biol. Chem. 261 9703-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Rose, AM et al. (1995) Location of N2,N2-dimethylguanosine-specific tRNA methyltransferase. Biochimie 77 45-53 PubMed GONUTS page
↑ Lai, TP et al. (2009) Mechanism and a peptide motif for targeting peripheral proteins to the yeast inner nuclear membrane. Traffic 10 1243-56 PubMed GONUTS page
↑ ^4.0 ^4.1 Liu, J et al. (1998) Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase. Nucleic Acids Res. 26 5102-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2426253-1] 1.0 ^1.1 Ellis, SR et al. (1986) Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae. J. Biol. Chem. 261 9703-9 PubMed GONUTS page

[PMID:7599275-2] 2.0 ^2.1 ^2.2 Rose, AM et al. (1995) Location of N2,N2-dimethylguanosine-specific tRNA methyltransferase. Biochimie 77 45-53 PubMed GONUTS page

[PMID:19602197-3] Lai, TP et al. (2009) Mechanism and a peptide motif for targeting peripheral proteins to the yeast inner nuclear membrane. Traffic 10 1243-56 PubMed GONUTS page

[PMID:9801306-4] 4.0 ^4.1 Liu, J et al. (1998) Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase. Nucleic Acids Res. 26 5102-8 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:TRM1

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