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YEAST:TOP3
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | TOP3 (synonyms: EDR1) | |
| Protein Name(s) | DNA topoisomerase 3
DNA topoisomerase III | |
| External Links | ||
| UniProt | P13099 | |
| EMBL | M24939 U19027 BK006945 | |
| PIR | A33169 | |
| RefSeq | NP_013335.1 | |
| ProteinModelPortal | P13099 | |
| SMR | P13099 | |
| BioGrid | 31503 | |
| DIP | DIP-2912N | |
| IntAct | P13099 | |
| MINT | MINT-442624 | |
| STRING | 4932.YLR234W | |
| MaxQB | P13099 | |
| PaxDb | P13099 | |
| PeptideAtlas | P13099 | |
| EnsemblFungi | [example_ID YLR234W] | |
| GeneID | 850935 | |
| KEGG | sce:YLR234W | |
| CYGD | YLR234w | |
| SGD | S000004224 | |
| eggNOG | COG0550 | |
| GeneTree | ENSGT00530000063430 | |
| HOGENOM | HOG000184377 | |
| InParanoid | P13099 | |
| KO | K03165 | |
| OMA | RIYPWER | |
| OrthoDB | EOG7Q8CWW | |
| BioCyc | YEAST:G3O-32345-MONOMER | |
| NextBio | 967378 | |
| PRO | PR:P13099 | |
| Proteomes | UP000002311 | |
| Genevestigator | P13099 | |
| GO | GO:0005634 GO:0031422 GO:0003677 GO:0003916 GO:0003917 GO:0006265 GO:0007064 GO:0007131 GO:0000018 GO:0007004 | |
| Gene3D | 1.10.290.10 1.10.460.10 3.40.50.140 | |
| InterPro | IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013826 IPR023405 IPR003602 IPR006171 | |
| PANTHER | PTHR11390 | |
| Pfam | PF01131 PF01751 | |
| PRINTS | PR00417 | |
| SMART | SM00437 SM00436 SM00493 | |
| SUPFAM | SSF56712 | |
| PROSITE | PS00396 PS50880 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0031422 |
RecQ helicase-Topo III complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
SGD:S000004802 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031422 |
RecQ helicase-Topo III complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007131 |
reciprocal meiotic recombination |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0007131 |
reciprocal meiotic recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007064 |
mitotic sister chromatid cohesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007004 |
telomere maintenance via telomerase |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000305 |
curator inference used in manual assertion |
GO:0003917 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000018 |
regulation of DNA recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0026015 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040268 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040268 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000380 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000380 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Chang, M et al. (2005) RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J. 24 2024-33 PubMed GONUTS page
- ↑ Mullen, JR et al. (2005) Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mol. Cell. Biol. 25 4476-87 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Bailis, AM et al. (1992) Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene. Mol. Cell. Biol. 12 4988-93 PubMed GONUTS page
- ↑ Lai, MS et al. (2007) Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion. EMBO Rep. 8 685-90 PubMed GONUTS page
- ↑ Kim, RA et al. (1995) Effects of yeast DNA topoisomerase III on telomere structure. Proc. Natl. Acad. Sci. U.S.A. 92 2667-71 PubMed GONUTS page
- ↑ 6.0 6.1 Cejka, P et al. (2012) Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes. Mol. Cell 47 886-96 PubMed GONUTS page
- ↑ 7.0 7.1 Kim, RA & Wang, JC (1992) Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase. J. Biol. Chem. 267 17178-85 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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