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YEAST:TOP1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | TOP1 (synonyms: MAK1) | |
| Protein Name(s) | DNA topoisomerase 1
DNA topoisomerase I Maintenance of killer protein 1 | |
| External Links | ||
| UniProt | P04786 | |
| EMBL | K03077 Z74748 BK006948 | |
| PIR | A23161 | |
| RefSeq | NP_014637.1 | |
| PDB | 1OIS | |
| PDBsum | 1OIS | |
| ProteinModelPortal | P04786 | |
| SMR | P04786 | |
| BioGrid | 34398 | |
| DIP | DIP-1705N | |
| IntAct | P04786 | |
| MINT | MINT-386768 | |
| ChEMBL | CHEMBL5948 | |
| iPTMnet | P04786 | |
| MaxQB | P04786 | |
| PRIDE | P04786 | |
| EnsemblFungi | YOL006C | |
| GeneID | 854156 | |
| KEGG | sce:YOL006C | |
| EuPathDB | FungiDB:YOL006C | |
| SGD | S000005366 | |
| GeneTree | ENSGT00390000016347 | |
| HOGENOM | HOG000105469 | |
| InParanoid | P04786 | |
| KO | K03163 | |
| OMA | VMDNHKE | |
| OrthoDB | EOG092C0N3X | |
| BioCyc | YEAST:G3O-33423-MONOMER | |
| Reactome | [www.reactome.org/content/detail/R-SCE-4615885 R-SCE-4615885] | |
| EvolutionaryTrace | P04786 | |
| PRO | PR:P04786 | |
| Proteomes | UP000002311 | |
| GO | GO:0005730 GO:0005654 GO:0005634 GO:0031298 GO:0003677 GO:0003917 GO:0006333 GO:0006338 GO:0000183 GO:0006271 GO:0006265 GO:0007076 GO:0007097 GO:0000019 GO:0006357 GO:0006368 | |
| CDD | cd00659 | |
| Gene3D | 1.10.10.41 1.10.132.10 2.170.11.10 3.90.15.10 | |
| InterPro | IPR011010 IPR013034 IPR001631 IPR018521 IPR025834 IPR014711 IPR014727 IPR013500 IPR008336 IPR013030 IPR013499 | |
| Pfam | PF14370 PF01028 PF02919 | |
| PRINTS | PR00416 | |
| SMART | SM00435 | |
| SUPFAM | SSF56349 SSF56741 | |
| PROSITE | PS00176 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045910 |
negative regulation of DNA recombination |
ECO:0000315 |
P |
Paper’s Protein Name: Top1. UniProt.’s Protein Name: DNA topoisomerase 1. Organism: Saccharomyces cerevisiae (“all strains derived from YPH45”). Notes: This paper actually implies that Top1’s effects on genome stability and DNA recombination had already been proven beforehand. Nevertheless, this paper provides evidence for the correlation as well, specifically in Figures 1A-B. In Figure 1A, wild type yeast has a DNA recombination rate of about 20*10^-8 for GTOP. However, Figure 1B shows that when the Top1 protein is mutated and knocked out, this rate is over 100*10^-8. It is important to note that these two charts are scaled very differently. Because recombination is elevated in Top1’s absence, it is implied that Top1 negatively regulates DNA recombination. |
complete | |||||
|
part_of |
GO:0031298 |
replication fork protection complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007097 |
nuclear migration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0007097 |
nuclear migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007076 |
mitotic chromosome condensation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0007076 |
mitotic chromosome condensation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006333 |
chromatin assembly or disassembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006271 |
DNA strand elongation involved in DNA replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000353 |
physical interaction evidence used in manual assertion |
SGD:S000003391 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000183 |
chromatin silencing at rDNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000019 |
regulation of mitotic recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031298 |
replication fork protection complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000033230 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004924 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000033230 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004924 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006260 |
DNA replication |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98788 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004924 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004924 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001631 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001631 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR008336 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001631 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lopez, CR et al. (2017) Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. Nucleic Acids Res. PubMed GONUTS page
- ↑ Gambus, A et al. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat. Cell Biol. 8 358-66 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Castaño, IB et al. (1996) Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae. Genes Dev. 10 2564-76 PubMed GONUTS page
- ↑ Brill, SJ & Sternglanz, R (1988) Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell 54 403-11 PubMed GONUTS page
- ↑ Choder, M (1991) A general topoisomerase I-dependent transcriptional repression in the stationary phase in yeast. Genes Dev. 5 2315-26 PubMed GONUTS page
- ↑ Garinther, WI & Schultz, MC (1997) Topoisomerase function during replication-independent chromatin assembly in yeast. Mol. Cell. Biol. 17 3520-6 PubMed GONUTS page
- ↑ Kim, RA & Wang, JC (1989) Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae. J. Mol. Biol. 208 257-67 PubMed GONUTS page
- ↑ 8.0 8.1 Thrash, C et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc. Natl. Acad. Sci. U.S.A. 82 4374-8 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Goto, T et al. (1984) The purification and characterization of DNA topoisomerases I and II of the yeast Saccharomyces cerevisiae. J. Biol. Chem. 259 10422-9 PubMed GONUTS page
- ↑ Edwards, TK et al. (2000) Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I. J. Biol. Chem. 275 36181-8 PubMed GONUTS page
- ↑ Smith, JS et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol. Cell. Biol. 19 3184-97 PubMed GONUTS page
- ↑ Christman, MF et al. (1988) Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II. Cell 55 413-25 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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