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YEAST:TOM40

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) TOM40 (synonyms: ISP42, MOM38)
Protein Name(s) Mitochondrial import receptor subunit TOM40

Mitochondrial import site protein ISP42 Translocase of outer membrane 40 kDa subunit

External Links
UniProt P23644
EMBL X56885
Z48755
AY693021
BK006946
PIR S12773
RefSeq NP_013930.1
ProteinModelPortal P23644
BioGrid 35381
DIP DIP-2540N
IntAct P23644
MINT MINT-527881
STRING 4932.YMR203W
TCDB 1.B.8.2.1
3.A.8.1.1
MaxQB P23644
PaxDb P23644
PeptideAtlas P23644
EnsemblFungi [example_ID YMR203W]
GeneID 855243
KEGG sce:YMR203W
CYGD YMR203w
SGD S000004816
eggNOG NOG275568
GeneTree ENSGT00390000003308
HOGENOM HOG000200591
InParanoid P23644
KO K11518
OMA GNQELLM
OrthoDB EOG7D865Z
BioCyc YEAST:G3O-32889-MONOMER
Reactome REACT_189012
NextBio 978801
Proteomes UP000002311
Genevestigator P23644
GO GO:0005829
GO:0005758
GO:0005741
GO:0005742
GO:0046930
GO:0015288
GO:0015266
GO:0006811
GO:0030150
Gene3D 2.40.160.10
InterPro IPR023614
IPR027246
IPR005686
Pfam PF01459
TIGRFAMs TIGR00989

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005741

mitochondrial outer membrane

PMID:16407407[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16823961[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:24769239[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:11914276[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14576278[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030150

protein import into mitochondrial matrix

PMID:15590639[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008320

protein transmembrane transporter activity

PMID:9774109[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005742

mitochondrial outer membrane translocase complex

PMID:9774667[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030150

protein import into mitochondrial matrix

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000085854
SGD:S000004816

P

Seeded From UniProt

complete

enables

GO:0008320

protein transmembrane transporter activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000085854
RGD:1303022
SGD:S000004816

F

Seeded From UniProt

complete

part_of

GO:0005742

mitochondrial outer membrane translocase complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000085854
RGD:1303022
RGD:1562006
SGD:S000004816
UniProtKB:O96008

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005686
InterPro:IPR027246
InterPro:IPR037930

C

Seeded From UniProt

complete

enables

GO:0008320

protein transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005686
InterPro:IPR037930

F

Seeded From UniProt

complete

involved_in

GO:0030150

protein import into mitochondrial matrix

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005686
InterPro:IPR037930

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027246

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-SCE-1252255

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

Reactome:R-SCE-1252262
Reactome:R-SCE-1252261
Reactome:R-SCE-1252259
Reactome:R-SCE-1252255

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

Reactome:R-SCE-8953627
Reactome:R-SCE-1252261
Reactome:R-SCE-1252255

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

enables

GO:0015288

porin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0626

F

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0046930

pore complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0626

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Zahedi, RP et al. (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol. Biol. Cell 17 1436-50 PubMed GONUTS page
  2. ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  3. ↑ Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page
  4. ↑ Kumar, A et al. (2002) Subcellular localization of the yeast proteome. Genes Dev. 16 707-19 PubMed GONUTS page
  5. ↑ Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
  6. ↑ Habib, SJ et al. (2005) Assembly of the TOB complex of mitochondria. J. Biol. Chem. 280 6434-40 PubMed GONUTS page
  7. ↑ Hill, K et al. (1998) Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment]. Nature 395 516-21 PubMed GONUTS page
  8. ↑ Dekker, PJ et al. (1998) Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol. Cell. Biol. 18 6515-24 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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