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YEAST:STT4

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) STT4
Protein Name(s) Phosphatidylinositol 4-kinase STT4

PI4-kinase PtdIns-4-kinase

External Links
UniProt P37297
EMBL D13717
U17247
U17243
BK006945
PIR S45530
RefSeq NP_013408.1
ProteinModelPortal P37297
BioGrid 31570
DIP DIP-1677N
IntAct P37297
MINT MINT-388790
STRING 4932.YLR305C
MaxQB P37297
PaxDb P37297
PeptideAtlas P37297
EnsemblFungi [example_ID YLR305C]
GeneID 851014
KEGG sce:YLR305C
CYGD YLR305c
SGD S000004296
eggNOG COG5032
GeneTree ENSGT00550000074798
HOGENOM HOG000179764
InParanoid P37297
KO K00888
OMA AFRGIFH
OrthoDB EOG7T4MTW
BioCyc YEAST:G3O-32393-MONOMER
YEAST:MONOMER3O-365
Reactome REACT_188954
REACT_188955
NextBio 967574
PRO PR:P37297
Proteomes UP000002311
Genevestigator P37297
GO GO:0005886
GO:0004430
GO:0005524
GO:0046854
GO:0048015
Gene3D 1.10.1070.11
1.25.40.70
InterPro IPR016024
IPR011009
IPR000403
IPR018936
IPR015433
IPR001263
PANTHER PTHR10048
Pfam PF00454
PF00613
SMART SM00145
SM00146
SUPFAM SSF48371
SSF56112
PROSITE PS00915
PS00916
PS50290
PS51545

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030866

cortical actin cytoskeleton organization

PMID:10930462[1]

ECO:0000315

P

Figure 4 - nonpermissive temp results in failure of proper cortical actin organization

complete
CACAO 9836

GO:0060237

regulation of fungal-type cell wall organization

PMID:10930462[1]

ECO:0000315

P

Figure 5 - KO results in cell lysis

complete
CACAO 9837

part_of

GO:0005739

mitochondrion

PMID:16823961[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14576278[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:22977244[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:22977244[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060237

regulation of fungal-type cell wall organization

PMID:10930462[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030866

cortical actin cytoskeleton organization

PMID:10930462[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:10930462[1]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000005211

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:9346907[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:19075114[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:12015967[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

PMID:8288577[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

PMID:9346907[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048015

phosphatidylinositol-mediated signaling

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000005673
RGD:620899
dictyBase:DDB_G0278727
dictyBase:DDB_G0283081

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015277
FB:FBgn0015278
FB:FBgn0015279
FB:FBgn0267350
MGI:MGI:2448506
PANTHER:PTN000005673
RGD:620916
RGD:620917
SGD:S000004230
SGD:S000004296
SGD:S000005211
UniProtKB:A0A1D8PDV7
UniProtKB:P32871

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000005673
PomBase:SPAC458.05
TAIR:locus:2164401
UniProtKB:P48736

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000006021
PomBase:SPBC577.06c
SGD:S000004296
TAIR:locus:2010202
UniProtKB:A0A1D8PTE0
UniProtKB:P42356

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000005673
RGD:621214
UniProtKB:O00443
UniProtKB:P42356
UniProtKB:P48736
WB:WBGene00000090
WB:WBGene00006932
WB:WBGene00009552
dictyBase:DDB_G0291093

C

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2448506
PANTHER:PTN000006021
RGD:621213
SGD:S000004296
TAIR:locus:2010202

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018936
InterPro:IPR036940

F

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015433

P

Seeded From UniProt

complete

involved_in

GO:0048015

phosphatidylinositol-mediated signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015433

P

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.67

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Audhya, A et al. (2000) Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Mol. Biol. Cell 11 2673-89 PubMed GONUTS page
  2. Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  3. Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
  4. 4.0 4.1 Wang, K et al. (2012) Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking. J. Biol. Chem. 287 37964-72 PubMed GONUTS page
  5. 5.0 5.1 Cutler, NS et al. (1997) STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. J. Biol. Chem. 272 27671-7 PubMed GONUTS page
  6. Baird, D et al. (2008) Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. J. Cell Biol. 183 1061-74 PubMed GONUTS page
  7. Audhya, A & Emr, SD (2002) Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev. Cell 2 593-605 PubMed GONUTS page
  8. Yoshida, S et al. (1994) A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae. J. Biol. Chem. 269 1166-72 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page