YEAST:SKM1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	SKM1
Protein Name(s)	Serine/threonine-protein kinase SKM1 Protein kinase 75490 D
External Links
UniProt	Q12469
EMBL	X69322 Z48149 Z74855 AY693219 BK006948
PIR	S51884
RefSeq	NP_014528.1
ProteinModelPortal	Q12469
SMR	Q12469
BioGrid	34287
DIP	DIP-4217N
IntAct	Q12469
MINT	MINT-546388
MaxQB	Q12469
PaxDb	Q12469
EnsemblFungi	[example_ID YOL113W]
GeneID	854036
KEGG	sce:YOL113W
CYGD	YOL113w
SGD	S000005473
eggNOG	COG0515
GeneTree	ENSGT00680000099731
HOGENOM	HOG000234202
InParanoid	Q12469
KO	K08286
OMA	WYDASAT
OrthoDB	EOG708W7W
BioCyc	YEAST:G3O-33510-MONOMER
BRENDA	2.7.11.1
NextBio	975595
Proteomes	UP000002311
Genevestigator	Q12469
GO	GO:0005634 GO:0005886 GO:0005524 GO:0004674 GO:0000920 GO:0010629 GO:0006468 GO:0035376
Gene3D	2.30.29.30 3.90.810.10
InterPro	IPR000095 IPR011009 IPR001849 IPR011993 IPR000719 IPR002290 IPR008271
Pfam	PF00786 PF00169 PF00069
SMART	SM00285 SM00233 SM00220
SUPFAM	SSF56112
PROSITE	PS50108 PS50003 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0004672	protein kinase activity	PMID:16319894^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16319894^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990872	negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter	PMID:19793923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035376	sterol import	PMID:19793923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:19793923^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003130	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:19793923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9044278^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48562 UniProtKB:Q03497	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15023338^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19793923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19793923^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9044278^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48562 UniProtKB:Q03497	F	Seeded From UniProt	complete
involved_in	GO:0000920	septum digestion after cytokinesis	PMID:9044278^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F	Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267698 PANTHER:PTN002390586 UniProtKB:A0A0B4KGS4 UniProtKB:Q13153 UniProtKB:Q13177 WB:WBGene00003144	F	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339975 PANTHER:PTN002390586	P	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P	Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002390586 WB:WBGene00003144 WB:WBGene00003911	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033923	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Lin, M et al. (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol. Biol. Cell 20 4826-37 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Martín, H et al. (1997) Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase. Mol. Microbiol. 23 431-44 PubMed GONUTS page
↑ Yu, JW et al. (2004) Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol. Cell 13 677-88 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16319894-1] 1.0 ^1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page

[PMID:19793923-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Lin, M et al. (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol. Biol. Cell 20 4826-37 PubMed GONUTS page

[PMID:9044278-3] 3.0 ^3.1 ^3.2 Martín, H et al. (1997) Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase. Mol. Microbiol. 23 431-44 PubMed GONUTS page

[PMID:15023338-4] Yu, JW et al. (2004) Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol. Cell 13 677-88 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:SKM1

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