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YEAST:SEN2

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) SEN2
Protein Name(s) tRNA-splicing endonuclease subunit SEN2

Splicing endonuclease protein 2 tRNA-intron endonuclease SEN2

External Links
UniProt P16658
EMBL M32336
Z73277
U53876
BK006945
PIR A38862
RefSeq NP_013206.1
ProteinModelPortal P16658
SMR P16658
BioGrid 31378
DIP DIP-4821N
IntAct P16658
MINT MINT-546309
STRING 4932.YLR105C
MaxQB P16658
PaxDb P16658
EnsemblFungi [example_ID YLR105C]
GeneID 850795
KEGG sce:YLR105C
CYGD YLR105c
SGD S000004095
eggNOG COG1676
GeneTree ENSGT00390000013266
HOGENOM HOG000159660
InParanoid P16658
KO K15322
OMA SPACLAH
OrthoDB EOG7SXWFH
BioCyc MetaCyc:MONOMER-16148
YEAST:G3O-32253-MONOMER
NextBio 967008
PRO PR:P16658
Proteomes UP000002311
Genevestigator P16658
GO GO:0012505
GO:0005741
GO:0000214
GO:0016829
GO:0003676
GO:0000213
GO:0090501
GO:0090502
GO:0000379
Gene3D 3.40.1350.10
InterPro IPR011856
IPR006677
IPR006676
IPR016589
Pfam PF01974
PIRSF PIRSF011789
SUPFAM SSF53032
TIGRFAMs TIGR00324

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000213

tRNA-intron endonuclease activity

PMID:17352735[1]

ECO:0000315

F

Fig 2 shows sen2 gave least amount of pre-tRNA, i.e. shows the tRNA splicing function of the gene.

complete
CACAO 4371

part_of

GO:0005739

mitochondrion

PMID:16823961[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:16407407[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0098787

mRNA cleavage involved in mRNA processing

PMID:25971974[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(SGD:S000003745)

Seeded From UniProt

complete

enables

GO:0000213

tRNA-intron endonuclease activity

PMID:17352735[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:12925762[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:12925762[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000379

tRNA-type intron splice site recognition and cleavage

PMID:2182322[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000379

tRNA-type intron splice site recognition and cleavage

PMID:9200603[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000214

tRNA-intron endonuclease complex

PMID:9200603[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000213

tRNA-intron endonuclease activity

PMID:2182322[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000213

tRNA-intron endonuclease activity

PMID:9200603[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000379

tRNA-type intron splice site recognition and cleavage

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000477043
SGD:S000004095

P

Seeded From UniProt

complete

part_of

GO:0000214

tRNA-intron endonuclease complex

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000477043
SGD:S000004095

C

Seeded From UniProt

complete

enables

GO:0000213

tRNA-intron endonuclease activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000477043
SGD:S000004095

F

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0000213

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000213

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000213

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000213

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000213

P

Seeded From UniProt

complete

enables

GO:0000213

tRNA-intron endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006676
InterPro:IPR006677
InterPro:IPR016589
InterPro:IPR036167

F

Seeded From UniProt

complete

part_of

GO:0000214

tRNA-intron endonuclease complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016589

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011856

F

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011856

F

Seeded From UniProt

complete

involved_in

GO:0006388

tRNA splicing, via endonucleolytic cleavage and ligation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006676
InterPro:IPR006677
InterPro:IPR016589
InterPro:IPR036167

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

involved_in

GO:0008033

tRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0819

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0012505

endomembrane system

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0147

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Yoshihisa, T et al. (2007) Cytoplasmic splicing of tRNA in Saccharomyces cerevisiae. Genes Cells 12 285-97 PubMed GONUTS page
  2. ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  3. ↑ Zahedi, RP et al. (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol. Biol. Cell 17 1436-50 PubMed GONUTS page
  4. ↑ Tsuboi, T et al. (2015) The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localized CBP1 mRNA. J. Biol. Chem. 290 16021-30 PubMed GONUTS page
  5. ↑ 5.0 5.1 Yoshihisa, T et al. (2003) Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria. Mol. Biol. Cell 14 3266-79 PubMed GONUTS page
  6. ↑ 6.0 6.1 Ho, CK et al. (1990) Accumulation of pre-tRNA splicing '2/3' intermediates in a Saccharomyces cerevisiae mutant. EMBO J. 9 1245-52 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Trotta, CR et al. (1997) The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases. Cell 89 849-58 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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