YEAST:SAK1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	SAK1 (synonyms: PAK1)
Protein Name(s)	SNF1-activating kinase 1
External Links
UniProt	P38990
EMBL	U18916 U13398 BK006939
PIR	S50632
RefSeq	NP_011055.3
ProteinModelPortal	P38990
SMR	P38990
BioGrid	36873
DIP	DIP-5407N
IntAct	P38990
MINT	MINT-520035
STRING	4932.YER129W
MaxQB	P38990
PaxDb	P38990
PeptideAtlas	P38990
EnsemblFungi	[example_ID YER129W]
GeneID	856866
KEGG	sce:YER129W
CYGD	YER129w
SGD	S000000931
eggNOG	COG0515
GeneTree	ENSGT00530000063214
HOGENOM	HOG000115426
InParanoid	P38990
KO	K07359
OMA	TNRISLT
OrthoDB	EOG76DV1W
BioCyc	YEAST:G3O-30292-MONOMER
BRENDA	2.7.11.1
Reactome	REACT_253424
NextBio	983228
PRO	PR:P38990
Proteomes	UP000002311
Genevestigator	P38990
GO	GO:0005737 GO:0005524 GO:0004674 GO:0006261 GO:0006006 GO:0006468 GO:0007124
InterPro	IPR020636 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24347
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007124	pseudohyphal growth	PMID:19880754^[1]	ECO:0000315			P		Figure 1 shows a lack of pseudalhyphal formation in the sak1 mutants compared to the wild-type.	complete CACAO 4800
part_of	GO:0005829	cytosol	PMID:26928762^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16319894^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14562095^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:16319894^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:27524664^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P06782)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:27524664^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P06782)	Seeded From UniProt	complete
involved_in	GO:0005979	regulation of glycogen biosynthetic process	PMID:15340085^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900180	regulation of protein localization to nucleus	PMID:15340085^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q04739) happens_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0007124	pseudohyphal growth	PMID:19880754^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12847291^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001531 SGD:S000003147	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16201971^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12748292^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12847291^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16201971^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12748292^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9341678^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006261	DNA-dependent DNA replication	PMID:9341678^[10]	ECO:0000316	genetic interaction evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16201971^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12748292^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12847291^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P06782)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16201971^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P06782)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12748292^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P06782)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22289182^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Orlova, M et al. (2010) Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiae. Eukaryotic Cell 9 208-14 PubMed GONUTS page
↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
↑ ^3.0 ^3.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
↑ ^5.0 ^5.1 McCartney, RR et al. (2016) Activation and inhibition of Snf1 kinase activity by phosphorylation within the activation loop. Biochim. Biophys. Acta 1864 1518-28 PubMed GONUTS page
↑ ^6.0 ^6.1 Hedbacker, K et al. (2004) Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase. Mol. Cell. Biol. 24 8255-63 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hong, SP et al. (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. U.S.A. 100 8839-43 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Elbing, K et al. (2006) Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem. J. 393 797-805 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Nath, N et al. (2003) Yeast Pak1 kinase associates with and activates Snf1. Mol. Cell. Biol. 23 3909-17 PubMed GONUTS page
↑ ^10.0 ^10.1 Hovland, PG et al. (1997) Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations. Mol. Gen. Genet. 256 45-53 PubMed GONUTS page
↑ Kettner, K et al. (2012) Saccharomyces cerevisiae gene YMR291W/TDA1 mediates the in vivo phosphorylation of hexokinase isoenzyme 2 at serine-15. FEBS Lett. 586 455-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19880754-1] 1.0 ^1.1 Orlova, M et al. (2010) Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiae. Eukaryotic Cell 9 208-14 PubMed GONUTS page

[PMID:26928762-2] Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page

[PMID:16319894-3] 3.0 ^3.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page

[PMID:14562095-4] Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page

[PMID:27524664-5] 5.0 ^5.1 McCartney, RR et al. (2016) Activation and inhibition of Snf1 kinase activity by phosphorylation within the activation loop. Biochim. Biophys. Acta 1864 1518-28 PubMed GONUTS page

[PMID:15340085-6] 6.0 ^6.1 Hedbacker, K et al. (2004) Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase. Mol. Cell. Biol. 24 8255-63 PubMed GONUTS page

[PMID:12847291-7] 7.0 ^7.1 ^7.2 Hong, SP et al. (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. U.S.A. 100 8839-43 PubMed GONUTS page

[PMID:16201971-8] 8.0 ^8.1 ^8.2 ^8.3 Elbing, K et al. (2006) Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem. J. 393 797-805 PubMed GONUTS page

[PMID:12748292-9] 9.0 ^9.1 ^9.2 ^9.3 Nath, N et al. (2003) Yeast Pak1 kinase associates with and activates Snf1. Mol. Cell. Biol. 23 3909-17 PubMed GONUTS page

[PMID:9341678-10] 10.0 ^10.1 Hovland, PG et al. (1997) Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations. Mol. Gen. Genet. 256 45-53 PubMed GONUTS page

[PMID:22289182-11] Kettner, K et al. (2012) Saccharomyces cerevisiae gene YMR291W/TDA1 mediates the in vivo phosphorylation of hexokinase isoenzyme 2 at serine-15. FEBS Lett. 586 455-8 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:SAK1

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