YEAST:RT107

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	RTT107 (synonyms: ESC4)
Protein Name(s)	Regulator of Ty1 transposition protein 107 Establishes silent chromatin protein 4
External Links
UniProt	P38850
EMBL	U10397 BK006934
PIR	S46755
RefSeq	NP_012024.1
PDB	3T7I 3T7J 3T7K
PDBsum	3T7I 3T7J 3T7K
ProteinModelPortal	P38850
SMR	P38850
BioGrid	36588
DIP	DIP-6297N
IntAct	P38850
MINT	MINT-702893
STRING	4932.YHR154W
MaxQB	P38850
PaxDb	P38850
PeptideAtlas	P38850
EnsemblFungi	[example_ID YHR154W]
GeneID	856559
KEGG	sce:YHR154W
CYGD	YHR154w
SGD	S000001197
eggNOG	NOG248673
InParanoid	P38850
OMA	RINTIFA
OrthoDB	EOG769ZTW
BioCyc	YEAST:G3O-31189-MONOMER
NextBio	982381
Proteomes	UP000002311
Genevestigator	P38850
GO	GO:0035361 GO:0005634 GO:0006302 GO:0010526
Gene3D	3.40.50.10190
InterPro	IPR001357
Pfam	PF00533
SMART	SM00292
SUPFAM	SSF52113
PROSITE	PS50172

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0071944	cell periphery	PMID:26928762^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14562095^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22842922^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1903775	regulation of DNA double-strand break processing	PMID:26490958^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000001	regulation of DNA damage checkpoint	PMID:26490958^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990683	DNA double-strand break attachment to nuclear envelope	PMID:27056668^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035361	Cul8-RING ubiquitin ligase complex	PMID:20139071^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010526	negative regulation of transposition, RNA-mediated	PMID:11779788^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:14988729^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:2000001	regulation of DNA damage checkpoint	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001413784 SGD:S000001197	P	Seeded From UniProt	complete
involved_in	GO:1990683	DNA double-strand break attachment to nuclear envelope	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001413784 SGD:S000001197	P	Seeded From UniProt	complete
part_of	GO:0035361	Cul8-RING ubiquitin ligase complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001413784 SGD:S000001197	C	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001413784 SGD:S000001197	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
↑ Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page
↑ ^4.0 ^4.1 Dibitetto, D et al. (2016) Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks. Nucleic Acids Res. 44 669-82 PubMed GONUTS page
↑ Horigome, C et al. (2016) PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes Dev. 30 931-45 PubMed GONUTS page
↑ Mimura, S et al. (2010) Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. J. Biol. Chem. 285 9858-67 PubMed GONUTS page
↑ Scholes, DT et al. (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159 1449-65 PubMed GONUTS page
↑ Rouse, J (2004) Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J. 23 1188-97 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26928762-1] Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page

[PMID:14562095-2] Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page

[PMID:22842922-3] Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page

[PMID:26490958-4] 4.0 ^4.1 Dibitetto, D et al. (2016) Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks. Nucleic Acids Res. 44 669-82 PubMed GONUTS page

[PMID:27056668-5] Horigome, C et al. (2016) PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes Dev. 30 931-45 PubMed GONUTS page

[PMID:20139071-6] Mimura, S et al. (2010) Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. J. Biol. Chem. 285 9858-67 PubMed GONUTS page

[PMID:11779788-7] Scholes, DT et al. (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159 1449-65 PubMed GONUTS page

[PMID:14988729-8] Rouse, J (2004) Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J. 23 1188-97 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:RT107

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