YEAST:RNA1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	RNA1
Protein Name(s)	Ran GTPase-activating protein 1 Protein involved in RNA production/processing
External Links
UniProt	P11745
EMBL	M27143 M27142 X17376 Z49939 X57160 BK006946
PIR	A32492
RefSeq	NP_013962.1
ProteinModelPortal	P11745
SMR	P11745
BioGrid	35413
DIP	DIP-2509N
IntAct	P11745
MINT	MINT-558123
iPTMnet	P11745
MaxQB	P11745
PeptideAtlas	P11745
EnsemblFungi	[example_ID YMR235C]
GeneID	855275
KEGG	sce:YMR235C
EuPathDB	FungiDB:YMR235C
SGD	S000004848
GeneTree	ENSGT00440000039203
HOGENOM	HOG000195026
InParanoid	P11745
KO	K14319
OMA	DLQDNAF
OrthoDB	EOG71ZPB0
BioCyc	YEAST:G3O-32916-MONOMER
NextBio	978897
PRO	PR:P11745
Proteomes	UP000002311
GO	GO:0000781 GO:0005829 GO:0005634 GO:0005096 GO:0006348 GO:0043547 GO:0006606 GO:0000054 GO:0006404 GO:0006407 GO:0006409
Gene3D	3.80.10.10
InterPro	IPR032675 IPR027038
PANTHER	PTHR24113

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	PMID:2116418^[1]	ECO:0000314			C	Fig. 7 A shows the fractionation of endogenous levels of RNA1 protein as detected by an anti-peptide serum. The cytoplasm-enriched fraction (lanes 3 and 11) contain antigen, but there is no antigen detected in the purified nuclear fraction (lanes 1 and 10).	complete CACAO 11788
involved_in	GO:0006606	protein import into nucleus	PMID:7657689^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006409	tRNA export from nucleus	PMID:22008473^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q12453	P	Seeded From UniProt	complete
involved_in	GO:0006409	tRNA export from nucleus	PMID:22008473^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006407	rRNA export from nucleus	PMID:11739405^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006404	RNA import into nucleus	PMID:16040803^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006348	chromatin silencing at telomere	PMID:17904525^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:2116418^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8755533^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8755533^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:7657689^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:9305944^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000054	ribosomal subunit export from nucleus	PMID:11739405^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0006348	C	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hopper, AK et al. (1990) The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus. J. Cell Biol. 111 309-21 PubMed GONUTS page
↑ ^2.0 ^2.1 Corbett, AH et al. (1995) Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J. Cell Biol. 130 1017-26 PubMed GONUTS page
↑ ^3.0 ^3.1 McGuire, AT & Mangroo, D (2012) Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex. Traffic 13 234-56 PubMed GONUTS page
↑ ^4.0 ^4.1 Gleizes, PE et al. (2001) Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex. J. Cell Biol. 155 923-36 PubMed GONUTS page
↑ Shaheen, HH & Hopper, AK (2005) Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 102 11290-5 PubMed GONUTS page
↑ Hayashi, N et al. (2007) Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 363 788-94 PubMed GONUTS page
↑ ^7.0 ^7.1 Traglia, HM et al. (1996) Nucleus-associated pools of Rna1p, the Saccharomyces cerevisiae Ran/TC4 GTPse activating protein involved in nucleus/cytosol transit. Proc. Natl. Acad. Sci. U.S.A. 93 7667-72 PubMed GONUTS page
↑ Haberland, J et al. (1997) The acidic C-terminal domain of rna1p is required for the binding of Ran.GTP and for RanGAP activity. J. Biol. Chem. 272 24717-26 PubMed GONUTS page

[PMID:2116418-1] 1.0 ^1.1 Hopper, AK et al. (1990) The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus. J. Cell Biol. 111 309-21 PubMed GONUTS page

[PMID:7657689-2] 2.0 ^2.1 Corbett, AH et al. (1995) Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J. Cell Biol. 130 1017-26 PubMed GONUTS page

[PMID:22008473-3] 3.0 ^3.1 McGuire, AT & Mangroo, D (2012) Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex. Traffic 13 234-56 PubMed GONUTS page

[PMID:11739405-4] 4.0 ^4.1 Gleizes, PE et al. (2001) Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex. J. Cell Biol. 155 923-36 PubMed GONUTS page

[PMID:16040803-5] Shaheen, HH & Hopper, AK (2005) Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 102 11290-5 PubMed GONUTS page

[PMID:17904525-6] Hayashi, N et al. (2007) Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 363 788-94 PubMed GONUTS page

[PMID:8755533-7] 7.0 ^7.1 Traglia, HM et al. (1996) Nucleus-associated pools of Rna1p, the Saccharomyces cerevisiae Ran/TC4 GTPse activating protein involved in nucleus/cytosol transit. Proc. Natl. Acad. Sci. U.S.A. 93 7667-72 PubMed GONUTS page

[PMID:9305944-8] Haberland, J et al. (1997) The acidic C-terminal domain of rna1p is required for the binding of Ran.GTP and for RanGAP activity. J. Biol. Chem. 272 24717-26 PubMed GONUTS page

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YEAST:RNA1

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