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YEAST:PP4R3
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | PSY2 | |
| Protein Name(s) | Serine/threonine-protein phosphatase 4 regulatory subunit 3
PP4R3 | |
| External Links | ||
| UniProt | P40164 | |
| EMBL | X78898 Z71477 BK006947 | |
| PIR | S50730 | |
| RefSeq | NP_014198.1 | |
| ProteinModelPortal | P40164 | |
| SMR | P40164 | |
| BioGrid | 35633 | |
| DIP | DIP-1513N | |
| IntAct | P40164 | |
| MINT | MINT-384732 | |
| MaxQB | P40164 | |
| PeptideAtlas | P40164 | |
| EnsemblFungi | YNL201C | |
| GeneID | 855520 | |
| KEGG | sce:YNL201C | |
| EuPathDB | FungiDB:YNL201C | |
| SGD | S000005145 | |
| GeneTree | ENSGT00390000018199 | |
| HOGENOM | HOG000115652 | |
| InParanoid | P40164 | |
| KO | K17491 | |
| OMA | YFKAFYS | |
| OrthoDB | EOG72VHFD | |
| BioCyc | YEAST:G3O-33210-MONOMER | |
| PRO | PR:P40164 | |
| Proteomes | UP000002311 | |
| GO | GO:0005634 GO:0030289 GO:0008601 GO:0006974 GO:2000002 GO:1902660 GO:2001034 GO:0006470 GO:0034047 GO:0072462 | |
| InterPro | IPR016024 IPR006887 IPR011993 | |
| Pfam | PF04802 | |
| SUPFAM | SSF48371 SSF50729 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
GFP tagged Psy2 was found to localize strongly in the nucleus (Figure 6C). |
complete | |||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001034 |
positive regulation of double-strand break repair via nonhomologous end joining |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000002 |
negative regulation of DNA damage checkpoint |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000002 |
negative regulation of DNA damage checkpoint |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902660 |
negative regulation of glucose mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072462 |
signal transduction involved in meiotic recombination checkpoint |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030289 |
protein phosphatase 4 complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030289 |
protein phosphatase 4 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030289 |
protein phosphatase 4 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019888 |
protein phosphatase regulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P22216) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001176 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0000794 |
condensed nuclear chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043666 |
regulation of phosphoprotein phosphatase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0019888 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Oler, AJ & Cairns, BR (2012) PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression. EMBO J. 31 1440-52 PubMed GONUTS page
- ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
- ↑ Omidi, K et al. (2014) Phosphatase complex Pph3/Psy2 is involved in regulation of efficient non-homologous end-joining pathway in the yeast Saccharomyces cerevisiae. PLoS ONE 9 e87248 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 O'Neill, BM et al. (2007) Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc. Natl. Acad. Sci. U.S.A. 104 9290-5 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Keogh, MC et al. (2006) A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439 497-501 PubMed GONUTS page
- ↑ Ma, H et al. (2014) Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression. Mol. Cell. Biol. 34 452-63 PubMed GONUTS page
- ↑ 7.0 7.1 Falk, JE et al. (2010) A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination. Dev. Cell 19 599-611 PubMed GONUTS page
- ↑ O'Neill, BM et al. (2004) Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Res. 32 6519-30 PubMed GONUTS page
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