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YEAST:PIK1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) PIK1
Protein Name(s) Phosphatidylinositol 4-kinase PIK1

PI4-kinase PtdIns-4-kinase

External Links
UniProt P39104
EMBL X76058
L20220
X92494
Z71543
BK006947
PIR A49335
RefSeq NP_014132.1
PDB 2JU0
PDBsum 2JU0
ProteinModelPortal P39104
SMR P39104
BioGrid 35573
DIP DIP-6770N
IntAct P39104
MINT MINT-622692
STRING 4932.YNL267W
MaxQB P39104
PaxDb P39104
PeptideAtlas P39104
EnsemblFungi [example_ID YNL267W]
GeneID 855454
KEGG sce:YNL267W
CYGD YNL267w
SGD S000005211
eggNOG COG5032
GeneTree ENSGT00550000074892
HOGENOM HOG000248748
InParanoid P39104
KO K00888
OMA YTRLYDQ
OrthoDB EOG7T4MTW
BioCyc YEAST:YNL267W-MONOMER
Reactome REACT_188955
EvolutionaryTrace P39104
NextBio 979370
PRO PR:P39104
Proteomes UP000002311
Genevestigator P39104
GO GO:0005634
GO:0005802
GO:0004430
GO:0005524
GO:0006661
GO:0046854
GO:0048015
Gene3D 1.10.1070.11
1.25.40.70
InterPro IPR016024
IPR011009
IPR027003
IPR021601
IPR000403
IPR018936
IPR015433
IPR001263
PANTHER PTHR10048
PTHR10048:SF22
Pfam PF00454
PF00613
PF11522
SMART SM00146
SUPFAM SSF48371
SSF56112
PROSITE PS00915
PS00916
PS50290
PS51545

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046854

phosphatidylinositol phosphorylation

PMID:10930462[1]

ECO:0000315

P

Figure 3A - nonpermissive temp results in decreased phosphorylated phosphotidylinositols

complete
CACAO 9832

GO:0050714

positive regulation of protein secretion

PMID:10930462[1]

ECO:0000315

P

Figure 6 - KO results in retention of proteins normally secreted from the cell.

complete
CACAO 9833

GO:0042998

positive regulation of Golgi to plasma membrane protein transport

PMID:10930462[1]

ECO:0000315

P

Figure 7 - KO results in failure of normal protein trafficking to vacuoles and PM

complete
CACAO 9834

GO:0006897

endocytosis

PMID:10930462[1]

ECO:0000315

P

Figure 7 - KO results in failure to endocytose and degrade certain proteins

complete
CACAO 9835

involved_in

GO:0006897

endocytosis

PMID:10930462[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042998

positive regulation of Golgi to plasma membrane protein transport

PMID:10930462[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050714

positive regulation of protein secretion

PMID:10930462[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:10930462[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:10587649[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:8248783[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:8194527[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

PMID:16365163[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

PMID:10587649[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10587649[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16365163[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8194527[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

PMID:10587649[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

PMID:8194527[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

PMID:8248783[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048015

phosphatidylinositol-mediated signaling

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000005673
RGD:620899
dictyBase:DDB_G0278727
dictyBase:DDB_G0283081

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015277
FB:FBgn0015278
FB:FBgn0015279
FB:FBgn0267350
MGI:MGI:2448506
PANTHER:PTN000005673
RGD:620916
RGD:620917
SGD:S000004230
SGD:S000004296
SGD:S000005211
UniProtKB:A0A1D8PDV7
UniProtKB:P32871

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000005673
PomBase:SPAC458.05
TAIR:locus:2164401
UniProtKB:P48736

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000005673
RGD:621214
UniProtKB:O00443
UniProtKB:P42356
UniProtKB:P48736
WB:WBGene00000090
WB:WBGene00006932
WB:WBGene00009552
dictyBase:DDB_G0291093

C

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000005893
RGD:621214
SGD:S000005211
TAIR:locus:2164401
UniProtKB:Q57WD8
UniProtKB:Q580E2
UniProtKB:Q8I406
UniProtKB:Q9UBF8

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018936
InterPro:IPR036940

F

Seeded From UniProt

complete

enables

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021601

F

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015433

P

Seeded From UniProt

complete

involved_in

GO:0048015

phosphatidylinositol-mediated signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015433

P

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.67

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Audhya, A et al. (2000) Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Mol. Biol. Cell 11 2673-89 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Walch-Solimena, C & Novick, P (1999) The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi. Nat. Cell Biol. 1 523-5 PubMed GONUTS page
  3. ↑ 3.0 3.1 Flanagan, CA et al. (1993) Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science 262 1444-8 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Garcia-Bustos, JF et al. (1994) PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus. EMBO J. 13 2352-61 PubMed GONUTS page
  5. ↑ 5.0 5.1 Strahl, T et al. (2005) Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus. J. Cell Biol. 171 967-79 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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