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YEAST:PEP7

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) PEP7 (synonyms: VAC1, VPL21, VPS19, VPT19)
Protein Name(s) Vacuolar segregation protein PEP7

Carboxypeptidase Y-deficient protein 7 Protein VAC1 Vacuolar protein sorting-associated protein 19 Vacuolar protein-targeting protein 19

External Links
UniProt P32609
EMBL M80596
U22070
U32517
BK006938
PIR S59811
RefSeq NP_010610.3
ProteinModelPortal P32609
SMR P32609
BioGrid 32381
DIP DIP-5240N
IntAct P32609
MINT MINT-541674
STRING 4932.YDR323C
MaxQB P32609
PaxDb P32609
EnsemblFungi [example_ID YDR323C]
GeneID 851923
KEGG sce:YDR323C
CYGD YDR323c
SGD S000002731
eggNOG NOG257999
HOGENOM HOG000001058
InParanoid P32609
OMA VCDDPNG
OrthoDB EOG7VB2QK
BioCyc YEAST:G3O-29880-MONOMER
NextBio 969971
Proteomes UP000002311
Genevestigator P32609
GO GO:0005737
GO:0010009
GO:0005774
GO:0046872
GO:0032266
GO:0006895
GO:0006896
GO:0000011
GO:0006904
GO:0006906
Gene3D 3.30.40.10
InterPro IPR007087
IPR015880
IPR000306
IPR017455
IPR011011
IPR013083
Pfam PF01363
SMART SM00064
SM00355
SUPFAM SSF57903
PROSITE PS50178
PS00028

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005737

cytoplasm

PMID:22842922[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22842922[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0032266

phosphatidylinositol-3-phosphate binding

PMID:9702203[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0010009

cytoplasmic side of endosome membrane

PMID:9168472[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006906

vesicle fusion

PMID:9168472[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006904

vesicle docking involved in exocytosis

PMID:9168472[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006896

Golgi to vacuole transport

PMID:10021387[4]

ECO:0000353

physical interaction evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006896

Golgi to vacuole transport

PMID:10021387[4]

ECO:0000316

genetic interaction evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

involved_in

GO:0006895

Golgi to endosome transport

PMID:9335586[5]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003063

P

Seeded From UniProt

complete

involved_in

GO:0006895

Golgi to endosome transport

PMID:9168472[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9168472[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000011

vacuole inheritance

PMID:1493335[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0006895

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0006895

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000306

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005773

vacuole

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0926

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page
  2. Burd, CG & Emr, SD (1998) Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Mol. Cell 2 157-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Webb, GC et al. (1997) Pep7p provides a novel protein that functions in vesicle-mediated transport between the yeast Golgi and endosome. Mol. Biol. Cell 8 871-95 PubMed GONUTS page
  4. 4.0 4.1 Peterson, MR et al. (1999) Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Curr. Biol. 9 159-62 PubMed GONUTS page
  5. Webb, GC et al. (1997) Genetic interactions between a pep7 mutation and the PEP12 and VPS45 genes: evidence for a novel SNARE component in transport between the Saccharomyces cerevisiae Golgi complex and endosome. Genetics 147 467-78 PubMed GONUTS page
  6. Raymond, CK et al. (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol. Biol. Cell 3 1389-402 PubMed GONUTS page