YEAST:PDR1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	PDR1 (synonyms: AMY1, ANT1, BOR2, CYH3, NRA2, SMR2, TIL1, TPE1, TPE3)
Protein Name(s)	Transcription factor PDR1 Pleiotropic drug resistance protein 1
External Links
UniProt	P12383
EMBL	J03487 S58126 Z72535 BK006941
PIR	S64015
RefSeq	NP_011502.1
ProteinModelPortal	P12383
BioGrid	33233
DIP	DIP-978N
IntAct	P12383
MINT	MINT-562805
STRING	4932.YGL013C
MaxQB	P12383
PaxDb	P12383
PeptideAtlas	P12383
EnsemblFungi	[example_ID YGL013C]
GeneID	852871
KEGG	sce:YGL013C
SGD	S000002981
eggNOG	NOG87502
GeneTree	ENSGT00530000069211
HOGENOM	HOG000115482
InParanoid	P12383
OMA	RRNLWWK
OrthoDB	EOG7D2FQ4
BioCyc	YEAST:G3O-30534-MONOMER
NextBio	972499
Proteomes	UP000002311
Genevestigator	P12383
GO	GO:0005829 GO:0005634 GO:0003677 GO:0001077 GO:0008270 GO:2001040 GO:0045944
Gene3D	4.10.240.10
InterPro	IPR007219 IPR001138
Pfam	PF04082 PF00172
SMART	SM00906 SM00066
SUPFAM	SSF57701
PROSITE	PS00463 PS50048

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071409	cellular response to cycloheximide	PMID:23036859^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0036003) has_regulation_target:(UniProtKB:P33302) causally_upstream_of:(GO:0060548)	Seeded From UniProt	complete
involved_in	GO:0071409	cellular response to cycloheximide	PMID:23036859^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P32527	P	causally_upstream_of:(GO:0036003) has_regulation_target:(UniProtKB:P33302) causally_upstream_of:(GO:0060548)	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:23036859^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071409) part_of:(GO:0036003) has_regulation_target:(UniProtKB:P33302)	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:23036859^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P32527	P	part_of:(GO:0071409) part_of:(GO:0036003) has_regulation_target:(UniProtKB:P33302)	Seeded From UniProt	complete
involved_in	GO:2001040	positive regulation of cellular response to drug	PMID:9767597^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(SGD:S000002418)	Seeded From UniProt	complete
involved_in	GO:2001040	positive regulation of cellular response to drug	PMID:8078477^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000101	P		Seeded From UniProt	complete
involved_in	GO:2001040	positive regulation of cellular response to drug	PMID:15713640^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8798494^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P33302) happens_during:(GO:0035690)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9428726^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P51533) happens_during:(GO:0035690)\|has_regulation_target(UniProtKB:Q04182) happens_during:(GO:0035690)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22932476^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071456)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22932476^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11136452^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:9428726^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:8798494^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001138 InterPro:IPR036864	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007219	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001138 InterPro:IPR007219 InterPro:IPR036864	C		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007219	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001138 InterPro:IPR036864	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001138 InterPro:IPR007219 InterPro:IPR036864	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ducett, JK et al. (2013) Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription. J. Mol. Biol. 425 19-31 PubMed GONUTS page
↑ Cui, Z et al. (1998) Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol. Microbiol. 29 1307-15 PubMed GONUTS page
↑ Delaveau, T et al. (1994) PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol. Gen. Genet. 244 501-11 PubMed GONUTS page
↑ Lucau-Danila, A et al. (2005) Early expression of yeast genes affected by chemical stress. Mol. Cell. Biol. 25 1860-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Katzmann, DJ et al. (1996) Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J. Biol. Chem. 271 23049-54 PubMed GONUTS page
↑ ^6.0 ^6.1 Wolfger, H et al. (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett. 418 269-74 PubMed GONUTS page
↑ ^7.0 ^7.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page
↑ Delahodde, A et al. (2001) Pse1/Kap121-dependent nuclear localization of the major yeast multidrug resistance (MDR) transcription factor Pdr1. Mol. Microbiol. 39 304-12 PubMed GONUTS page

[PMID:23036859-1] 1.0 ^1.1 ^1.2 ^1.3 Ducett, JK et al. (2013) Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription. J. Mol. Biol. 425 19-31 PubMed GONUTS page

[PMID:9767597-2] Cui, Z et al. (1998) Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol. Microbiol. 29 1307-15 PubMed GONUTS page

[PMID:8078477-3] Delaveau, T et al. (1994) PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol. Gen. Genet. 244 501-11 PubMed GONUTS page

[PMID:15713640-4] Lucau-Danila, A et al. (2005) Early expression of yeast genes affected by chemical stress. Mol. Cell. Biol. 25 1860-8 PubMed GONUTS page

[PMID:8798494-5] 5.0 ^5.1 Katzmann, DJ et al. (1996) Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J. Biol. Chem. 271 23049-54 PubMed GONUTS page

[PMID:9428726-6] 6.0 ^6.1 Wolfger, H et al. (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett. 418 269-74 PubMed GONUTS page

[PMID:22932476-7] 7.0 ^7.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page

[PMID:11136452-8] Delahodde, A et al. (2001) Pse1/Kap121-dependent nuclear localization of the major yeast multidrug resistance (MDR) transcription factor Pdr1. Mol. Microbiol. 39 304-12 PubMed GONUTS page

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YEAST:PDR1

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