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YEAST:NPT1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | NPT1 | |
| Protein Name(s) | Nicotinate phosphoribosyltransferase
NAPRTase | |
| External Links | ||
| UniProt | P39683 | |
| EMBL | Z36878 Z75117 L11274 BK006948 | |
| PIR | S67101 | |
| RefSeq | NP_014852.1 | |
| PDB | 1VLP | |
| PDBsum | 1VLP | |
| ProteinModelPortal | P39683 | |
| SMR | P39683 | |
| BioGrid | 34604 | |
| DIP | DIP-4984N | |
| IntAct | P39683 | |
| MINT | MINT-567492 | |
| STRING | 4932.YOR209C | |
| MaxQB | P39683 | |
| PaxDb | P39683 | |
| PeptideAtlas | P39683 | |
| EnsemblFungi | [example_ID YOR209C] | |
| GeneID | 854384 | |
| KEGG | sce:YOR209C | |
| CYGD | YOR209c | |
| SGD | S000005735 | |
| eggNOG | COG1488 | |
| HOGENOM | HOG000284928 | |
| InParanoid | P39683 | |
| KO | K00763 | |
| OMA | KLTMQCA | |
| OrthoDB | EOG71K6C8 | |
| BioCyc | YEAST:YOR209C-MONOMER | |
| BRENDA | 2.4.2.11 | |
| UniPathway | UPA00253 | |
| EvolutionaryTrace | P39683 | |
| NextBio | 976529 | |
| PRO | PR:P39683 | |
| Proteomes | UP000002311 | |
| Genevestigator | P39683 | |
| GO | GO:0005737 GO:0005634 GO:0016874 GO:0004516 GO:0004514 GO:0000183 GO:0006348 GO:0009435 GO:0019358 GO:0001302 | |
| InterPro | IPR006406 IPR007229 IPR002638 | |
| PANTHER | PTHR11098 | |
| Pfam | PF04095 | |
| PIRSF | PIRSF000484 | |
| SUPFAM | SSF51690 | |
| TIGRFAMs | TIGR01514 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016887 |
ATPase activity |
ECO:0000315 |
F |
Investigators report failure of APTase activity in npt1-null yeast mutants. |
complete | |||||
|
involved_in |
GO:0019358 |
nicotinate nucleotide salvage |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006348 |
chromatin silencing at telomere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001302 |
replicative cell aging |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000183 |
chromatin silencing at rDNA |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034355 |
NAD salvage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000120696 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009435 |
NAD biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10742 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10742 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10742 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0006348 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004514 |
nicotinate-nucleotide diphosphorylase (carboxylating) activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009435 |
NAD biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019357 |
nicotinate nucleotide biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004516 |
nicotinate phosphoribosyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016874 |
ligase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019363 |
pyridine nucleotide biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009435 |
NAD biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00253 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Rajavel, M et al. (1998) Conversion of a cosubstrate to an inhibitor: phosphorylation mutants of nicotinic acid phosphoribosyltransferase. Biochemistry 37 4181-8 PubMed GONUTS page
- ↑ 2.0 2.1 Anderson, RM et al. (2002) Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J. Biol. Chem. 277 18881-90 PubMed GONUTS page
- ↑ 3.0 3.1 Sandmeier, JJ et al. (2002) Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics 160 877-89 PubMed GONUTS page
- ↑ Lin, SJ et al. (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289 2126-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
d
f
n
- GO:0009435 ! NAD biosynthetic process
- GO:0034355 ! NAD salvage
- GO:0004514 ! nicotinate-nucleotide diphosphorylase (carboxylating) activity
- GO:0019357 ! nicotinate nucleotide biosynthetic process
- GO:0019358 ! nicotinate nucleotide salvage
- GO:0004516 ! nicotinate phosphoribosyltransferase activity
- GO:0005634 ! nucleus
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