YEAST:NEJ1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	NEJ1 (synonyms: LIF2)
Protein Name(s)	Non-homologous end-joining protein 1
External Links
UniProt	Q06148
EMBL	AM296374 AM296375 AM296376 AM296377 AM296378 AM296379 AM296380 AM296381 AM296382 AM296383 AM296384 AM296385 AM296386 U17244 AY557954 BK006945
PIR	S51402
RefSeq	NP_013367.1
ProteinModelPortal	Q06148
BioGrid	31533
DIP	DIP-4776N
IntAct	Q06148
MINT	MINT-521085
MaxQB	Q06148
PaxDb	Q06148
EnsemblFungi	[example_ID YLR265C]
GeneID	850970
KEGG	sce:YLR265C
CYGD	YLR265c
SGD	S000004255
eggNOG	NOG73500
InParanoid	Q06148
KO	K10983
OrthoDB	EOG786HD4
BioCyc	YEAST:G3O-32365-MONOMER
NextBio	967466
Proteomes	UP000002311
Genevestigator	Q06148
GO	GO:0005737 GO:0032807 GO:0016021 GO:0031965 GO:0005634 GO:0045027 GO:0006303 GO:0045002
InterPro	IPR015381
Pfam	PF09302

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0045027	DNA end binding	PMID:21149442^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045002	double-strand break repair via single-strand annealing	PMID:19571008^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032807	DNA ligase IV complex	PMID:17567543^[3]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000003058 SGD:S000005531	C	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:18245831^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:11676923^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11676923^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070419	nonhomologous end joining complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002085789 UniProtKB:Q9H9Q4	C	Seeded From UniProt	complete
enables	GO:0045027	DNA end binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002085789 SGD:S000004255	F	Seeded From UniProt	complete
part_of	GO:0032807	DNA ligase IV complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002085789 SGD:S000004255	C	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002085789 PomBase:SPCC24B10.14c SGD:S000004255 UniProtKB:Q9H9Q4	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015381	C	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015381	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chen, X & Tomkinson, AE (2011) Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining. J. Biol. Chem. 286 4931-40 PubMed GONUTS page
↑ Carter, SD et al. (2009) Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism. Proc. Natl. Acad. Sci. U.S.A. 106 12037-42 PubMed GONUTS page
↑ Deshpande, RA & Wilson, TE (2007) Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4. DNA Repair (Amst.) 6 1507-16 PubMed GONUTS page
↑ Wu, D et al. (2008) Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics 178 1237-49 PubMed GONUTS page
↑ ^5.0 ^5.1 Kegel, A et al. (2001) Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast. Curr. Biol. 11 1611-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21149442-1] Chen, X & Tomkinson, AE (2011) Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining. J. Biol. Chem. 286 4931-40 PubMed GONUTS page

[PMID:19571008-2] Carter, SD et al. (2009) Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism. Proc. Natl. Acad. Sci. U.S.A. 106 12037-42 PubMed GONUTS page

[PMID:17567543-3] Deshpande, RA & Wilson, TE (2007) Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4. DNA Repair (Amst.) 6 1507-16 PubMed GONUTS page

[PMID:18245831-4] Wu, D et al. (2008) Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics 178 1237-49 PubMed GONUTS page

[PMID:11676923-5] 5.0 ^5.1 Kegel, A et al. (2001) Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast. Curr. Biol. 11 1611-7 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:NEJ1

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