YEAST:MUC1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	MUC1 (synonyms: FLO11, MAL5, S1, S2)
Protein Name(s)	Flocculation protein FLO11 Flocculin-11 Mucin-like protein 1
External Links
UniProt	P08640
EMBL	Z38061 M16164 M16165 X13857 BK006942
PIR	S48478
RefSeq	NP_012284.3
ProteinModelPortal	P08640
BioGrid	35011
IntAct	P08640
MINT	MINT-2782681
PeptideAtlas	P08640
EnsemblFungi	[example_ID YIR019C]
GeneID	854836
KEGG	sce:YIR019C
CYGD	YIR019c
SGD	S000001458
eggNOG	NOG12793
GeneTree	ENSGT00730000112629
KO	K01178
OMA	ADQFTYV
OrthoDB	EOG7S7SS8
BioCyc	YEAST:G3O-31439-MONOMER
NextBio	977713
PRO	PR:P08640
Genevestigator	P08640
GO	GO:0031225 GO:0005618 GO:0005935 GO:0005576 GO:0005886 GO:0042710 GO:0030447 GO:0000128 GO:0001403 GO:0007124 GO:0016337
InterPro	IPR018789
Pfam	PF10182

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0044409	entry into host	PMID:17921350^[1]	ECO:0000315			P	Figure 1B showed the sigma1278b strain plated onto agar before and after washing. The WT could grow into the agar while the flo11 knockout could not	complete CACAO 9937
	GO:0000128	flocculation	PMID:17921350^[1]	ECO:0000315			P	Figure 1A: Flocculation assay tests whether or not the cells aggregate together and drop to the bottom of the tube. The yeast does flocculate in the WT as the cells collect at the bottom. The knockout stays cloudy in the entire solution for the whole time.	complete CACAO 9938
	GO:0043708	cell adhesion involved in biofilm formation	PMID:17921350^[1]	ECO:0000315			P	Figure 1D: Adherence assay. Growing strain on plastic tests biofilm formation capabilities. There is growth seen on the WT plate but not with the knockout.	complete CACAO 9939
	GO:0016337	cell-cell adhesion	PMID:17921350^[1]	ECO:0000315			P	Figure 4 - Bead adhesion assay. Beads coated with the cells are placed on the plate to test cell-to-cell adhesion. In the WT, the growth is focused around the beads (black dots), while the growth in the knockout is not focused around the beads and is spread out around the plate.	complete CACAO 9940
	GO:0030447	response to nitrate starvation	PMID:17921350^[1]	ECO:0000315			P	Figure 1C: Pictures of yeast plated. FLO11 gene controls hyphae (filaments) formation. WT grows hyphae in order to find more nutrients, while the knockout does not.	complete CACAO 9941
part_of	GO:0000324	fungal-type vacuole	PMID:26928762^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0036281	coflocculation	PMID:26317200^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090606	single-species surface biofilm formation	PMID:12024013^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044011	single-species biofilm formation on inanimate substrate	PMID:19160455^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043709	cell adhesion involved in single-species biofilm formation	PMID:11157168^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044011	single-species biofilm formation on inanimate substrate	PMID:11157168^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090606	single-species surface biofilm formation	PMID:19160455^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:19160455^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030447	filamentous growth	PMID:12072450^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:21875945^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007124	pseudohyphal growth	PMID:8710886^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005935	cellular bud neck	PMID:19799621^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11027318^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:20619652^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001403	invasive growth in response to glucose limitation	PMID:8710886^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001403	invasive growth in response to glucose limitation	PMID:12150916^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001403	invasive growth in response to glucose limitation	PMID:19087208^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000128	flocculation	PMID:19160455^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25960408^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08640	F	Seeded From UniProt	complete
part_of	GO:0005618	cell wall	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0134 UniProtKB-SubCell:SL-0041	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Douglas, LM et al. (2007) Expression and characterization of the flocculin Flo11/Muc1, a Saccharomyces cerevisiae mannoprotein with homotypic properties of adhesion. Eukaryotic Cell 6 2214-21 PubMed GONUTS page
↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
↑ Rossouw, D et al. (2015) Co-Flocculation of Yeast Species, a New Mechanism to Govern Population Dynamics in Microbial Ecosystems. PLoS ONE 10 e0136249 PubMed GONUTS page
↑ Kuchin, S et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol. Cell. Biol. 22 3994-4000 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Fidalgo, M et al. (2008) Coding repeat instability in the FLO11 gene of Saccharomyces yeasts. Yeast 25 879-89 PubMed GONUTS page
↑ ^6.0 ^6.1 Reynolds, TB & Fink, GR (2001) Bakers' yeast, a model for fungal biofilm formation. Science 291 878-81 PubMed GONUTS page
↑ Laprade, L et al. (2002) Spt3 plays opposite roles in filamentous growth in Saccharomyces cerevisiae and Candida albicans and is required for C. albicans virulence. Genetics 161 509-19 PubMed GONUTS page
↑ Váchová, L et al. (2011) Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. J. Cell Biol. 194 679-87 PubMed GONUTS page
↑ ^9.0 ^9.1 Lambrechts, MG et al. (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc. Natl. Acad. Sci. U.S.A. 93 8419-24 PubMed GONUTS page
↑ Vopálenská, I et al. (2010) Role of distinct dimorphic transitions in territory colonizing and formation of yeast colony architecture. Environ. Microbiol. 12 264-77 PubMed GONUTS page
↑ Guo, B et al. (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc. Natl. Acad. Sci. U.S.A. 97 12158-63 PubMed GONUTS page
↑ Karunanithi, S et al. (2010) Shedding of the mucin-like flocculin Flo11p reveals a new aspect of fungal adhesion regulation. Curr. Biol. 20 1389-95 PubMed GONUTS page
↑ Harashima, T & Heitman, J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol. Cell 10 163-73 PubMed GONUTS page
↑ Van Mulders, SE et al. (2009) Phenotypic diversity of Flo protein family-mediated adhesion in Saccharomyces cerevisiae. FEMS Yeast Res. 9 178-90 PubMed GONUTS page
↑ Kraushaar, T et al. (2015) Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-like Adhesin Domain Girdled by Aromatic Bands. Structure 23 1005-17 PubMed GONUTS page

[PMID:17921350-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Douglas, LM et al. (2007) Expression and characterization of the flocculin Flo11/Muc1, a Saccharomyces cerevisiae mannoprotein with homotypic properties of adhesion. Eukaryotic Cell 6 2214-21 PubMed GONUTS page

[PMID:26928762-2] Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page

[PMID:26317200-3] Rossouw, D et al. (2015) Co-Flocculation of Yeast Species, a New Mechanism to Govern Population Dynamics in Microbial Ecosystems. PLoS ONE 10 e0136249 PubMed GONUTS page

[PMID:12024013-4] Kuchin, S et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol. Cell. Biol. 22 3994-4000 PubMed GONUTS page

[PMID:19160455-5] 5.0 ^5.1 ^5.2 ^5.3 Fidalgo, M et al. (2008) Coding repeat instability in the FLO11 gene of Saccharomyces yeasts. Yeast 25 879-89 PubMed GONUTS page

[PMID:11157168-6] 6.0 ^6.1 Reynolds, TB & Fink, GR (2001) Bakers' yeast, a model for fungal biofilm formation. Science 291 878-81 PubMed GONUTS page

[PMID:12072450-7] Laprade, L et al. (2002) Spt3 plays opposite roles in filamentous growth in Saccharomyces cerevisiae and Candida albicans and is required for C. albicans virulence. Genetics 161 509-19 PubMed GONUTS page

[PMID:21875945-8] Váchová, L et al. (2011) Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. J. Cell Biol. 194 679-87 PubMed GONUTS page

[PMID:8710886-9] 9.0 ^9.1 Lambrechts, MG et al. (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc. Natl. Acad. Sci. U.S.A. 93 8419-24 PubMed GONUTS page

[PMID:19799621-10] Vopálenská, I et al. (2010) Role of distinct dimorphic transitions in territory colonizing and formation of yeast colony architecture. Environ. Microbiol. 12 264-77 PubMed GONUTS page

[PMID:11027318-11] Guo, B et al. (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc. Natl. Acad. Sci. U.S.A. 97 12158-63 PubMed GONUTS page

[PMID:20619652-12] Karunanithi, S et al. (2010) Shedding of the mucin-like flocculin Flo11p reveals a new aspect of fungal adhesion regulation. Curr. Biol. 20 1389-95 PubMed GONUTS page

[PMID:12150916-13] Harashima, T & Heitman, J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol. Cell 10 163-73 PubMed GONUTS page

[PMID:19087208-14] Van Mulders, SE et al. (2009) Phenotypic diversity of Flo protein family-mediated adhesion in Saccharomyces cerevisiae. FEMS Yeast Res. 9 178-90 PubMed GONUTS page

[PMID:25960408-15] Kraushaar, T et al. (2015) Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-like Adhesin Domain Girdled by Aromatic Bands. Structure 23 1005-17 PubMed GONUTS page

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YEAST:MUC1

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