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PMID:19160455

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Citation

Fidalgo, M, Barrales, RR and Jimenez, J (2008) Coding repeat instability in the FLO11 gene of Saccharomyces yeasts. Yeast 25:879-89

Abstract

In Saccharomyces yeasts, the FLO11 gene encodes an adhesin involved in filamentation, invasive growth, flocculation and adherence to solid surfaces. In wild Saccharomyces flor yeasts, a particularly expanded FLO11 allele also confers to these yeasts the ability to float under stressing liquid environments. We report here that, under optimal laboratory conditions, the repeats domain of the FLO11 gene in these wild yeasts is extremely unstable. Changes in length in the FLO11 coding repeats domain affected Flo11p-associated functions but, interestingly, some of these functions were affected more than others. Therefore, length variations in this single gene provide a combinatorial diversity, which may contribute to a very rapid adaptation to fluctuating environments. Functional analysis of contracted alleles indicated that buoyancy was not associated to FLO11 length. In contrast, this property depended on the different types of repetitive units found in this gene. Thus, not only variations in the number of intragenic repeats but also the abundance and/or distribution of the different repetitive units may have phenotypic and evolutionary implications.

Links

PubMed Online version:10.1002/yea.1642

Keywords

Adaptation, Physiological; Amino Acid Sequence; Evolution, Molecular; Gene Expression Regulation, Fungal; Membrane Glycoproteins; Membrane Proteins/genetics; Molecular Sequence Data; Mutation; Phenotype; Polymorphism, Genetic; Recombination, Genetic; Repetitive Sequences, Nucleic Acid/genetics; Saccharomyces/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae Proteins/genetics; Tandem Repeat Sequences/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

YEAST:FLO11

involved_in

GO:0000128: flocculation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:FLO11

involved_in

GO:0044011: single-species biofilm formation on inanimate substrate

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:FLO11

involved_in

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:FLO11

involved_in

GO:0090606: single-species surface biofilm formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:MUC1

involved_in

GO:0098609: cell-cell adhesion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:MUC1

involved_in

GO:0090606: single-species surface biofilm formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:MUC1

involved_in

GO:0044011: single-species biofilm formation on inanimate substrate

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

YEAST:MUC1

involved_in

GO:0000128: flocculation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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