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YEAST:MLP1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | MLP1 | |
| Protein Name(s) | Protein MLP1
Myosin-like protein 1 | |
| External Links | ||
| UniProt | Q02455 | |
| EMBL | L01992 X73541 Z28320 BK006944 | |
| PIR | S38173 | |
| RefSeq | NP_013021.1 | |
| ProteinModelPortal | Q02455 | |
| BioGrid | 34226 | |
| DIP | DIP-6675N | |
| IntAct | Q02455 | |
| MINT | MINT-622372 | |
| STRING | 4932.YKR095W | |
| TCDB | 1.I.1.1.1 | |
| MaxQB | Q02455 | |
| PaxDb | Q02455 | |
| PeptideAtlas | Q02455 | |
| PRIDE | Q02455 | |
| EnsemblFungi | [example_ID YKR095W] | |
| GeneID | 853970 | |
| KEGG | sce:YKR095W | |
| CYGD | YKR095w | |
| SGD | S000001803 | |
| eggNOG | NOG12793 | |
| GeneTree | ENSGT00730000111014 | |
| HOGENOM | HOG000113604 | |
| InParanoid | Q02455 | |
| KO | K09291 | |
| OMA | TRESTEN | |
| OrthoDB | EOG7BP89V | |
| BioCyc | YEAST:G3O-32058-MONOMER | |
| NextBio | 975413 | |
| PRO | PR:Q02455 | |
| Proteomes | UP000002311 | |
| Genevestigator | Q02455 | |
| GO | GO:0005635 GO:0044615 GO:0005654 GO:0043021 GO:0006281 GO:1901925 GO:0071048 GO:0016973 GO:0006606 GO:0090204 GO:0034398 GO:0090203 | |
| InterPro | IPR001611 IPR012929 | |
| Pfam | PF07926 | |
| PROSITE | PS51450 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0090202 |
gene looping |
ECO:0000314 |
P |
Mlp1 is required from gene loop maintenance during glucose shutdown as shown in Figure 1 through a PolII-ChIP analysis. |
complete | |||||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901925 |
negative regulation of protein import into nucleus during spindle assembly checkpoint |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001411 |
P |
has_input:(UniProtKB:P07270) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0090204 |
protein localization to nuclear pore |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090203 |
transcriptional activation by promoter-terminator looping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071048 |
nuclear retention of unspliced pre-mRNA at the site of transcription |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000003238 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071048 |
nuclear retention of unspliced pre-mRNA at the site of transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044615 |
nuclear pore nuclear basket |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043021 |
ribonucleoprotein complex binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043021 |
ribonucleoprotein complex binding |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0034398 |
telomere tethering at nuclear periphery |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001411 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016973 |
poly(A)+ mRNA export from nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006606 |
protein import into nucleus |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
colocalizes_with |
GO:0005816 |
spindle pole body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017056 |
structural constituent of nuclear pore |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001052033 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007094 |
mitotic spindle assembly checkpoint |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0013756 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005643 |
nuclear pore |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0013756 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006606 |
protein import into nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051028 |
mRNA transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Tan-Wong, SM et al. (2009) Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex. Genes Dev. 23 2610-24 PubMed GONUTS page
- ↑ Mitchell, SF et al. (2013) Global analysis of yeast mRNPs. Nat. Struct. Mol. Biol. 20 127-33 PubMed GONUTS page
- ↑ Cairo, LV et al. (2013) Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p. Mol. Cell 49 109-20 PubMed GONUTS page
- ↑ 4.0 4.1 Galy, V et al. (2004) Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1. Cell 116 63-73 PubMed GONUTS page
- ↑ Niepel, M et al. (2013) The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Mol. Biol. Cell 24 3920-38 PubMed GONUTS page
- ↑ 6.0 6.1 Vinciguerra, P et al. (2005) Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export. EMBO J. 24 813-23 PubMed GONUTS page
- ↑ Galy, V et al. (2000) Nuclear pore complexes in the organization of silent telomeric chromatin. Nature 403 108-12 PubMed GONUTS page
- ↑ Powrie, EA et al. (2011) A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae. RNA 17 134-44 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Strambio-de-Castillia, C et al. (1999) Proteins connecting the nuclear pore complex with the nuclear interior. J. Cell Biol. 144 839-55 PubMed GONUTS page
- ↑ Niepel, M et al. (2005) The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly. J. Cell Biol. 170 225-35 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
f
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- GO:1901925 ! negative regulation of protein import into nucleus during spindle assembly checkpoint
- GO:0005635 ! nuclear envelope
- GO:0005643 ! nuclear pore
- GO:0044615 ! nuclear pore nuclear basket
- GO:0071048 ! nuclear retention of unspliced pre-mRNA at the site of transcription
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
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