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YEAST:MID2

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) MID2 (synonyms: KAI1, SMS1)
Protein Name(s) Cell wall integrity sensor MID2

Mating pheromone-induced death protein 2 Protein kinase A interference protein 1 Serine-rich multicopy suppressor protein 1

External Links
UniProt P36027
EMBL D29945
D29964
U20618
BK006945
PIR S52137
RefSeq NP_013436.1
ProteinModelPortal P36027
BioGrid 31595
DIP DIP-4676N
IntAct P36027
MINT MINT-533780
STRING 4932.YLR332W
MaxQB P36027
PaxDb P36027
EnsemblFungi [example_ID YLR332W]
GeneID 851042
KEGG sce:YLR332W
CYGD YLR332w
SGD S000004324
eggNOG NOG39007
GeneTree ENSGT00730000113634
InParanoid P36027
KO K11245
OMA NANTADH
OrthoDB EOG7Z3FGC
BioCyc YEAST:G3O-32412-MONOMER
NextBio 967648
Proteomes UP000002311
Genevestigator P36027
GO GO:0005887
GO:0004888
GO:0000767
GO:0031505
GO:0030242
GO:0010447
GO:0006970
GO:0030969
InterPro IPR007567
Pfam PF04478

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0000324

fungal-type vacuole

PMID:26928762[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043332

mating projection tip

PMID:19053807[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031505

fungal-type cell wall organization

PMID:10348843[3]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000000201
SGD:S000005534
SGD:S000006369

P

Seeded From UniProt

complete

involved_in

GO:0031505

fungal-type cell wall organization

PMID:11014808[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036498

IRE1-mediated unfolded protein response

PMID:18971375[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030242

autophagy of peroxisome

PMID:20385774[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006970

response to osmotic stress

PMID:14871941[7]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004478

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:10348843[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

PMID:10330137[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010447

response to acidic pH

PMID:16087742[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000767

cell morphogenesis involved in conjugation

PMID:10330137[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
  2. Narayanaswamy, R et al. (2009) Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J. Proteome Res. 8 6-19 PubMed GONUTS page
  3. 3.0 3.1 Ketela, T et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J. Bacteriol. 181 3330-40 PubMed GONUTS page
  4. Marcoux, N et al. (2000) Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae. Genetics 156 579-92 PubMed GONUTS page
  5. Scrimale, T et al. (2009) The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae. Mol. Biol. Cell 20 164-75 PubMed GONUTS page
  6. Manjithaya, R et al. (2010) A yeast MAPK cascade regulates pexophagy but not other autophagy pathways. J. Cell Biol. 189 303-10 PubMed GONUTS page
  7. Merchan, S et al. (2004) Response of the Saccharomyces cerevisiae Mpk1 mitogen-activated protein kinase pathway to increases in internal turgor pressure caused by loss of Ppz protein phosphatases. Eukaryotic Cell 3 100-7 PubMed GONUTS page
  8. 8.0 8.1 Rajavel, M et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol. Cell. Biol. 19 3969-76 PubMed GONUTS page
  9. Claret, S et al. (2005) The Rgd1p Rho GTPase-activating protein and the Mid2p cell wall sensor are required at low pH for protein kinase C pathway activation and cell survival in Saccharomyces cerevisiae. Eukaryotic Cell 4 1375-86 PubMed GONUTS page