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YEAST:MAD1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) MAD1
Protein Name(s) Spindle assembly checkpoint component MAD1

Mitotic arrest deficient protein 1

External Links
UniProt P40957
EMBL U14632
Z72608
BK006941
PIR A57276
RefSeq NP_011429.3
ProteinModelPortal P40957
BioGrid 33164
DIP DIP-293N
IntAct P40957
MINT MINT-434649
iPTMnet P40957
MaxQB P40957
EnsemblFungi YGL086W
GeneID 852794
KEGG sce:YGL086W
EuPathDB FungiDB:YGL086W
SGD S000003054
HOGENOM HOG000113453
InParanoid P40957
KO K06679
OMA NDKARAR
OrthoDB EOG744TJR
BioCyc YEAST:G3O-30587-MONOMER
PRO PR:P40957
Proteomes UP000002311
GO GO:0000776
GO:0005634
GO:0090268
GO:0051301
GO:0044774
GO:0007067
GO:0007094
GO:1901925
GO:0006913
InterPro IPR008672
PANTHER PTHR23168
Pfam PF05557

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0044877

protein-containing complex binding

PMID:12473689[1]

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(ComplexPortal:CPX-824)

Seeded From UniProt

complete

part_of

GO:0000778

condensed nuclear chromosome kinetochore

PMID:27170178[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000778

condensed nuclear chromosome kinetochore

PMID:24402315[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901925

negative regulation of protein import into nucleus during spindle assembly checkpoint

PMID:23177738[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090268

activation of mitotic cell cycle spindle assembly checkpoint

PMID:15802513[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044774

mitotic DNA integrity checkpoint

PMID:16651657[6]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000005032

P

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

PMID:10704439[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006913

nucleocytoplasmic transport

PMID:12473689[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P38181

P

Seeded From UniProt

complete

involved_in

GO:0006913

nucleocytoplasmic transport

PMID:12473689[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38181

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7593191[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000778

condensed nuclear chromosome kinetochore

PMID:19139260[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000778

condensed nuclear chromosome kinetochore

PMID:19139260[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026326
PANTHER:PTN000570834
UniProtKB:Q9Y6D9

C

Seeded From UniProt

complete

involved_in

GO:0051315

attachment of mitotic spindle microtubules to kinetochore

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026326
PANTHER:PTN000570834

P

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026326
PANTHER:PTN000570834
SGD:S000003054

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026326
PANTHER:PTN000570834
TAIR:locus:2158804
UniProtKB:Q9Y6D9

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026326
MGI:MGI:1341857
PANTHER:PTN000570834
UniProtKB:C8VRP6
UniProtKB:Q9Y6D9
WB:WBGene00003160
dictyBase:DDB_G0287755

C

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008672

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Iouk, T et al. (2002) The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J. Cell Biol. 159 807-19 PubMed GONUTS page
  2. ↑ Aravamudhan, P et al. (2016) Dual mechanisms regulate the recruitment of spindle assembly checkpoint proteins to the budding yeast kinetochore. Mol. Biol. Cell 27 3405-3417 PubMed GONUTS page
  3. ↑ London, N & Biggins, S (2014) Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint. Genes Dev. 28 140-52 PubMed GONUTS page
  4. ↑ Cairo, LV et al. (2013) Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p. Mol. Cell 49 109-20 PubMed GONUTS page
  5. ↑ Kastenmayer, JP et al. (2005) The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association. Genetics 170 509-17 PubMed GONUTS page
  6. ↑ Andrews, CA et al. (2006) A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin. Genes Dev. 20 1162-74 PubMed GONUTS page
  7. ↑ Hardwick, KG et al. (2000) MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p. J. Cell Biol. 148 871-82 PubMed GONUTS page
  8. ↑ Hardwick, KG & Murray, AW (1995) Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131 709-20 PubMed GONUTS page
  9. ↑ 9.0 9.1 Scott, RJ et al. (2009) The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast. J. Cell Biol. 184 21-9 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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