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YEAST:LAG1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) LAG1
Protein Name(s) Sphingosine N-acyltransferase LAG1

Longevity assurance factor 1 Longevity assurance gene 1 protein Longevity assurance protein 1

External Links
UniProt P38703
EMBL U08133
U05335
U10555
AY558514
BK006934
PIR S46800
RefSeq NP_011860.1
ProteinModelPortal P38703
BioGrid 36422
DIP DIP-4393N
IntAct P38703
MINT MINT-515520
SwissLipids SLP:000000276
iPTMnet P38703
MaxQB P38703
PeptideAtlas P38703
EnsemblFungi [example_ID YHL003C]
GeneID 856386
KEGG sce:YHL003C
EuPathDB FungiDB:YHL003C
SGD S000000995
GeneTree ENSGT00730000113269
HOGENOM HOG000216359
InParanoid P38703
KO K04709
OMA HVVNIRI
OrthoDB EOG76DV2T
BioCyc MetaCyc:MONOMER3O-370
YEAST:MONOMER3O-370
NextBio 981890
PRO PR:P38703
Proteomes UP000002311
GO GO:0061576
GO:0005789
GO:0016021
GO:0050291
GO:0046513
GO:0001302
InterPro IPR016439
IPR006634
IPR013599
PANTHER PTHR12560
Pfam PF08390
PF03798
SMART SM00724
PROSITE PS50922

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005783

endoplasmic reticulum

PMID:26928762[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:11914276[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:22842922[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:14562095[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0061576

acyl-CoA ceramide synthase complex

PMID:15692566[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0050291

sphingosine N-acyltransferase activity

PMID:11387200[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050291

sphingosine N-acyltransferase activity

PMID:11694577[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050291

sphingosine N-acyltransferase activity

PMID:15692566[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046513

ceramide biosynthetic process

PMID:11694577[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046513

ceramide biosynthetic process

PMID:15692566[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001302

replicative cell aging

PMID:8195187[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050291

sphingosine N-acyltransferase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040918
MGI:MGI:1914510
MGI:MGI:1919199
MGI:MGI:1924143
MGI:MGI:2136690
MGI:MGI:2442564
MGI:MGI:2681008
PANTHER:PTN000285423
SGD:S000000995
SGD:S000001491
TAIR:locus:2010022
TAIR:locus:2094528
UniProtKB:A0A1D8PKA5
UniProtKB:C8VP84
UniProtKB:Q5B548
UniProtKB:Q8N5B7

F

Seeded From UniProt

complete

involved_in

GO:0046513

ceramide biosynthetic process

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040918
MGI:MGI:1914510
MGI:MGI:1919199
MGI:MGI:1924143
MGI:MGI:2136690
MGI:MGI:2442564
PANTHER:PTN000285423
SGD:S000000995
SGD:S000001491
UniProtKB:C8VP84
UniProtKB:P27544
UniProtKB:Q5B548
UniProtKB:Q8IU89
UniProtKB:Q8N5B7

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040918
MGI:MGI:1914510
MGI:MGI:1919199
MGI:MGI:2442564
PANTHER:PTN000970771
TAIR:locus:2010022
TAIR:locus:2094133
TAIR:locus:2094528
UniProtKB:P27544

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006634

C

Seeded From UniProt

complete

enables

GO:0050291

sphingosine N-acyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.24

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
  2. ↑ Kumar, A et al. (2002) Subcellular localization of the yeast proteome. Genes Dev. 16 707-19 PubMed GONUTS page
  3. ↑ Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page
  4. ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Vallée, B & Riezman, H (2005) Lip1p: a novel subunit of acyl-CoA ceramide synthase. EMBO J. 24 730-41 PubMed GONUTS page
  6. ↑ Guillas, I et al. (2001) C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J. 20 2655-65 PubMed GONUTS page
  7. ↑ 7.0 7.1 Schorling, S et al. (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol. Biol. Cell 12 3417-27 PubMed GONUTS page
  8. ↑ D'mello, NP et al. (1994) Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J. Biol. Chem. 269 15451-9 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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