YEAST:KSP1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	KSP1
Protein Name(s)	Serine/threonine-protein kinase KSP1
External Links
UniProt	P38691
EMBL	X80329 U10556 BK006934
PIR	S64731
RefSeq	NP_011950.1
ProteinModelPortal	P38691
SMR	P38691
BioGrid	36517
DIP	DIP-2972N
IntAct	P38691
MINT	P38691
STRING	4932.YHR082C
iPTMnet	P38691
MaxQB	P38691
PaxDb	P38691
PRIDE	P38691
EnsemblFungi	YHR082C
GeneID	856482
KEGG	sce:YHR082C
EuPathDB	FungiDB:YHR082C
SGD	S000001124
GeneTree	ENSGT00550000075309
HOGENOM	HOG000000880
InParanoid	P38691
KO	K08286
OMA	FDVFSTM
OrthoDB	EOG092C2289
BioCyc	YEAST:G3O-31129-MONOMER
BRENDA	2.7.11.1
PRO	PR:P38691
Proteomes	UP000002311
GO	GO:0005737 GO:0010494 GO:0005634 GO:0005524 GO:0004674 GO:0004712 GO:0034613 GO:0016242 GO:0006468 GO:0010570 GO:2000220 GO:0031929
InterPro	IPR011009 IPR000719 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:22842922^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:23222640^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:16319894^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16319894^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:26777405^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8676864^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19454	F		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:8676864^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22216	F		Seeded From UniProt	complete
involved_in	GO:2000220	regulation of pseudohyphal growth	PMID:22043304^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	PMID:18417610^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:22043304^[6]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000001229	P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:22043304^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	PMID:22447937^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000006389	P		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	PMID:22447937^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010570	regulation of filamentous growth	PMID:18417610^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:23222640^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8676864^[5]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P19454 UniProtKB:P22216	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18417610^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18417610^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8676864^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page
↑ ^2.0 ^2.1 Mitchell, SF et al. (2013) Global analysis of yeast mRNPs. Nat. Struct. Mol. Biol. 20 127-33 PubMed GONUTS page
↑ ^3.0 ^3.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
↑ Jain, S et al. (2016) ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 164 487-98 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Fleischmann, M et al. (1996) Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Mol. Gen. Genet. 250 614-25 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Laxman, S & Tu, BP (2011) Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae. PLoS ONE 6 e26081 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Bharucha, N et al. (2008) Analysis of the yeast kinome reveals a network of regulated protein localization during filamentous growth. Mol. Biol. Cell 19 2708-17 PubMed GONUTS page
↑ ^8.0 ^8.1 Umekawa, M & Klionsky, DJ (2012) Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J. Biol. Chem. 287 16300-10 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22842922-1] Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page

[PMID:23222640-2] 2.0 ^2.1 Mitchell, SF et al. (2013) Global analysis of yeast mRNPs. Nat. Struct. Mol. Biol. 20 127-33 PubMed GONUTS page

[PMID:16319894-3] 3.0 ^3.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page

[PMID:26777405-4] Jain, S et al. (2016) ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 164 487-98 PubMed GONUTS page

[PMID:8676864-5] 5.0 ^5.1 ^5.2 ^5.3 Fleischmann, M et al. (1996) Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Mol. Gen. Genet. 250 614-25 PubMed GONUTS page

[PMID:22043304-6] 6.0 ^6.1 ^6.2 Laxman, S & Tu, BP (2011) Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae. PLoS ONE 6 e26081 PubMed GONUTS page

[PMID:18417610-7] 7.0 ^7.1 ^7.2 ^7.3 Bharucha, N et al. (2008) Analysis of the yeast kinome reveals a network of regulated protein localization during filamentous growth. Mol. Biol. Cell 19 2708-17 PubMed GONUTS page

[PMID:22447937-8] 8.0 ^8.1 Umekawa, M & Klionsky, DJ (2012) Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J. Biol. Chem. 287 16300-10 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:KSP1

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