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YEAST:KPYK2

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) PYK2
Protein Name(s) Pyruvate kinase 2

PK 2

External Links
UniProt P52489
EMBL X95720
Z75255
BK006948
PIR S67256
RefSeq NP_014992.3
ProteinModelPortal P52489
SMR P52489
BioGrid 34732
IntAct P52489
MINT MINT-2783027
MaxQB P52489
PaxDb P52489
PeptideAtlas P52489
EnsemblFungi [example_ID YOR347C]
GeneID 854529
KEGG sce:YOR347C
CYGD YOR347c
EuPathDB FungiDB:YOR347C
SGD S000005874
eggNOG COG0469
GeneTree ENSGT00390000008859
HOGENOM HOG000021559
InParanoid P52489
KO K00873
OMA WHRRTIR
OrthoDB EOG7M6DJC
BioCyc YEAST:YOR347C-MONOMER
Reactome REACT_275254
REACT_298577
REACT_313135
SABIO-RK P52489
UniPathway UPA00109
NextBio 976910
PRO PR:P52489
Proteomes UP000002311
GO GO:0005739
GO:0005524
GO:0000287
GO:0030955
GO:0004743
GO:0006096
GO:0006090
Gene3D 2.40.33.10
3.20.20.60
3.40.1380.20
InterPro IPR001697
IPR015813
IPR011037
IPR015794
IPR018209
IPR015793
IPR015795
IPR015806
PANTHER PTHR11817
Pfam PF00224
PF02887
PRINTS PR01050
SUPFAM SSF50800
SSF51621
SSF52935
TIGRFAMs TIGR01064
PROSITE PS00110

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004743

pyruvate kinase activity

PMID:21907146[1]

ECO:0000316

UniProtKB:P00549


F

Figure 1B and C Pyruvate kinase activity of TEFpr-PYK2 and CYCpr-PYK2. TEFpr is a strong promotor, CYCpr is a weak promotor.

complete
CACAO 10959

GO:0006098

pentose-phosphate shunt

PMID:21907146[1]

ECO:0000314

P

Figure 5B Cells with low PYK activity have increased concentrations of PPP intermediates

complete
CACAO 10961

part_of

GO:0005737

cytoplasm

PMID:14562095[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:9139918[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16962558[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004743

pyruvate kinase activity

PMID:9139918[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032869

cellular response to insulin stimulus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000212861
RGD:3336

P

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10803
EcoGene:EG10804
MGI:MGI:97591
PANTHER:PTN000212670
RGD:3336
RGD:3337
SGD:S000000036
UniProtKB:Q2RAK2

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000212670
SGD:S000000036
UniProtKB:P14618

C

Seeded From UniProt

complete

enables

GO:0004743

pyruvate kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10803
EcoGene:EG10804
MGI:MGI:97591
MGI:MGI:97604
PANTHER:PTN000212670
PomBase:SPAC4H3.10c
RGD:3336
RGD:3337
SGD:S000000036
SGD:S000005874
TAIR:locus:2033760
TAIR:locus:2084583
TAIR:locus:2176912
UniProtKB:C6KTA4
UniProtKB:P14618
UniProtKB:P30613
UniProtKB:Q2RAK2

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001697
InterPro:IPR015793

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015813

F

Seeded From UniProt

complete

enables

GO:0004743

pyruvate kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001697
InterPro:IPR015793
InterPro:IPR015806
InterPro:IPR018209

F

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001697
InterPro:IPR015793
InterPro:IPR015806
InterPro:IPR018209

P

Seeded From UniProt

complete

enables

GO:0030955

potassium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001697
InterPro:IPR015793

F

Seeded From UniProt

complete

enables

GO:0004743

pyruvate kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.40

F

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0324
UniPathway:UPA00109

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Grüning, NM et al. (2011) Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells. Cell Metab. 14 415-27 PubMed GONUTS page
  2. Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
  3. 3.0 3.1 Boles, E et al. (1997) Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate. J. Bacteriol. 179 2987-93 PubMed GONUTS page
  4. Brandina, I et al. () Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim. Biophys. Acta 1757 1217-28 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page