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YEAST:KPYK2
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | PYK2 | |
| Protein Name(s) | Pyruvate kinase 2
PK 2 | |
| External Links | ||
| UniProt | P52489 | |
| EMBL | X95720 Z75255 BK006948 | |
| PIR | S67256 | |
| RefSeq | NP_014992.3 | |
| ProteinModelPortal | P52489 | |
| SMR | P52489 | |
| BioGrid | 34732 | |
| IntAct | P52489 | |
| MINT | MINT-2783027 | |
| MaxQB | P52489 | |
| PaxDb | P52489 | |
| PeptideAtlas | P52489 | |
| EnsemblFungi | [example_ID YOR347C] | |
| GeneID | 854529 | |
| KEGG | sce:YOR347C | |
| CYGD | YOR347c | |
| EuPathDB | FungiDB:YOR347C | |
| SGD | S000005874 | |
| eggNOG | COG0469 | |
| GeneTree | ENSGT00390000008859 | |
| HOGENOM | HOG000021559 | |
| InParanoid | P52489 | |
| KO | K00873 | |
| OMA | WHRRTIR | |
| OrthoDB | EOG7M6DJC | |
| BioCyc | YEAST:YOR347C-MONOMER | |
| Reactome | REACT_275254 REACT_298577 REACT_313135 | |
| SABIO-RK | P52489 | |
| UniPathway | UPA00109 | |
| NextBio | 976910 | |
| PRO | PR:P52489 | |
| Proteomes | UP000002311 | |
| GO | GO:0005739 GO:0005524 GO:0000287 GO:0030955 GO:0004743 GO:0006096 GO:0006090 | |
| Gene3D | 2.40.33.10 3.20.20.60 3.40.1380.20 | |
| InterPro | IPR001697 IPR015813 IPR011037 IPR015794 IPR018209 IPR015793 IPR015795 IPR015806 | |
| PANTHER | PTHR11817 | |
| Pfam | PF00224 PF02887 | |
| PRINTS | PR01050 | |
| SUPFAM | SSF50800 SSF51621 SSF52935 | |
| TIGRFAMs | TIGR01064 | |
| PROSITE | PS00110 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004743 |
pyruvate kinase activity |
ECO:0000316 |
|
F |
Figure 1B and C Pyruvate kinase activity of TEFpr-PYK2 and CYCpr-PYK2. TEFpr is a strong promotor, CYCpr is a weak promotor. |
complete | ||||
| GO:0006098 |
pentose-phosphate shunt |
ECO:0000314 |
P |
Figure 5B Cells with low PYK activity have increased concentrations of PPP intermediates |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006090 |
pyruvate metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004743 |
pyruvate kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000212861 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006096 |
glycolytic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10803 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000212670 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004743 |
pyruvate kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10803 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004743 |
pyruvate kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001697 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006096 |
glycolytic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001697 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030955 |
potassium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004743 |
pyruvate kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006096 |
glycolytic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0324 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Grüning, NM et al. (2011) Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells. Cell Metab. 14 415-27 PubMed GONUTS page
- ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
- ↑ 3.0 3.1 Boles, E et al. (1997) Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate. J. Bacteriol. 179 2987-93 PubMed GONUTS page
- ↑ Brandina, I et al. () Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim. Biophys. Acta 1757 1217-28 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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