YEAST:KIN4

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	KIN4 (synonyms: KIN3, KIN31)
Protein Name(s)	Serine/threonine-protein kinase KIN4
External Links
UniProt	Q01919
EMBL	X67916 Z75141 BK006948
PIR	S29344
RefSeq	NP_014876.1
ProteinModelPortal	Q01919
SMR	Q01919
BioGrid	34626
DIP	DIP-7214N
IntAct	Q01919
MINT	MINT-2786026
STRING	4932.YOR233W
MaxQB	Q01919
PaxDb	Q01919
PRIDE	Q01919
EnsemblFungi	[example_ID YOR233W]
GeneID	854408
KEGG	sce:YOR233W
CYGD	YOR233w
SGD	S000005759
eggNOG	COG0515
GeneTree	ENSGT00770000120521
HOGENOM	HOG000247883
InParanoid	Q01919
KO	K08286
OMA	EMREREP
OrthoDB	EOG793BK1
BioCyc	YEAST:G3O-33731-MONOMER
BRENDA	2.7.11.1
NextBio	976595
PRO	PR:Q01919
Proteomes	UP000002311
Genevestigator	Q01919
GO	GO:0005938 GO:0005935 GO:0005816 GO:0005524 GO:0004674 GO:0031578 GO:0071988 GO:0006468
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006468	protein phosphorylation	PMID:16319894^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:16319894^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24850890^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(SGD:S000003814)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17967947^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(SGD:S000003814)	Seeded From UniProt	complete
involved_in	GO:0071988	protein localization to spindle pole body	PMID:24850890^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(SGD:S000003814)	Seeded From UniProt	complete
involved_in	GO:0031578	mitotic spindle orientation checkpoint	PMID:16039590^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031578	mitotic spindle orientation checkpoint	PMID:16039591^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8465601^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06782 UniProtKB:P13185 UniProtKB:P13186	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:16039591^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005935	cellular bud neck	PMID:16039591^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005816	spindle pole body	PMID:16039590^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8465601^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06782 UniProtKB:P13185 UniProtKB:P13186	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001217432 SGD:S000005759	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034674	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR034674	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
↑ ^2.0 ^2.1 Caydasi, AK et al. (2014) The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes. Mol. Biol. Cell 25 2143-51 PubMed GONUTS page
↑ Maekawa, H et al. (2007) The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal. J. Cell Biol. 179 423-36 PubMed GONUTS page
↑ ^4.0 ^4.1 Pereira, G & Schiebel, E (2005) Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol. Cell 19 209-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 D'Aquino, KE et al. (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol. Cell 19 223-34 PubMed GONUTS page
↑ ^6.0 ^6.1 Kambouris, NG et al. (1993) Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae. Yeast 9 141-50 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16319894-1] 1.0 ^1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page

[PMID:24850890-2] 2.0 ^2.1 Caydasi, AK et al. (2014) The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes. Mol. Biol. Cell 25 2143-51 PubMed GONUTS page

[PMID:17967947-3] Maekawa, H et al. (2007) The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal. J. Cell Biol. 179 423-36 PubMed GONUTS page

[PMID:16039590-4] 4.0 ^4.1 Pereira, G & Schiebel, E (2005) Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol. Cell 19 209-21 PubMed GONUTS page

[PMID:16039591-5] 5.0 ^5.1 ^5.2 D'Aquino, KE et al. (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol. Cell 19 223-34 PubMed GONUTS page

[PMID:8465601-6] 6.0 ^6.1 Kambouris, NG et al. (1993) Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae. Yeast 9 141-50 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:KIN4

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