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YEAST:GEF1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) GEF1 (synonyms: CLCY1)
Protein Name(s) Anion/proton exchange transporter GEF1

CLC protein GEF1 ClC-A ClC-Y1 Voltage-gated chloride channel GEF1 N-terminal GEF1 C-terminal

External Links
UniProt P37020
EMBL Z23117
L29347
Z49540
L36344
BK006943
PIR S50054
RefSeq NP_012574.1
ProteinModelPortal P37020
SMR P37020
BioGrid 33791
DIP DIP-3949N
IntAct P37020
MINT MINT-492781
STRING 4932.YJR040W
TCDB 2.A.49.1.1
MaxQB P37020
PaxDb P37020
EnsemblFungi [example_ID YJR040W]
GeneID 853497
KEGG sce:YJR040W
SGD S000003801
eggNOG COG0038
GeneTree ENSGT00760000119109
HOGENOM HOG000164493
InParanoid P37020
KO K05012
OMA DENTHAF
OrthoDB EOG72RN6P
BioCyc YEAST:G3O-31675-MONOMER
Reactome REACT_204366
NextBio 974134
Proteomes UP000002311
Genevestigator P37020
GO GO:0034707
GO:0005783
GO:0005789
GO:0005768
GO:0010008
GO:0000324
GO:0005794
GO:0005797
GO:0000139
GO:0005886
GO:0005774
GO:0030554
GO:0005247
GO:0006878
GO:0006879
GO:0044070
Gene3D 1.10.3080.10
InterPro IPR000644
IPR014743
IPR001807
Pfam PF00571
PF00654
PRINTS PR00762
SMART SM00116
SUPFAM SSF81340
PROSITE PS51371

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0034756

regulation of iron ion transport

PMID:9520490[1]

ECO:0000315

P

Fig 2 shows different levels of iron uptake between wild type and gef1 mutants.

complete
CACAO 4286

GO:0005794

Golgi apparatus

PMID:9614122[2]

ECO:0000314

C

Figure 2 shows that Gef1p is localized to the Golgi.

complete
CACAO 11727

involved_in

GO:0034756

regulation of iron ion transport

PMID:9520490[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

PMID:9520490[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006878

cellular copper ion homeostasis

PMID:9520490[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006878

cellular copper ion homeostasis

PMID:9614122[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:17662057[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005797

Golgi medial cisterna

PMID:9614122[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:15710404[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:17662057[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:15710404[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005247

voltage-gated chloride channel activity

PMID:12074596[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000324

fungal-type vacuole

PMID:17662057[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0031404

chloride ion binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12331
PANTHER:PTN000189250

F

Seeded From UniProt

complete

enables

GO:0015299

solute:proton antiporter activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12331
PANTHER:PTN000189250

F

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000914046
SGD:S000003801

P

Seeded From UniProt

complete

involved_in

GO:0006878

cellular copper ion homeostasis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000914046
SGD:S000003801

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12331
PANTHER:PTN000189250

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12331
PANTHER:PTN000189250
RGD:621219
SGD:S000003801
UniProtKB:A0A1D8PS75
UniProtKB:P51790
UniProtKB:P51795

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002269368
SGD:S000003801
UniProtKB:P51790
UniProtKB:P51795

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000914046
SGD:S000003801

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036566
PANTHER:PTN002269368
UniProtKB:P51790

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103555
MGI:MGI:99486
PANTHER:PTN002269368
RGD:2362
SGD:S000003801

C

Seeded From UniProt

complete

enables

GO:0005247

voltage-gated chloride channel activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000189250
RGD:2362
RGD:621219
SGD:S000003801

F

Seeded From UniProt

complete

part_of

GO:0000324

fungal-type vacuole

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000914046
SGD:S000003801

C

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005247

P

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005247

P

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005247

P

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005254

P

Seeded From UniProt

complete

involved_in

GO:1902600

proton transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015299

P

Seeded From UniProt

complete

enables

GO:0005247

voltage-gated chloride channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001807

F

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001807

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001807

P

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0005254

chloride channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

P

Seeded From UniProt

complete

part_of

GO:0034707

chloride channel complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

part_of

GO:0031902

late endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0224

C

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0100

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Gaxiola, RA et al. (1998) The yeast CLC chloride channel functions in cation homeostasis. Proc. Natl. Acad. Sci. U.S.A. 95 4046-50 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Schwappach, B et al. (1998) Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p. J. Biol. Chem. 273 15110-8 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 López-Rodríguez, A et al. (2007) The product of the gene GEF1 of Saccharomyces cerevisiae transports Cl- across the plasma membrane. FEMS Yeast Res. 7 1218-29 PubMed GONUTS page
  4. ↑ 4.0 4.1 Wächter, A & Schwappach, B (2005) The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop. FEBS Lett. 579 1149-53 PubMed GONUTS page
  5. ↑ Flis, K et al. (2002) The Gef1 protein of Saccharomyces cerevisiae is associated with chloride channel activity. Biochem. Biophys. Res. Commun. 294 1144-50 PubMed GONUTS page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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