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PMID:9520490
| Citation |
Gaxiola, RA, Yuan, DS, Klausner, RD and Fink, GR (1998) The yeast CLC chloride channel functions in cation homeostasis. Proc. Natl. Acad. Sci. U.S.A. 95:4046-50 |
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| Abstract |
A defect in the yeast GEF1 gene, a CLC chloride channel homolog leads to an iron requirement and cation sensitivity. The iron requirement is due to a failure to load Cu2+ onto a component of the iron uptake system, Fet3. This process, which requires both Gef1 and the Menkes disease Cu2+-ATPase yeast homolog Ccc2, occurs in late- or post-Golgi vesicles, where Gef1 and Ccc2 are localized. The defects of gef1 mutants can be suppressed by the introduction of Torpedo marmorata CLC-0 or Arabidopsis thaliana CLC-c and -d chloride channel genes. The functions of Gef1 in cation homeostasis provide clues to the understanding of diseases caused by chloride channel mutations in humans and cation toxicity in plants. |
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| Keywords |
Cations/metabolism; Chloride Channels/genetics; Chloride Channels/metabolism; Humans; Ion Transport; Iron/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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