YEAST:GAL80

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	GAL80
Protein Name(s)	Galactose/lactose metabolism regulatory protein GAL80
External Links
UniProt	P04387
EMBL	X01667 Z46729 Z47816 BK006946
PIR	A03606
RefSeq	NP_013661.1
PDB	3BTS 3BTU 3BTV 3V2U
PDBsum	3BTS 3BTU 3BTV 3V2U
ProteinModelPortal	P04387
SMR	P04387
BioGrid	35117
DIP	DIP-594N
IntAct	P04387
MINT	MINT-2786797
STRING	4932.YML051W
MaxQB	P04387
PaxDb	P04387
EnsemblFungi	[example_ID YML051W]
GeneID	854954
KEGG	sce:YML051W
CYGD	YML051w
SGD	S000004515
eggNOG	COG0673
HOGENOM	HOG000000744
InParanoid	P04387
OMA	APIRICI
OrthoDB	EOG7GTTGR
BioCyc	YEAST:G3O-32648-MONOMER
EvolutionaryTrace	P04387
NextBio	978027
Proteomes	UP000002311
Genevestigator	P04387
GO	GO:0005737 GO:0005634 GO:0003677 GO:0019210 GO:0016491 GO:0001102 GO:0006012 GO:0033673 GO:0043433 GO:0000122 GO:0006351
Gene3D	3.40.50.720
InterPro	IPR016040 IPR000683
Pfam	PF01408

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:9811836^[1]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000006169	P	Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:9811836^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	PMID:18957435^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019210	kinase inhibitor activity	PMID:18957435^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006012	galactose metabolic process	PMID:6092916^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10866670^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18952899^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10866670^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18952899^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:9811836^[1]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000006169	F	Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	PMID:9811836^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:6092916^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23858060^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04387	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18467557^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04387	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016491	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000683	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0006012	galactose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0299	P	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ansari, AZ et al. (1998) A transcriptional activating region with two contrasting modes of protein interaction. Proc. Natl. Acad. Sci. U.S.A. 95 13543-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Sellick, CA et al. (2009) The effect of ligand binding on the galactokinase activity of yeast Gal1p and its ability to activate transcription. J. Biol. Chem. 284 229-36 PubMed GONUTS page
↑ ^3.0 ^3.1 Torchia, TE et al. (1984) Disruption of regulatory gene GAL80 in Saccharomyces cerevisiae: effects on carbon-controlled regulation of the galactose/melibiose pathway genes. Mol. Cell. Biol. 4 1521-7 PubMed GONUTS page
↑ ^4.0 ^4.1 Peng, G & Hopper, JE (2000) Evidence for Gal3p's cytoplasmic location and Gal80p's dual cytoplasmic-nuclear location implicates new mechanisms for controlling Gal4p activity in Saccharomyces cerevisiae. Mol. Cell. Biol. 20 5140-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Wightman, R et al. (2008) Localization and interaction of the proteins constituting the GAL genetic switch in Saccharomyces cerevisiae. Eukaryotic Cell 7 2061-8 PubMed GONUTS page
↑ Egriboz, O et al. (2013) Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch. Mol. Cell. Biol. 33 3667-74 PubMed GONUTS page
↑ Tarassov, K et al. (2008) An in vivo map of the yeast protein interactome. Science 320 1465-70 PubMed GONUTS page

[PMID:9811836-1] 1.0 ^1.1 ^1.2 ^1.3 Ansari, AZ et al. (1998) A transcriptional activating region with two contrasting modes of protein interaction. Proc. Natl. Acad. Sci. U.S.A. 95 13543-8 PubMed GONUTS page

[PMID:18957435-2] 2.0 ^2.1 Sellick, CA et al. (2009) The effect of ligand binding on the galactokinase activity of yeast Gal1p and its ability to activate transcription. J. Biol. Chem. 284 229-36 PubMed GONUTS page

[PMID:6092916-3] 3.0 ^3.1 Torchia, TE et al. (1984) Disruption of regulatory gene GAL80 in Saccharomyces cerevisiae: effects on carbon-controlled regulation of the galactose/melibiose pathway genes. Mol. Cell. Biol. 4 1521-7 PubMed GONUTS page

[PMID:10866670-4] 4.0 ^4.1 Peng, G & Hopper, JE (2000) Evidence for Gal3p's cytoplasmic location and Gal80p's dual cytoplasmic-nuclear location implicates new mechanisms for controlling Gal4p activity in Saccharomyces cerevisiae. Mol. Cell. Biol. 20 5140-8 PubMed GONUTS page

[PMID:18952899-5] 5.0 ^5.1 Wightman, R et al. (2008) Localization and interaction of the proteins constituting the GAL genetic switch in Saccharomyces cerevisiae. Eukaryotic Cell 7 2061-8 PubMed GONUTS page

[PMID:23858060-6] Egriboz, O et al. (2013) Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch. Mol. Cell. Biol. 33 3667-74 PubMed GONUTS page

[PMID:18467557-7] Tarassov, K et al. (2008) An in vivo map of the yeast protein interactome. Science 320 1465-70 PubMed GONUTS page

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YEAST:GAL80

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