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YEAST:ERG1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) ERG1
Protein Name(s) Squalene monooxygenase

Squalene epoxidase (ECO:0000303 with PMID:8358382[1]) SE

External Links
UniProt P32476
EMBL M64994
Z72960
BK006941
PIR S64489
RefSeq NP_011691.1
ProteinModelPortal P32476
BioGrid 33428
DIP DIP-6325N
IntAct P32476
MINT MINT-1324933
ChEMBL CHEMBL1888
MaxQB P32476
PRIDE P32476
TopDownProteomics P32476
EnsemblFungi YGR175C
GeneID 853086
KEGG sce:YGR175C
EuPathDB FungiDB:YGR175C
SGD S000003407
GeneTree ENSGT00390000011759
HOGENOM HOG000174713
InParanoid P32476
KO K00511
OMA LQEPDRI
OrthoDB EOG092D1EK2
BioCyc MetaCyc:YGR175C-MONOMER
YEAST:YGR175C-MONOMER
Reactome [www.reactome.org/content/detail/R-SCE-191273 R-SCE-191273]
[www.reactome.org/content/detail/R-SCE-2426168 R-SCE-2426168]
UniPathway UPA00767
PRO PR:P32476
Proteomes UP000002311
GO GO:0005783
GO:0005789
GO:0016021
GO:0005811
GO:0031090
GO:0008144
GO:0050660
GO:0004506
GO:0006696
Gene3D 3.50.50.60
InterPro IPR023753
IPR013698
Pfam PF08491
SUPFAM SSF51905

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004506

squalene monooxygenase activity

PMID:27718188[2]

ECO:0000315

F

Figure 2 in the paper shows the levels of ergosterol and squalene in two types of Saccharomyces cerevisiae. The first is a wild type organism with the gene for erg1^L37P operational. The second is a spontaneous mutant with a change in the erg1^L37P. The figure shows a chromatogram that shows lipid extracts with the levels of ergosterol and squalene shown. It is clear that the wild type shown has a high levels of ergosterol, representing normal function. The wild type shown to the right (with the erg1^L37P mutated) shows low levels of ergosterol and high levels of squalene. Assuming that no other gene was mutated or changed, this shows that squalene is an intermediate in the production of ergosterol.

complete
CACAO 12297

part_of

GO:0005783

endoplasmic reticulum

PMID:26928762[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:14638499[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006696

ergosterol biosynthetic process

PMID:200835[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005811

lipid droplet

PMID:24868093[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005811

lipid droplet

PMID:9450962[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:9450962[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004506

squalene monooxygenase activity

PMID:200835[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004506

squalene monooxygenase activity

PMID:9450962[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016126

sterol biosynthetic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000089417
TAIR:locus:2037660

P

Seeded From UniProt

complete

involved_in

GO:0006696

ergosterol biosynthetic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000851137
SGD:S000003407

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000089417
SGD:S000003407

C

Seeded From UniProt

complete

enables

GO:0004506

squalene monooxygenase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000089417
RGD:3755
SGD:S000003407
TAIR:locus:2037660
TAIR:locus:2137569

F

Seeded From UniProt

complete

enables

GO:0004506

squalene monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013698
InterPro:IPR040125

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013698

C

Seeded From UniProt

complete

involved_in

GO:0016126

sterol biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040125

P

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013698

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013698

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0492

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

part_of

GO:0031090

organelle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0165

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Satoh, T et al. (1993) Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae. Biol. Pharm. Bull. 16 349-52 PubMed GONUTS page
  2. ↑ Valachovič, M & Hapala, I (2017) Biosynthetic Approaches to Squalene Production: The Case of Yeast. Methods Mol. Biol. 1494 95-106 PubMed GONUTS page
  3. ↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
  4. ↑ Leber, R et al. (2003) Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 47 3890-900 PubMed GONUTS page
  5. ↑ 5.0 5.1 Karst, F & Lacroute, F (1977) Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. Mol. Gen. Genet. 154 269-77 PubMed GONUTS page
  6. ↑ Currie, E et al. (2014) High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J. Lipid Res. 55 1465-1477 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Leber, R et al. (1998) Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles. Mol. Biol. Cell 9 375-86 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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