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YEAST:DOT1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) DOT1 (synonyms: KMT4, PCH1)
Protein Name(s) Histone-lysine N-methyltransferase, H3 lysine-79 specific

Disrupter of telomere silencing protein 1 Histone H3-K79 methyltransferase H3-K79-HMTase Lysine N-methyltransferase 4

External Links
UniProt Q04089
EMBL U33007
BK006938
PIR S69720
RefSeq NP_010728.1
PDB 1M0R
1U2Z
PDBsum 1M0R
1U2Z
ProteinModelPortal Q04089
SMR Q04089
BioGrid 32496
DIP DIP-2560N
IntAct Q04089
MINT MINT-426373
iPTMnet Q04089
MaxQB Q04089
EnsemblFungi [example_ID YDR440W]
GeneID 852050
KEGG sce:YDR440W
EuPathDB FungiDB:YDR440W
SGD S000002848
GeneTree ENSGT00390000013515
HOGENOM HOG000112251
InParanoid Q04089
KO K11427
OMA YTRSIHP
OrthoDB EOG7KH9VN
BioCyc YEAST:G3O-29974-MONOMER
Reactome R-SCE-3214841
EvolutionaryTrace Q04089
NextBio 970311
PRO PR:Q04089
Proteomes UP000002311
GO GO:0000781
GO:0005634
GO:0003677
GO:0031151
GO:0031493
GO:0006348
GO:0000077
GO:0044783
GO:0070911
GO:0034729
GO:0031573
GO:0051598
GO:0006289
GO:0006301
GO:0000725
GO:0006351
Gene3D 3.40.50.150
InterPro IPR021162
IPR025789
IPR030445
IPR029063
PANTHER PTHR21451
Pfam PF08123
PIRSF PIRSF017570
SUPFAM SSF53335
PROSITE PS51569

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043486

histone exchange

PMID:29339748[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006334

nucleosome assembly

PMID:29339748[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0099114

chromatin silencing at subtelomere

PMID:26587833[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031452

negative regulation of heterochromatin assembly

PMID:26587833[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070911

global genome nucleotide-excision repair

PMID:21460225[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051598

meiotic recombination checkpoint

PMID:11029058[4]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000000981
SGD:S000002693

P

Seeded From UniProt

complete

involved_in

GO:0044783

G1 DNA damage checkpoint

PMID:16166626[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034729

histone H3-K79 methylation

PMID:12080090[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034729

histone H3-K79 methylation

PMID:12080090[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031573

intra-S DNA damage checkpoint

PMID:16166626[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031493

nucleosomal histone binding

PMID:18158898[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031151

histone methyltransferase activity (H3-K79 specific)

PMID:12080090[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031151

histone methyltransferase activity (H3-K79 specific)

PMID:12080090[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031151

histone methyltransferase activity (H3-K79 specific)

PMID:18158898[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006348

chromatin silencing at telomere

PMID:11029058[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006301

postreplication repair

PMID:17267293[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000000662
SGD:S000003026

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

PMID:17267293[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000005943

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

PMID:17267293[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11029058[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:17267293[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004494

P

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:17267293[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

PMID:17267293[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000002625

P

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

PMID:17267293[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000677

regulation of transcription regulatory region DNA binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000485246
UniProtKB:Q8TEK3

P

Seeded From UniProt

complete

enables

GO:0031151

histone methyltransferase activity (H3-K79 specific)

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264495
PANTHER:PTN000485246
SGD:S000002848

F

Seeded From UniProt

complete

involved_in

GO:0006348

chromatin silencing at telomere

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264495
PANTHER:PTN000485246
SGD:S000002848

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264495
PANTHER:PTN000485246
SGD:S000002848
UniProtKB:Q8TEK3

C

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000485246
SGD:S000002848

P

Seeded From UniProt

complete

involved_in

GO:0034729

histone H3-K79 methylation

PMID:15851025[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0006348

C

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0006348

C

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0006348

C

Seeded From UniProt

complete

part_of

GO:0099115

chromosome, subtelomeric region

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0099114

C

Seeded From UniProt

complete

involved_in

GO:0000077

DNA damage checkpoint

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021162

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021162

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021162

P

Seeded From UniProt

complete

involved_in

GO:0006348

chromatin silencing at telomere

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021162

P

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021162
InterPro:IPR025789

F

Seeded From UniProt

complete

enables

GO:0031151

histone methyltransferase activity (H3-K79 specific)

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030445

F

Seeded From UniProt

complete

enables

GO:0031493

nucleosomal histone binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021162

F

Seeded From UniProt

complete

involved_in

GO:0034729

histone H3-K79 methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021162
InterPro:IPR030445

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030445

P

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.43

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Lee, S et al. (2018) Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast. Nat Commun 9 240 PubMed GONUTS page
  2. ↑ 2.0 2.1 Larin, ML et al. (2015) Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin. PLoS Genet. 11 e1005425 PubMed GONUTS page
  3. ↑ Tatum, D & Li, S (2011) Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79. J. Biol. Chem. 286 17530-5 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 San-Segundo, PA & Roeder, GS (2000) Role for the silencing protein Dot1 in meiotic checkpoint control. Mol. Biol. Cell 11 3601-15 PubMed GONUTS page
  5. ↑ 5.0 5.1 Wysocki, R et al. (2005) Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol. Cell. Biol. 25 8430-43 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Ng, HH et al. (2002) Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev. 16 1518-27 PubMed GONUTS page
  7. ↑ 7.0 7.1 Altaf, M et al. (2007) Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol. Cell 28 1002-14 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Bostelman, LJ et al. (2007) Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae. DNA Repair (Amst.) 6 383-95 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. ↑ Okada, Y et al. (2005) hDOT1L links histone methylation to leukemogenesis. Cell 121 167-78 PubMed GONUTS page
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