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YEAST:DAM1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) DAM1
Protein Name(s) DASH complex subunit DAM1

DUO1 and MPS1-interacting protein 1 Kinetochore assembly protein DAM1 Outer kinetochore protein DAM1

External Links
UniProt P53267
EMBL AF280542
Z72898
BK006941
PIR S64421
RefSeq NP_011628.4
ProteinModelPortal P53267
BioGrid 33360
DIP DIP-1286N
IntAct P53267
MINT MINT-405702
iPTMnet P53267
MaxQB P53267
PRIDE P53267
EnsemblFungi YGR113W
GeneID 853010
KEGG sce:YGR113W
EuPathDB FungiDB:YGR113W
SGD S000003345
HOGENOM HOG000000932
InParanoid P53267
KO K02307
OMA LLYGLMC
OrthoDB EOG092C5P0B
BioCyc YEAST:G3O-30822-MONOMER
PRO PR:P53267
Proteomes UP000002311
GO GO:0005737
GO:0042729
GO:1990537
GO:0044732
GO:0042802
GO:0008608
GO:0051301
GO:1990758
GO:0051987
GO:0031116
InterPro IPR013962
Pfam PF08653
ProDom PD398536

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045926

negative regulation of growth

PMID:23418575[1]

ECO:0000315

P

As noted in the paper, when Dam1 is hyperphosphorylated, there is a cell growth can be negatively regulated. See figure 6. Uniprot Nomenclature: DASH complex subunit DAM1 Uniprot ID: P53267 Organism: Saccharomyces cerevisiae

complete
CACAO 12724

involved_in

GO:0051987

positive regulation of attachment of spindle microtubules to kinetochore

PMID:20479465[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051987

positive regulation of attachment of spindle microtubules to kinetochore

PMID:20479468[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0051010

microtubule plus-end binding

PMID:17620411[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

contributes_to

GO:0051010

microtubule plus-end binding

PMID:20479465[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0042729

DASH complex

PMID:15664196[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0042729

DASH complex

PMID:15640796[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031116

positive regulation of microtubule polymerization

PMID:15664196[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008608

attachment of spindle microtubules to kinetochore

PMID:17620411[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0008017

microtubule binding

PMID:16777964[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

contributes_to

GO:0008017

microtubule binding

PMID:15664196[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1990758

mitotic sister chromatid biorientation

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001999359
PomBase:SPAC589.08c

P

Seeded From UniProt

complete

part_of

GO:1990537

mitotic spindle polar microtubule

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001999359
PomBase:SPAC589.08c

C

Seeded From UniProt

complete

enables

GO:0051010

microtubule plus-end binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001999359
SGD:S000003345

F

Seeded From UniProt

complete

part_of

GO:0044732

mitotic spindle pole body

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001999359
PomBase:SPAC589.08c

C

Seeded From UniProt

complete

part_of

GO:0042729

DASH complex

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000195338
PANTHER:PTN001999359
PomBase:SPAC589.08c
SGD:S000003345

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:12925767[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53267

F

occurs_in:(GO:0000776)

Seeded From UniProt

complete

involved_in

GO:0008608

attachment of spindle microtubules to kinetochore

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013962

P

Seeded From UniProt

complete

part_of

GO:0042729

DASH complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013962

C

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013962

C

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0159

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Böhm, S & Buchberger, A (2013) The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). PLoS ONE 8 e56486 PubMed GONUTS page
  2. ↑ 2.0 2.1 Lampert, F et al. (2010) The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex. J. Cell Biol. 189 641-9 PubMed GONUTS page
  3. ↑ Tien, JF et al. (2010) Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B. J. Cell Biol. 189 713-23 PubMed GONUTS page
  4. ↑ 4.0 4.1 Tanaka, K et al. (2007) Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles. J. Cell Biol. 178 269-81 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Westermann, S et al. (2005) Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol. Cell 17 277-90 PubMed GONUTS page
  6. ↑ Miranda, JJ et al. (2005) The yeast DASH complex forms closed rings on microtubules. Nat. Struct. Mol. Biol. 12 138-43 PubMed GONUTS page
  7. ↑ Asbury, CL et al. (2006) The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement. Proc. Natl. Acad. Sci. U.S.A. 103 9873-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ Shang, C et al. (2003) Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p. Mol. Biol. Cell 14 3342-55 PubMed GONUTS page
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