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YEAST:CHS2

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) CHS2
Protein Name(s) Chitin synthase 2

Chitin-UDP acetyl-glucosaminyl transferase 2

External Links
UniProt P14180
EMBL M23865
Z35907
BK006936
PIR S45167
RefSeq NP_009594.1
ProteinModelPortal P14180
BioGrid 32739
DIP DIP-3819N
IntAct P14180
MINT MINT-532106
STRING 4932.YBR038W
CAZy GT2
MaxQB P14180
PaxDb P14180
PRIDE P14180
EnsemblFungi [example_ID YBR038W]
GeneID 852326
KEGG sce:YBR038W
CYGD YBR038w
SGD S000000242
eggNOG COG1215
GeneTree ENSGT00730000113171
HOGENOM HOG000162144
InParanoid P14180
KO K00698
OMA ANSESKR
OrthoDB EOG7W6WV3
BioCyc MetaCyc:MONOMER-17132
YEAST:YBR038W-MONOMER
NextBio 971032
Proteomes UP000002311
Genevestigator P14180
GO GO:0005935
GO:0016021
GO:0004100
GO:0000916
GO:0071555
GO:0006031
InterPro IPR004835
IPR004834
IPR013616
IPR029044
PANTHER PTHR22914
Pfam PF01644
PF08407
ProDom PD002998
SUPFAM SSF53448

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005935

cellular bud neck

PMID:2968606[1]

ECO:0000315

C

Figure 4. Cells that contained a disrupted chs2 gene did not form a septum.

complete
CACAO 8840

part_of

GO:0005935

cellular bud neck

PMID:15772160[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000090)

Seeded From UniProt

complete

involved_in

GO:1902406

mitotic actomyosin contractile ring maintenance

PMID:15772160[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:1902404)

Seeded From UniProt

complete

involved_in

GO:0006031

chitin biosynthetic process

PMID:22573892[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005935

cellular bud neck

PMID:8909536[4]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000093)

Seeded From UniProt

complete

enables

GO:0004100

chitin synthase activity

PMID:9990311[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030428

cell septum

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001115588
UniProtKB:A0A1D8PJ29
UniProtKB:A0A1D8PTV3
UniProtKB:C8V173
UniProtKB:G5EB74
UniProtKB:P30583
UniProtKB:Q00757
UniProtKB:Q5A594

C

Seeded From UniProt

complete

enables

GO:0004100

chitin synthase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001115588
PomBase:SPAC13G6.12c
PomBase:SPBC1709.01
SGD:S000000227
SGD:S000000242
SGD:S000005136
UniProtKB:A0A1D8PJ29
UniProtKB:A0A1D8PTV3
UniProtKB:G5EB74
UniProtKB:P78611
UniProtKB:Q00757

F

Seeded From UniProt

complete

involved_in

GO:0000918

division septum site selection

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001487375
UniProtKB:P30584

P

Seeded From UniProt

complete

enables

GO:0004100

chitin synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004834
InterPro:IPR013616

F

Seeded From UniProt

complete

involved_in

GO:0006031

chitin biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004834

P

Seeded From UniProt

complete

enables

GO:0016758

transferase activity, transferring hexosyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004835

F

Seeded From UniProt

complete

enables

GO:0004100

chitin synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.16

F

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Silverman, SJ et al. (1988) Chitin synthase 2 is essential for septum formation and cell division in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 85 4735-9 PubMed GONUTS page
  2. 2.0 2.1 VerPlank, L & Li, R (2005) Cell cycle-regulated trafficking of Chs2 controls actomyosin ring stability during cytokinesis. Mol. Biol. Cell 16 2529-43 PubMed GONUTS page
  3. Oh, Y et al. (2012) Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Mol. Biol. Cell 23 2445-56 PubMed GONUTS page
  4. Chuang, JS & Schekman, RW (1996) Differential trafficking and timed localization of two chitin synthase proteins, Chs2p and Chs3p. J. Cell Biol. 135 597-610 PubMed GONUTS page
  5. Yabe, T et al. (1998) Mutational analysis of chitin synthase 2 of Saccharomyces cerevisiae. Identification of additional amino acid residues involved in its catalytic activity. Eur. J. Biochem. 258 941-7 PubMed GONUTS page
  6. 6.0 6.1 6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page