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YEAST:BDF1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) BDF1
Protein Name(s) Bromodomain-containing factor 1
External Links
UniProt P35817
EMBL Z18944
U18116
U19729
L13469
BK006945
PIR S55955
RefSeq NP_013503.1
ProteinModelPortal P35817
SMR P35817
BioGrid 31658
DIP DIP-1624N
IntAct P35817
MINT MINT-407031
STRING 4932.YLR399C
MaxQB P35817
PaxDb P35817
PeptideAtlas P35817
PRIDE P35817
EnsemblFungi [example_ID YLR399C]
GeneID 851115
KEGG sce:YLR399C
CYGD YLR399c
SGD S000004391
eggNOG COG5076
GeneTree ENSGT00760000119206
HOGENOM HOG000248774
InParanoid P35817
KO K11684
OMA VEMPRSA
OrthoDB EOG7Z69S1
BioCyc YEAST:G3O-32463-MONOMER
NextBio 967833
PRO PR:P35817
Proteomes UP000002311
Genevestigator P35817
GO GO:0000790
GO:0000812
GO:0003682
GO:0001047
GO:0070577
GO:0001094
GO:0006338
GO:0006281
GO:0031452
GO:1900051
GO:0090054
GO:0031938
GO:0034401
GO:0009301
GO:0030435
Gene3D 1.20.920.10
InterPro IPR001487
IPR018359
IPR027353
Pfam PF00439
PRINTS PR00503
SMART SM00297
SUPFAM SSF47370
PROSITE PS00633
PS50014
PS51525

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1900051

positive regulation of histone exchange

PMID:20332092[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090054

regulation of chromatin silencing at silent mating-type cassette

PMID:12620225[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070577

lysine-acetylated histone binding

PMID:12620224[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070577

lysine-acetylated histone binding

PMID:20126658[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031938

regulation of chromatin silencing at telomere

PMID:12620225[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031452

negative regulation of heterochromatin assembly

PMID:16239142[5]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000002228

P

Seeded From UniProt

complete

involved_in

GO:0031452

negative regulation of heterochromatin assembly

PMID:16239142[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009301

snRNA transcription

PMID:7816623[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006338

chromatin remodeling

PMID:14690608[7]

ECO:0000353

physical interaction evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:7791775[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:12620225[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001094

TFIID-class transcription factor complex binding

PMID:10783167[9]

ECO:0000353

physical interaction evidence used in manual assertion

SGD:S000004840

F

Seeded From UniProt

complete

enables

GO:0001094

TFIID-class transcription factor complex binding

PMID:10783167[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001047

core promoter binding

PMID:12620225[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001047

core promoter binding

PMID:17526728[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000812

Swr1 complex

PMID:19088068[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:7791775[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0030435

sporulation resulting in formation of a cellular spore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0749

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Altaf, M et al. (2010) NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex. J. Biol. Chem. 285 15966-77 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Ladurner, AG et al. (2003) Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries. Mol. Cell 11 365-76 PubMed GONUTS page
  3. Matangkasombut, O & Buratowski, S (2003) Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation. Mol. Cell 11 353-63 PubMed GONUTS page
  4. Zhang, Q et al. (2010) Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PLoS ONE 5 e8903 PubMed GONUTS page
  5. 5.0 5.1 Raisner, RM et al. (2005) Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell 123 233-48 PubMed GONUTS page
  6. Lygerou, Z et al. (1994) The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs. Nucleic Acids Res. 22 5332-40 PubMed GONUTS page
  7. Krogan, NJ et al. (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol. Cell 12 1565-76 PubMed GONUTS page
  8. 8.0 8.1 Chua, P & Roeder, GS (1995) Bdf1, a yeast chromosomal protein required for sporulation. Mol. Cell. Biol. 15 3685-96 PubMed GONUTS page
  9. 9.0 9.1 Matangkasombut, O et al. (2000) Bromodomain factor 1 corresponds to a missing piece of yeast TFIID. Genes Dev. 14 951-62 PubMed GONUTS page
  10. Durant, M & Pugh, BF (2007) NuA4-directed chromatin transactions throughout the Saccharomyces cerevisiae genome. Mol. Cell. Biol. 27 5327-35 PubMed GONUTS page
  11. Wu, WH et al. (2009) N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex. J. Biol. Chem. 284 6200-7 PubMed GONUTS page