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YEAST:ATG18

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) ATG18 (ECO:0000303 with PMID:14536056[1])
Protein Name(s) Autophagy-related protein 18 (ECO:0000303 with PMID:14536056[1])

Cytoplasm to vacuole targeting protein 18 (ECO:0000303 with PMID:11739783[2]) Needed for premeiotic replication protein 1 (ECO:0000303 with PMID:11470404[3]) Swollen vacuole phenotype protein 1 (ECO:0000303 with PMID:15103325[4])

External Links
UniProt P43601
EMBL D50617
BK006940
PIR S56276
RefSeq NP_444297.1
ProteinModelPortal P43601
SMR P43601
BioGrid 31174
DIP DIP-5185N
IntAct P43601
MINT MINT-541235
STRING 4932.YFR021W
TCDB 9.A.15.1.1
MaxQB P43601
PaxDb P43601
EnsemblFungi [example_ID YFR021W]
GeneID 850577
KEGG sce:YFR021W
CYGD YFR021w
SGD S000001917
eggNOG NOG317564
GeneTree ENSGT00730000110845
HOGENOM HOG000217543
InParanoid P43601
KO K17908
OMA HATTNNI
OrthoDB EOG7BW0V3
BioCyc YEAST:G3O-30472-MONOMER
Reactome REACT_188969
NextBio 966400
Proteomes UP000002311
Genevestigator P43601
GO GO:0005829
GO:0005768
GO:0010008
GO:0000329
GO:0070772
GO:0000407
GO:0034045
GO:0005774
GO:0080025
GO:0043130
GO:0032258
GO:0045324
GO:0044805
GO:0016236
GO:0030242
GO:0034727
GO:0006624
Gene3D 2.130.10.10
InterPro IPR015943
IPR001680
IPR017986
Pfam PF00400
SMART SM00320
SUPFAM SSF50978
PROSITE PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0000329

fungal-type vacuole membrane

PMID:26928762[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:22842922[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071944

cell periphery

PMID:26928762[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0044090

positive regulation of vacuole organization

PMID:17699591[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0061908

phagophore

PMID:23549786[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0032266

phosphatidylinositol-3-phosphate binding

PMID:15103325[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070273

phosphatidylinositol-4-phosphate binding

PMID:15155809[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0032266

phosphatidylinositol-3-phosphate binding

PMID:15155809[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0080025

phosphatidylinositol-3,5-bisphosphate binding

PMID:15103325[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070772

PAS complex

PMID:19037259[10]

ECO:0000353

physical interaction evidence used in manual assertion

SGD:S000004378

C

Seeded From UniProt

complete

part_of

GO:0070772

PAS complex

PMID:19037259[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045324

late endosome to vacuole transport

PMID:15103325[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044805

late nucleophagy

PMID:22768199[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

PMID:21070969[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034727

piecemeal microautophagy of the nucleus

PMID:18701704[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032258

protein localization by the Cvt pathway

PMID:11707261[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032258

protein localization by the Cvt pathway

PMID:16876790[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032258

protein localization by the Cvt pathway

PMID:11707261[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030242

autophagy of peroxisome

PMID:11739783[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:11707261[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:11707261[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006624

vacuolar protein processing

PMID:11707261[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006624

vacuolar protein processing

PMID:11707261[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11707261[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

PMID:18769150[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000407

phagophore assembly site

PMID:18497569[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:15103325[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

PMID:17699591[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0080025

phosphatidylinositol-3,5-bisphosphate binding

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000132136
SGD:S000001917
SGD:S000003455
SGD:S000006021
UniProtKB:Q5MNZ9
UniProtKB:Q9Y4P8
WB:WBGene00012641
WB:WBGene00018294

F

Seeded From UniProt

complete

involved_in

GO:0034497

protein localization to phagophore assembly site

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1923831
PANTHER:PTN000132136
SGD:S000006021

P

Seeded From UniProt

complete

part_of

GO:0034045

phagophore assembly site membrane

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000132136
UniProtKB:Q5MNZ9
UniProtKB:Q9Y4P8

C

Seeded From UniProt

complete

enables

GO:0032266

phosphatidylinositol-3-phosphate binding

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1923831
PANTHER:PTN000132136
SGD:S000001917
SGD:S000003455
SGD:S000006021
UniProtKB:Q5MNZ9
UniProtKB:Q9Y4P8
WB:WBGene00012641
WB:WBGene00018294

F

Seeded From UniProt

complete

part_of

GO:0019898

extrinsic component of membrane

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000132136
SGD:S000003455

C

Seeded From UniProt

complete

involved_in

GO:0006497

protein lipidation

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000132136
SGD:S000006021

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000132136
SGD:S000001917
SGD:S000006021
UniProtKB:Q93VB2
UniProtKB:Q9Y4P8

C

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000132136
SGD:S000006021

P

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000881190
PomBase:SPAC589.07c
SGD:S000001917
SGD:S000006021

C

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:21873635[18]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035850
PANTHER:PTN000132136
UniProtKB:Q9Y4P8
WB:WBGene00012641

P

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

part_of

GO:0005773

vacuole

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0926

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0100

C

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

complete

part_of

GO:0034045

phagophore assembly site membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0221

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Klionsky, DJ et al. (2003) A unified nomenclature for yeast autophagy-related genes. Dev. Cell 5 539-45 PubMed GONUTS page
  2. ↑ 2.0 2.1 Guan, J et al. (2001) Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol. Biol. Cell 12 3821-38 PubMed GONUTS page
  3. ↑ Rabitsch, KP et al. (2001) A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr. Biol. 11 1001-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Dove, SK et al. (2004) Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J. 23 1922-33 PubMed GONUTS page
  5. ↑ 5.0 5.1 Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
  6. ↑ Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page
  7. ↑ 7.0 7.1 Efe, JA et al. (2007) Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol. Biol. Cell 18 4232-44 PubMed GONUTS page
  8. ↑ Suzuki, K et al. (2013) Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. J. Cell. Sci. 126 2534-44 PubMed GONUTS page
  9. ↑ 9.0 9.1 Strømhaug, PE et al. (2004) Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol. Biol. Cell 15 3553-66 PubMed GONUTS page
  10. ↑ 10.0 10.1 Jin, N et al. (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 27 3221-34 PubMed GONUTS page
  11. ↑ Mijaljica, D et al. (2012) A late form of nucleophagy in Saccharomyces cerevisiae. PLoS ONE 7 e40013 PubMed GONUTS page
  12. ↑ Pashkova, N et al. (2010) WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol. Cell 40 433-43 PubMed GONUTS page
  13. ↑ Krick, R et al. (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol. Biol. Cell 19 4492-505 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 Barth, H et al. (2001) Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p. FEBS Lett. 508 23-8 PubMed GONUTS page
  15. ↑ Krick, R et al. (2006) The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy. FEBS Lett. 580 4632-8 PubMed GONUTS page
  16. ↑ Krick, R et al. (2008) Dissecting the localization and function of Atg18, Atg21 and Ygr223c. Autophagy 4 896-910 PubMed GONUTS page
  17. ↑ Ma, J et al. (2008) Localization of autophagy-related proteins in yeast using a versatile plasmid-based resource of fluorescent protein fusions. Autophagy 4 792-800 PubMed GONUTS page
  18. ↑ 18.0 18.1 18.2 18.3 18.4 18.5 18.6 18.7 18.8 18.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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