YEAST:2AAA

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	TPD3
Protein Name(s)	Protein phosphatase PP2A regulatory subunit A PR65
External Links
UniProt	P31383
EMBL	M98389 L05146 BK006935
PIR	S36718
RefSeq	NP_009386.1
ProteinModelPortal	P31383
SMR	P31383
BioGrid	31750
DIP	DIP-2010N
IntAct	P31383
MINT	MINT-402163
STRING	4932.YAL016W
MaxQB	P31383
PaxDb	P31383
PeptideAtlas	P31383
EnsemblFungi	[example_ID YAL016W]
GeneID	851217
KEGG	sce:YAL016W
SGD	S000000014
eggNOG	NOG247268
GeneTree	ENSGT00730000110944
HOGENOM	HOG000078539
InParanoid	P31383
KO	K03456
OMA	YMENNEN
OrthoDB	EOG7GJ6NN
BioCyc	YEAST:G3O-28828-MONOMER
Reactome	REACT_229625 REACT_230393 REACT_231087 REACT_241060 REACT_261338
NextBio	968106
Proteomes	UP000002311
Genevestigator	P31383
GO	GO:0005935 GO:0005934 GO:0005737 GO:0043332 GO:0005634 GO:0000159 GO:0005816 GO:0016311 GO:0007094 GO:0006417
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR000357 IPR021133
Pfam	PF02985
SUPFAM	SSF48371
PROSITE	PS50077

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006970	response to osmotic stress	PMID:18162590^[1]	ECO:0000316		UniProtKB:Q38845	P		Fig.1D	complete
	GO:0045927	positive regulation of growth	PMID:18162590^[1]	ECO:0000316		UniProtKB:Q38845	P		Fig.1A,D .... rescued growth of tpd3 mutant…..	complete
part_of	GO:0043332	mating projection tip	PMID:12388751^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0000159	protein phosphatase type 2A complex	PMID:17550305^[3]	ECO:0000314			C			complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	PMID:9001215^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	PMID:10329624^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005935	cellular bud neck	PMID:12388751^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005934	cellular bud tip	PMID:12388751^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005816	spindle pole body	PMID:12388751^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12388751^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12388751^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0004722	protein serine/threonine phosphatase activity	PMID:17550305^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0004722	protein serine/threonine phosphatase activity	PMID:17550305^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q12461) has_direct_input:(UniProtKB:P23594)	Seeded From UniProt	complete
part_of	GO:0000159	protein phosphatase type 2A complex	PMID:17550305^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000159	protein phosphatase type 2A complex	PMID:8600023^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019888	protein phosphatase regulator activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000068596 TAIR:locus:2031165	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000068663 SGD:S000000014 UniProtKB:Q32PI5	C		Seeded From UniProt	complete
contributes_to	GO:0004722	protein serine/threonine phosphatase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926334 PANTHER:PTN000068596 SGD:S000000014 UniProtKB:Q5ADN1 dictyBase:DDB_G0283601	F		Seeded From UniProt	complete
part_of	GO:0000159	protein phosphatase type 2A complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1926334 PANTHER:PTN000068663 SGD:S000000014 UniProtKB:P30153 WB:WBGene00003901 dictyBase:DDB_G0283601	C		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004722	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004722	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004722	P		Seeded From UniProt	complete
involved_in	GO:0043666	regulation of phosphoprotein phosphatase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019888	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Blakeslee, JJ et al. (2008) Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem organization and stress response in roots. Plant Physiol. 146 539-53 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gentry, MS & Hallberg, RL (2002) Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol. Biol. Cell 13 3477-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hombauer, H et al. (2007) Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol. 5 e155 PubMed GONUTS page
↑ Wang, Y & Burke, DJ (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol. Cell. Biol. 17 620-6 PubMed GONUTS page
↑ Jiang, Y & Broach, JR (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18 2782-92 PubMed GONUTS page
↑ Nickels, JT & Broach, JR (1996) A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev. 10 382-94 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18162590-1] 1.0 ^1.1 Blakeslee, JJ et al. (2008) Specificity of RCN1-mediated protein phosphatase 2A regulation in meristem organization and stress response in roots. Plant Physiol. 146 539-53 PubMed GONUTS page

[PMID:12388751-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gentry, MS & Hallberg, RL (2002) Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol. Biol. Cell 13 3477-92 PubMed GONUTS page

[PMID:17550305-3] 3.0 ^3.1 ^3.2 ^3.3 Hombauer, H et al. (2007) Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol. 5 e155 PubMed GONUTS page

[PMID:9001215-4] Wang, Y & Burke, DJ (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol. Cell. Biol. 17 620-6 PubMed GONUTS page

[PMID:10329624-5] Jiang, Y & Broach, JR (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18 2782-92 PubMed GONUTS page

[PMID:8600023-6] Nickels, JT & Broach, JR (1996) A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev. 10 382-94 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:2AAA

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