XENLA:PRKDC

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	prkdc
Protein Name(s)	DNA-dependent protein kinase catalytic subunit DNA-PK catalytic subunit DNA-PKcs
External Links
UniProt	Q9DEI1
EMBL	AB016434 AF001413
RefSeq	NP_001079070.1
UniGene	Xl.391
ProteinModelPortal	Q9DEI1
PRIDE	Q9DEI1
GeneID	373602
KEGG	xla:373602
CTD	373602
Xenbase	XB-GENE-866368
HOVERGEN	HBG053681
KO	K06642
GO	GO:0070419 GO:0005730 GO:0005524 GO:0003677 GO:0004677 GO:0006303 GO:0072431
Gene3D	1.10.1070.11 1.25.10.10
InterPro	IPR011989 IPR016024 IPR003152 IPR011009 IPR012582 IPR000403 IPR018936 IPR003151 IPR014009
Pfam	PF02259 PF02260 PF08163 PF00454
SMART	SM01343 SM01344 SM00146
SUPFAM	SSF48371 SSF56112
PROSITE	PS51189 PS51190 PS00915 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:27324260	ECO:0000314			P		In figure E1, a multitude of overhang types were tested with and without the inhibition of DNA-PKcs. In all cases, the inhibition of DNA-PKcs significantly reduced the repair activity of the egg extract as compared to the control.	complete CACAO 12482
	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:27324260	ECO:0000315			P		Figure 2B shows how DNA -PKcs is required for efficient non homologous end repair activity, as evidenced with the assay on repair activity with or without DNA-PKcs inhibitor NU7441. When DNA-PKcs was inhibited, the activity of repair of double stranded breaks via NHEJ was significantly decreased. Xenopus laevis.	complete CACAO 12501
involved_in	GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P78527	P		Seeded From UniProt	complete
part_of	GO:0070419	nonhomologous end joining complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P78527	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004677	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004674	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	F		Seeded From UniProt	complete
enables	GO:0004677	DNA-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582 InterPro:IPR037706	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037706	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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References

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